Validation of the Tenon breast cancer score for predicting non-sentinel lymph node status in breast cancer patients with sentinel lymph node metastasis: a prospective multicenter study

Coutant, Charles; Rouzier, Roman; Fondrinier, É.; Marchal, Frédéric; Guillemin, François; Seince, N; Rodrigues, A.; Daraı̈, Émile; Uzan, Serge; Barranger, Emmanuel

doi:10.1007/s10549-008-9967-7

Cited by 53 publications

(37 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to the authors, the weakness of this scoring system is that it does not take the size of nodal metastasis and extranodal dissemination into account [9]. Studies that validated the Tenon score, reported ROC values of 0.75 [17], 0.82 [24], and 0.582 [12]. The third study, which reported the lowest value, was carried out by Gur et al [12] on a Turkish patient population.…”

Section: Nomogram Resultsmentioning

confidence: 99%

A New and Simple Predictive Formula for Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Positive Sentinel Lymph Nodes, and Validation of 3 Different Nomograms in Turkish Breast Cancer Patients

et al. 2012

View full text Add to dashboard Cite

Background: Nomogram accuracies for predicting non-sentinel lymph node (SLN) involvement vary between different patient populations. Our aim is to put these nomograms to test on our patient population and determine our individual predictive parameters affecting SLN and non-SLN involvement. Patients and Methods: Data from 932 patients was analyzed. Nomogram values were calculated for each patient utilizing MSKCC, Tenon, and MHDF models. Moreover, using our own patient- and tumor-depended parameters, we established a unique predictivity formula for SLN and non-SLN involvement. Results: The calculated area under the curve (AUC) values for MSKCC, Tenon, and MHDF models were 0.727 (95% confidence interval (CI) 0.64–0.8), 0.665 (95% CI 0.59–0.73), and 0.696 (95% CI 0.59–0.79), respectively. Cerb-2 positivity (p = 0.004) and size of the metastasis in the lymph node (p = 0.006) were found to correlate with non-SLN involvement in our study group. The AUC value of the predictivity formula established using these parameters was 0.722 (95% CI 0.63–0.81). Conclusion: The most accurate nomogram for our patient group was the MSKCC nomogram. Our unique predictivity formula proved to be as equally effective and competent as the MSKCC nomogram. However, similar to other nomograms, our predictivity formula requires future validation studies.

show abstract

Section: Nomogram Resultsmentioning

confidence: 99%

A New and Simple Predictive Formula for Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Positive Sentinel Lymph Nodes, and Validation of 3 Different Nomograms in Turkish Breast Cancer Patients

et al. 2012

View full text Add to dashboard Cite

show abstract

“…References validating a nomogram, n= 10 excluded [42][43][44][45][46][47][48][49][50][51] Potentially appropriate references to be included in review, n= 64 …”

Section: Figurementioning

confidence: 99%

Meta-analysis of predictive factors for non-sentinel lymph node metastases in breast cancer patients with a positive SLN

Parra

Peer

Ernst

et al. 2011

European Journal of Surgical Oncology

View full text Add to dashboard Cite

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Methods: A Medline search was conducted that ultimately identified 56 candidate studies. Original data were abstracted from each study and used to calculate odds ratios. The random-effects model was used to combine odds ratios to determine the strength of the associations. associated with the size of metastases, had a correspondingly high odds ratio. Conclusions:We identified 8 factors predictive of NSN metastases that should be recorded and evaluated routinely in SLN databases. These factors should be included in a predictive model that is generally applicable among different populations.van la Parra 3

show abstract

“…D'autres scores ou nomogrammes ont été égale-ment publiés : le score de Tenon [13] d'utilisation simple, récemment évalué dans une série multicentrique confi rmant la reproductibilité du modèle [43] ; le modèle d'utilisation également simple du MD Anderson [108] ; le modèle simple proposé par Chagpar et al [29], avec une population dont le risque d'atteinte des GNS inférieur à 5 % reste très limité, réduisant son intérêt clinique. D'autres scores ont été rapportés, mais n'ont pas été validés de manière prospective.…”

Section: Scores Et Nomogrammesunclassified

Groupe chirurgie

Barranger¹,

Classe²,

Clough³

et al. 2011

Oncologie

Self Cite

View full text Add to dashboard Cite

Groupe de travail : Emmanuel Barranger (chirurgie oncologique), Jean-Marc Classe (chirurgie oncologique), Krishna Clough (chirurgie oncologique), Sylvia Giard (chirurgie oncologique), Gilles Houvenaeghel (chirurgie oncologique), Claude Nos (chirurgie oncologique) Les questions ont été scindées en deux groupes : Problématique liée à la chirurgie du sein ; Problématique liée à la chirurgie du ganglion axillaire sentinelle. Problématique liée à la chirurgie du seinÉtat de l'art des recommandations actuelles sur les marges de sécurité nécessaires lors de l'exérèse conservatrice d'un cancer du sein récidive locale dont la distance en millimètre de la marge n'est qu'un des éléments (niveau de preuve 2, grade B). Cancer du sein multifocal : la question du traitement chirurgical conservateur Veille bibliographique Literature Monitoring tumoraux à plus de 2 cm de la lésion principale dans 43 % des cas [96]. Luttges et al. retrouvent 46 % de tumeurs multifocales et 22 % de tumeurs multicentriques dans leur étude de 1 666 pièces de mastectomie. Tot retrouve 35 % de tumeurs multifocales et 4 % de tumeurs multicentriques dans son étude de 519 pièces [239].Le carcinome lobulaire infi ltrant présente un plus haut risque de multifocalité [60]. Néanmoins, dans la limite d'une résection en marges saines, la chirurgie conservatrice peut lui être appliquée avec la même garantie de contrôle local que pour le carcinome canalaire infi ltrant [195,196,215].

show abstract

Validation of the Tenon breast cancer score for predicting non-sentinel lymph node status in breast cancer patients with sentinel lymph node metastasis: a prospective multicenter study

Cited by 53 publications

References 29 publications

A New and Simple Predictive Formula for Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Positive Sentinel Lymph Nodes, and Validation of 3 Different Nomograms in Turkish Breast Cancer Patients

A New and Simple Predictive Formula for Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Positive Sentinel Lymph Nodes, and Validation of 3 Different Nomograms in Turkish Breast Cancer Patients

Meta-analysis of predictive factors for non-sentinel lymph node metastases in breast cancer patients with a positive SLN

Groupe chirurgie

Contact Info

Product

Resources

About