Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality

Pudjiadi, Antonius Hocky; Pramesti, Dwi Lestari; Pardede, Sudung O.; Djer, Mulyadi M.; Rohsiswatmo, Rinawati; Kaswandani, Nastiti

doi:10.4103/ijciis.ijciis_98_20

Cited by 9 publications

(7 citation statements)

References 21 publications

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“…In a study by Pudjiadi et al, VIS > 11 was a good predictor of mortality in children with septic shock. 24 In a study by Fatimah et al reported that the cut-off value of the ROC curve of VIS concerning mortality was 6 with a sensitivity and specificity of 82.1% and 64.5%, respectively. 25 Previous studies on VIS in children have only associated VIS with cardiac surgery in pediatrics.…”

Section: Dovepressmentioning

confidence: 97%

The Correlations of Human Atrial Natriuretic Peptide on Cardiac Function and Hemodynamics in Pediatric Septic Shock

Setyaningtyas¹,

Soetjipto²,

Endaryanto³

et al. 2022

OAEM

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We aimed to determine the correlations of human Atrial Natriuretic Peptide (ANP) on cardiac function and hemodynamics in pediatric septic shock. Patients and Methods:We conducted an observational and prospective study on 30 children with septic shock. Measurement of the level of human atrial natriuretic peptide was determined in the serum of patients. Cardiac power (CP) is a cardiac function parameter measured with cardiac output (cardiovascular flow) and mean arterial (intravascular) pressure. Cardiac output and mean arterial pressure were monitored using pressure recording analytical methods (PRAM). Hemodynamic status was represented by a vasoactive inotropic score. Results: Thirty pediatric septic shock patients fulfilled the eligibility criteria. The human ANP level was not significantly different in pediatric septic shock on three days of examination. Cardiac power was significantly different in pediatric septic shock on three days of examination. There was a correlation between human ANP and cardiac power on day 3 and human ANP and VIS on day 2. Conclusion: There was a significant correlation between human ANP level and cardiac power on day 3 and ANP level and VIS on day 2. The cardiac power on day 3 and VIS on 48 hours can be alternatives to evaluate the hemodynamic status and cardiac function concerning human ANP in pediatric septic shock.

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Section: Dovepressmentioning

confidence: 97%

The Correlations of Human Atrial Natriuretic Peptide on Cardiac Function and Hemodynamics in Pediatric Septic Shock

Setyaningtyas¹,

Soetjipto²,

Endaryanto³

et al. 2022

OAEM

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“…The VIS is easy to measure, and the results may be calculated instantaneously at the patient’s bedside. Currently, it is used to assess the severity of cardiac malfunction and to estimate the degree of cardiovascular drug support in infants after cardiac surgery [ 13 ]. The cause of CDH-related death is respiratory and circulatory failure [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Preliminary study on the predictive value of the vasoactive-inotropic score for the prognosis of neonatal congenital diaphragmatic hernia

Liu

Wei

et al. 2023

BMC Surg

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Background No study has reported on the relationship between the vasoactive-inotropic score (VIS) and the prognosis of neonates with a severe congenital diaphragmatic hernia (CDH). This study aimed to identify potential risk factors for mortality in patients with CDH. We calculated the VIS based on the vasoactive drugs used during the perioperative period to investigate the relationship between VIS and infant prognosis. Methods We retrospectively analyzed the clinical data of 75 neonates with CDH who were treated at our center between January 2016 and October 2021. We calculated the maximum and mean VIS during the first 24 h of hospitalization (hosVIS [24max] and hosVIS [24mean], respectively) and after surgery (postVIS [24max] and postVIS [24mean], respectively). The relationship between the VIS and the prognosis of neonates with CDH was analyzed using a receiver operating characteristic (ROC) curve, t-test, chi-square test, rank-sum test, and logistic regression analysis. Results In total, 75 participants with CDH were included in the study. The chance of survival was 80%. Our results showed that hosVIS (24max) was an accurate predictor of prognosis (area under the ROC curve = 0.925, p = 0.007). The calculated optimal critical value of hosVIS (24max) for predicting a poor prognosis was 17 (J = 0.75). Multivariate analysis revealed that hosVIS (24max) was an independent risk factor for death in neonates with CDH. Conclusion In neonates with CDH, a higher VIS, especially hosVIS (24max), suggests worsened cardiac function, a more severe condition, and a higher risk of death. The rising VIS score in infants prompts physicians to implement more aggressive treatment to improve cardiovascular function.

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“…Animals could receive inotropic support comprising epinephrine, norepinephrine, milrinone and vasopressin if necessary in order to maintain the mean arterial pressure above 60 mmHg and the cardiac index above 2 L/min per m 2 . The decision to provide inotropic support was based on the animal's vasoactive-inotropic score ( 10 ). Weaning was considered a failure if hemodynamics did not stabilize within 2 h on cardiopulmonary bypass.…”

Section: Methodsmentioning

confidence: 99%

Comparison of “Huaxi-1” or “histidine-tryptophan-ketoglutarate” cardioplegia in an animal model

Yu,

Xiong,

Zhang

et al. 2024

Front. Cardiovasc. Med.

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BackgroundUsing a pig model of cardiopulmonary bypass, we compared outcomes after cardioplegia either with our in-house “Huaxi-1” solution containing natural blood and crystalloid or with the entirely crystalloid, commercially available “histidine-tryptophan-ketoglutarate” solution.MethodsCardiopulmonary bypass was established in 12 healthy male pigs, who were randomized to receive a single dose of either Huaxi-1 or entirely crystalloid. All animals were then subjected to whole-heart ischemia for 90 min, followed by 2 h of reperfusion, after which myocardial injury was assessed in terms of cardiac function, myocardial pathology and levels of biomarkers in plasma, while levels of high-energy phosphate in myocardium were assayed using liquid chromatography.ResultsAnimals given Huaxi-1 cardioplegia required significantly less time to be weaned off bypass, they received significantly lower doses of norepinephrine, and they showed significantly higher levels (mean ± SD) of adenosine triphosphate (14 ± 4 vs. 8 ± 2 µg/mg, P = 0.005), adenosine diphosphate (16 ± 2 vs. 13 ± 2 µg/mg, P = 0.046), and total adenine nucleotide (37 ± 4 vs. 30 ± 3 µg/mg, P = 0.006) in myocardium after 2 h of reperfusion. They also showed less severe bleeding, edema and injury to mitochondria and myofibers in myocardium. The two groups did not differ significantly in doses of inotropic drugs received, cardiac output or levels of biomarkers in plasma.ConclusionsIn this animal model of healthy hearts subjected to 90 min of ischemia, Huaxi-1 cardioplegia may be superior to entirely crystalloid cardioplegia for promoting energy generation and attenuating ischemia/reperfusion injury in myocardium.

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Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality

Cited by 9 publications

References 21 publications

The Correlations of Human Atrial Natriuretic Peptide on Cardiac Function and Hemodynamics in Pediatric Septic Shock

The Correlations of Human Atrial Natriuretic Peptide on Cardiac Function and Hemodynamics in Pediatric Septic Shock

Preliminary study on the predictive value of the vasoactive-inotropic score for the prognosis of neonatal congenital diaphragmatic hernia

Comparison of “Huaxi-1” or “histidine-tryptophan-ketoglutarate” cardioplegia in an animal model

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