Validation of ultratrace analysis of Co, Cr, Mo and Ni in whole blood, serum and urine using ICP-SMS

Krachler, Michael; Heisel, Christian; Kretzer, J. Philippe

doi:10.1039/b821913c

Cited by 38 publications

(25 citation statements)

References 24 publications

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“…The accuracy and validity of this method has previously been demonstrated [18]. To detect not just ions but also particles in the serum, the samples were first digested with high-purity nitric acid (HNO 3 ) and hydrogen peroxide (H 2 O 2 ) in Teflon containers under clean-room conditions in a microwave high-pressure autoclave (ultraCLAVE II Milestone, Bergamo, Italy).…”

Section: Surface Characterisation and Metal Releasementioning

confidence: 99%

Wear in total knee arthroplasty—just a question of polyethylene?

Kretzer

Reinders

Sonntag

et al. 2013

International Orthopaedics (SICOT)

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Purpose Biological reactions against wear particles are a common cause for revision in total knee arthroplasty. To date, wear has mainly been attributed to polyethylene. However, the implants have large metallic surfaces that also could potentially lead to metal wear products (metal ions and debris). The aim of this study was to determine the local release of cobalt, chromium, molybdenum and titanium in total knee arthroplasty during a standard knee wear test. Methods Four moderately conforming fixed-bearing implants were subjected to physiological loadings and motions for 5×10 6 walking cycles in a knee wear simulator. Polyethylene wear was determined gravimetrically and the release of metallic wear products was measured using high resolutioninductively coupled plasma-mass spectrometry. Results A polyethylene wear rate of 7.28±0.27 mg/10 6 cycles was determined and the cumulative mass of released metals measured 1.63±0.28 mg for cobalt, 0.47±0.06 mg for chromium, 0.42±0.06 mg for molybdenum and 1.28±0.14 mg for titanium. Conclusion For other metallic implants such as metal-on-metal total hip arthroplasty, the metal wear products can interact with the immune system, potentially leading to immunotoxic effects. In this study about 12 % by weight of the wear products were metallic, and these particles and ions may become clinically relevant for patients sensitive to these materials in particular. Non-metallic materials (e.g. ceramics or suitable coatings) may be considered for an alternative treatment for those patients.

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Section: Surface Characterisation and Metal Releasementioning

confidence: 99%

Wear in total knee arthroplasty—just a question of polyethylene?

Kretzer

Reinders

Sonntag

et al. 2013

International Orthopaedics (SICOT)

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“…280 Vanadium was quantified in biological fluids by Yang et al 281 At a mass resolution of 4000, the 35 Cl 16 O 1 interference was resolved from the analyte signal. Featherstone and coworkers developed methods for the determination of Se in human plasma using the high-resolution capability of ICP-SFMS, including the identification of some discrepancies in assigned Se levels in Seronorm Trace Elements Serum Level 2.…”

Section: Elemental Analyses Of Body Tissues and Body Fluidsmentioning

confidence: 99%

Inductively Coupled Plasma Mass Spectrometry

Jakubowski

Horsky

Roos

et al. 2014

Sector Field Mass Spectrometry for Elemental and Isotopic Analysis

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ICP-MS is based on the formation of (preferentially monovalent positively) charged atomic ions in an inductively coupled Ar plasma at almost 10 000 K. The ions formed are transferred from the plasma source at ambient pressure into a mass separator operated at high vacuum via a set of cones. The ions are separated according to their mass/charge ratio in the mass separator (quadrupole, magnetic sector field or time-of-flight mass separator). In most cases, the ions are detected using a secondary electron multiplier; in some set-ups (also) a Faraday cup can be used. Single-collector (scanning mass spectrometer usually used for quantitative elemental analysis) or multicollector (static operation of mass spectrometer for precise isotope ratio analysis) configurations can be found (Figures 12.1 and 12.2).

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“…The systematic metal ion concentration was measured according to a well-established protocol (Krachler et al, 2009) using high-resolution inductively coupled plasma-mass spectrometry (HR-ICP-MS) (Element2; Thermo Fisher Scientifi c, Bremen, Germany) with a detection limit of 0.03 μ g/l for cobalt and 0.05 g/l for chromium.…”

Section: Wear Measurementmentioning

confidence: 99%