Aim: Reduction of duration of untreated psychosis (DUP) remains a key goal of early intervention programs. While a significant body of literature suggests that a short DUP has a positive impact on outcome, little is known regarding the threshold above which various dimensions of outcome are impaired. In this study, we explore the DUP threshold that best discriminates subgroups with poorer outcome regarding global functioning and quality of life after 3 years of treatment.Method: A total of 432 patients were followed-up prospectively over 3 years. Several hypothetical cut-off points for DUP were tested in order to maximize differences in effect size for quality of life and general functioning.Results: While a DUP cut-off of 86 weeks defined two subpopulations with a difference of greatest effect size in quality of life after 3 years, it is already at a cut-off of 3 weeks of DUP that two subpopulations with a difference in global functioning of the greatest effect size was reached.
Conclusion:DUP seems to have a differential impact on the various components of outcome, and in particular on quality of life and global functioning. Our data suggest that aiming at very short DUP is justified, but that DUP over 3 weeks are still compatible with good quality of life after 3 years of treatment.duration of untreated psychosis, early intervention, functioning, quality of life
| INTRODUCTIONDelay between psychosis onset and exposure to appropriate treatment or 'duration of untreated psychosis' (DUP), has been identified as a key target in specialized early intervention programs in the early phase of psychotic disorders (Joa et al., 2007;Melle et al., 2008;NHS, 2015). This is based on the assumption that its reduction may have a positive impact on the course of symptoms and functioning (Melle et al., 2008).Several papers have shown DUP to be significantly associated with outcomes: these studies reported lower severity of symptoms, better functioning and quality of life, as well as higher remission rates in patients with shorter DUP (