Validation study of the claims-based definition for age-related macular degeneration at a single university hospital in Japan

Tamiya, Ryosuke; Miyake, Masahiro; Kido, Ai; Hiragi, Shusuke; Tamura, Hiroshi; Kuroda, Tomohiro; Tsujikawa, Akitaka

doi:10.1007/s10384-021-00816-w

Cited by 9 publications

(9 citation statements)

References 16 publications

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“…Full‐text articles of 42 studies were retrieved, and six were excluded because they compared aggregate data, validated self‐report questionnaires using claims data as a reference standard, were review articles, were aimed at refining the cancer registry and not for research purposes, did not report case‐defining methods, or did not report a reference standard 12,19–23 . There were 36 eligible studies, including 29 studies 8,10,11,13,24–48 that validated administrative data using an external reference standard and seven studies 9,49–54 that validated administrative data using other data within the same database.…”

Section: Resultsmentioning

confidence: 99%

Validation studies of Japanese administrative health care data: A scoping review

Yamana

Konishi

Yasunaga

2023

Pharmacoepidemiology and Drug

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Purpose Large‐scale administrative health care databases are increasingly being utilized for research. However, there has not been much literature that validated administrative data in Japan; a previous review identified six validation studies published between 2011 and 2017. We conducted a literature review of studies that assessed the validity of Japanese administrative health care data. Methods We searched for studies published by March 2022 that compared individual‐level administrative data with a reference standard from another data source, as well as studies that validated administrative data using other data within the same database. The eligible studies were also summarized based on characteristics which included data types, settings, reference standard used, numbers of patients, and conditions validated. Results There were 36 eligible studies, including 29 that used external reference standard and seven that validated administrative data using other data within the same database. Chart review was the reference standard in 21 studies (range of the numbers of patients, 72–1674; 11 studies conducted in single institutions and nine studies in 2–5 institutions). Five studies used a disease registry as the reference standard. Diagnoses of cardiovascular diseases, cancer, and diabetes were frequently evaluated. Conclusions Validation studies are being conducted at an increasing rate in Japan, although most of them are small scale. Further large‐scale comprehensive validation studies are necessary to effectively utilize the databases for research.

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Section: Resultsmentioning

confidence: 99%

Validation studies of Japanese administrative health care data: A scoping review

Yamana

Konishi

Yasunaga

2023

Pharmacoepidemiology and Drug

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“…Following previous validation studies, we defined diagnosis based on chart reviews as the reference standard 11,13,19,20. Because the quality of the descriptions in the charts affects the quality of the chart reviews, we took 2 measures.…”

Section: Discussionmentioning

confidence: 99%

“…Following previous validation studies, we defined diagnosis based on chart reviews as the reference standard. 11,13,19,20 Because the quality of the descriptions in the charts affects the quality of the chart reviews, we took 2 measures. First, the reviewers made judgments based not only on the recorded diagnoses in the charts but also on the results of objective ophthalmic examinations.…”

Section: Discussionmentioning

confidence: 99%

Validity of Algorithms to Identify Patients With Glaucoma Using the Japanese Claims Data

Fujita

Aoyama

Yamana

et al. 2022

Journal of Glaucoma

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Précis: Diagnostic or antiglaucoma drug records in the Japanese claims data showed a high validity in identifying glaucoma patients. Specific subtypes were identified with high specificity and negative predictive values but low sensitivity and positive predictive values. Purpose: Despite the widespread use of administrative claims data in epidemiological research on glaucoma, only a few studies have investigated the validity of the methods in defining patients with glaucoma using diagnoses and drug records. We aimed to evaluate the validity of these algorithms in identifying patients with glaucoma using the Japanese claims data. Methods: Two ophthalmologists independently reviewed the medical charts and administrative claims data of 500 randomly selected patients who visited the Department of Ophthalmology of an academic hospital in 2019. We constructed 12 algorithms to identify patients with any type and specific subtypes of glaucoma using the claims records of diagnosis, antiglaucoma drugs, and visual field tests. We regarded the diagnosis of glaucoma based on the medical charts as the reference standard and calculated the sensitivity, specificity, and positive and negative predictive values of each algorithm based on the claims data. Results: The algorithms of ≥1 diagnostic record per year and ≥1 antiglaucoma drug record per year exhibited sensitivities of 94.6% and 89.2%, respectively, and specificities of 88.9% and 98.3%, respectively. An increase in the frequency of records resulted in a decreased sensitivity and slightly increased specificity. The addition of visual field tests did not improve the validity. The algorithms for specific subtypes of glaucoma exhibited high specificity and relatively low sensitivity. Conclusion: Diagnostic or antiglaucoma drug records in the Japanese claims data were useful for identifying patients with glaucoma. Researchers should select identification algorithms based on the study design.

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“…A validation study exhibited high accuracy (sensitivity, 94.9%; specificity, 92.6%; accuracy, 93.7%) of the recorded diagnosis of age‐related macular degeneration in a Japanese administrative claims database (Tamiya et al. 2021). Since both age‐related macular degeneration and RVO are diagnosed by fundus examination and fluorescent fundus angiography, the claims‐based definition of RVO could be expected to be as high as that of age‐related macular degeneration.…”

Section: Discussionmentioning

confidence: 99%

Association between proteinuria and retinal vein occlusion in individuals with preserved renal function: a retrospective cohort study

Fujita

Hashimoto

Okada

et al. 2022

Acta Ophthalmologica

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Purpose To investigate the association between proteinuria and the incidence of retinal vein occlusion (RVO) in individuals with preserved renal function. Methods We conducted a retrospective cohort study from 2005 to 2020 using the JMDC Claims Database, a large database of health check‐ups and administrative claims in Japan. Individuals who underwent annual health check‐ups were included. Participants were classified into three groups based on the protein concentration in their urine: negative (≤10 mg/dl), trace (10–30 mg/dl) and positive (≥30 mg/dl). We estimated hazard ratios (HRs) for the development of RVO using Cox regression analyses with adjustment for baseline characteristics by the matching weights calculated from the multiple propensity scores. The cumulative incidence of RVO between the weighted groups was calculated using the Kaplan–Meier estimator. Results There were 1 635 212 eligible participants, among whom 2360 developed RVO. The mean follow‐up period was 1036 ± 951 days. The adjusted HRs for RVO were 1.10 (95% confidence interval 0.92–1.33) and 1.46 (1.19–1.78) in the groups with trace and positive proteinuria compared with negative proteinuria respectively. The cumulative incidence rates of RVO at 7 years were 0.40%, 0.43% and 0.55% in the groups with negative, trace and positive proteinuria, respectively. Conclusion Positive proteinuria was independently associated with an increased incidence of RVO in individuals with preserved renal function. Proteinuria may be a novel risk factor for RVO development.

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Validation study of the claims-based definition for age-related macular degeneration at a single university hospital in Japan

Cited by 9 publications

References 16 publications

Validation studies of Japanese administrative health care data: A scoping review

Validation studies of Japanese administrative health care data: A scoping review

Validity of Algorithms to Identify Patients With Glaucoma Using the Japanese Claims Data

Association between proteinuria and retinal vein occlusion in individuals with preserved renal function: a retrospective cohort study

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