Validation study of ultrasound bladder wall thickness measurements

Asfour, Victoria; Gibbs, Kayleigh; DaSilva, Ana Sophia; Fernando, Ruwan; Digesu, G. Alessandro; Khullar, Vik

doi:10.1007/s00192-018-3802-4

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…The bladder wall is relatively weak, with thickness measurements ranging from 1mm to 15mm in 25 adult cadavers ( 20 ). Therefore, deeper resection may be accompanied by a higher risk of bladder perforation and severe bleeding.…”

Section: Discussionmentioning

confidence: 99%

Transurethral en bloc resection with monopolar current for non-muscle invasive bladder cancer based on TNM system

Yang¹,

Liu²,

Yang³

et al. 2020

Transl Cancer Res TCR

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Background To evaluate the surgical safety and quality of transurethral en bloc resection with monopolar current for non-muscle invasive bladder cancer (NMIBC) based on the tumour, node, metastasis (TNM) classification system, and report the midterm oncological outcome. Methods From October 2015 to June 2017, en bloc resection of bladder tumor (ERBT) and transurethral resection of bladder tumor (TURBT) were performed in 96 and 87 patients clinically diagnosed with NMIBC in the prospective case-control trial, respectively. Operative details, intraoperative and postoperative complications regarded as safety outcomes were documented. The quality of ERBT was judged by the histopathological examination of tumor specimens from initial resection and second TURBT, random bladder biopsy and follow-up recurrence rate. Results Operative time, obturator nerve reﬂex, irrigation and catheterization time were similar in the two groups. Bladder perforation was occurred in 2 patients during ERBT and 9 patients during TURBT (2/96 vs. 9/87, P=0.019). Compared with TURBT group, the ratio of detrusor muscle (DM) identified in pathologic T1 tumor specimens was higher (P=0.024), but lower in pathologic Ta tumor specimens in ERBT group (P<0.001). The residual tumor identified in ERBT group was lower than that in TURBT group during second TURBT (2/28 vs. 10/32, P=0.020). The recurrence-free survival rate did not differ significantly between the two groups after 24 months follow-up. Conclusions ERBT based on TNM system is a safe and feasible technique to treat patients with NMIBC. Besides, ERBT may reduce the proportion of bladder perforation and residual tumor during initial resection.

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Section: Discussionmentioning

confidence: 99%

Transurethral en bloc resection with monopolar current for non-muscle invasive bladder cancer based on TNM system

Yang¹,

Liu²,

Yang³

et al. 2020

Transl Cancer Res TCR

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“…The COMs dramatically decreased after 6‐weeks' obstruction but slightly decreased after 3 weeks' obstruction (Figure A‐F). In the previous study, the thickness of the DM was measured at the thickest part of the bladder, so we also choose to measure the thickest part of the bladder at the same section in all bladders, and it is also significantly thickened after both 3 and 6‐weeks' pBOO (Figure G‐H). Meanwhile, the bladder weight(mg)/body weight(g) ratios significantly increased in both 3‐week group and 6‐week group (Figure S1).…”

Section: Resultsmentioning

confidence: 99%

Responses of bladder smooth muscle to the stretch go through extracellular signal‐regulated kinase (ERK)/p90 ribosomal S6 protein kinase (p90RSK)/Nuclear factor‐κB (NF‐κB) Pathway

Lin

et al. 2019

Neurourology and Urodynamics

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Aims The present study was designed to study changes and its potential mechanisms in human bladder smooth muscle subjected to stretch. Methods Bioinformatics analyses including differential expression analysis, overrepresentation enrichment analysis, principal component analysis, and weighted gene coexpression network analysis were used to analyze a microarray dataset (GSE47080) of partial bladder outlet obstruction (pBOO) in rat to find the potential changes of gene expressions. Bladder from pBOO model and human bladder smooth muscle cells (HBSMCs) subjected to sustained prolonged stretch were collected for Western blot analysis, real‐time polymerase chain reaction, and fluorescence analysis to verify the changes of gene expressions and preliminarily study the potential role of signaling pathway regulation in treatment of pBOO. Results The bioinformatics analysis showed that chronic obstruction activated mitogen‐activated protein kinase pathway and changed cytoskeleton structure in bladder smooth muscle. In in vivo experiments in mice, pBOO was verified by cystometry. Partial BOO activated the extracellular signal‐regulated kinase (ERK)/p90 ribosomal S6 protein kinase (p90RSK)/nuclear factor‐κB (NF‐κB) signaling pathway in DM. The messenger RNA (mRNA) expressions of contractile phenotypic proteins increased after pBOO. In in vitro experiments of HBSMCs, mechanical stretch activated ERK/p90RSK/NF‐κB in HBSMCs in a time‐dependent manner. The mRNA expressions of α‐smooth muscle actin and SM22 also increased and filamentous actin (F‐actin) polymerization was enhanced as well. Inhibition of ERK/p90RSK/NF‐κB pathway reversed mechanical stretch‐induced changes of contractile phenotypic expression and F‐action polymerization. Conclusions Continuous stretch increases expressions of contractile phenotypic proteins and promotes the polymerization of F‐actin. This process partially goes through ERK/p90RSK/NF‐κB pathway.

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“…This is due to the type's ease of absorption by water on target tissue and superior hemostasis capabilities.(X. Chen et al, 2015) Because of the relatively weak bladder wall, with a thickness ranging from 1mm to 15mm in 25 adult cadavers, (Asfour et al, 2019) conventional TURBT requires deeper resection, which can result in a higher risk of bladder perforation and severe bleeding, increasing the recurrence rate and progression of the tumour. (Huang et al, 2016; In the En-bloc technique using a laser, the current enters slowly, resulting in minimal thermal injury (with temperatures ranging from 40°C to 75°C), and the resection process is performed slowly to control depth.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of En-Bloc and Conventional Transurethral Resection of Bladder Tumor (TURBT) for Non-Muscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis

Reynaldo,

Monoarfa,

Duha

2024

jika

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In order to treat non-muscle invasive bladder cancer, this study will compare and contrast conventional transurethral resection of bladder tumors (TURBT) with En-bloc resection (ERBT). It will also assess the efficacy, safety, and recurrence rates of these two methods. We searched PubMed and Sience Direct for relevant articles published between 2013 and 2023. Articles from randomized controlled trials, retrospective analyses, and prospective studies comparing non-muscle invasive bladder cancer therapies employing en bloc versus conventional TURBT are included in this analysis. Measuring effect size was done using Mean Difference (MD) and Odd Ratio (OR) with 95% CI. There is statistical significance when the p-value is less than 0.05. Fourteen studies were eligible for inclusion. With fewer tumor recurrences (OR 0.66; 95% [CI] 0.52, 0.84; I2 = 6%; P = 0.0007), ERBT proved to be superior to TURBT. There was a decrease in the occurrence of perioperative complications and outcomes associated with ERBT, including bladder perforation and obturator nerve injury. According to the fourteen articles that were included, patients receiving ERBT experienced much fewer complications, recurrences, hospital stays, and catheterization time than those receiving conventional TURBT.

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Validation study of ultrasound bladder wall thickness measurements

Cited by 8 publications

References 9 publications

Transurethral en bloc resection with monopolar current for non-muscle invasive bladder cancer based on TNM system

Transurethral en bloc resection with monopolar current for non-muscle invasive bladder cancer based on TNM system

Responses of bladder smooth muscle to the stretch go through extracellular signal‐regulated kinase (ERK)/p90 ribosomal S6 protein kinase (p90RSK)/Nuclear factor‐κB (NF‐κB) Pathway

Comparative Analysis of En-Bloc and Conventional Transurethral Resection of Bladder Tumor (TURBT) for Non-Muscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis

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