The purpose of this study was to explore the value of extended care based on a biopsychosocial medicine model in patients with abnormal tumor markers on physical examination. One hundred and fifty-two cases with abnormal primary screening tumor markers who were examined in our medical examination center between January 2020 and January 2022 were selected as the subjects of this study and divided into intervention and control groups according to the random number table method, with 76 cases in each group. The control group was given the usual extended care intervention and the intervention group was given the extended care intervention based on the biopsychosocial medicine model. The compliance rates of regular follow-up, reasonable diet, appropriate exercise, and regular rest were compared between the two groups. After the intervention, the disease-related knowledge score in the intervention group was higher than that in the control group (
P
<
0.05
). The compliance rates of regular return visits, reasonable diet, appropriate exercise, and regular routines in the intervention group were higher than those in the control group (
P
<
0.05
). After the intervention, the scores of psychological states such as anxiety, depression, and post-traumatic growth in the intervention group were better than those in the control group (
P
<
0.05
). After the intervention, the total scores of objective support, subjective support, support utilization, and social support in the intervention group were higher than those in the control group (
P
<
0.05
). After the intervention, the intervention group had higher positive coping scores and lower negative coping scores than the control group (
P
<
0.05
). Continuing care based on the biopsychosocial model of medicine is effective in people with abnormal tumor markers on medical screening. It can improve the knowledge about the disease, increase the compliance rate, improve negative emotions, psychological status, and social support, and promote a more positive way of responding.