Validity and reliability of the revised neuropsychological impairment scale (NIS)

O'Donnell, William E.; Soto, Clinton B. De; Soto, Janet L. de

doi:10.1002/1097-4679(199305)49:3<372::aid-jclp2270490311>3.0.co;2-k

Cited by 16 publications

(14 citation statements)

References 15 publications

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“…In turn, NCI symptoms will worsen in HIV-infected people not taking ART [71], because ART reverses some, but not all NCI-related symptoms [72]. Although the general measure of NCI did not remain significant in the multivariate model, it is possible that only the most severely neurocognitively impaired (e.g., worst decile) [43] or those with impairment of only one or a few of the cognitive domains (e.g., memory, learning ability, attention) [44] show suboptimal ART adherence [73]. Further exploration of NCI severity and NCI subscales on ART adherence is warranted.…”

Section: Discussionmentioning

confidence: 99%

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Alcohol use disorders negatively influence antiretroviral medication adherence among men who have sex with men in Peru

et al. 2014

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Objective-As international guidelines increase access to antiretroviral therapy (ART) globally, ART adherence becomes increasingly important to achieve HIV treatment as prevention (TasP) goals. In the concentrated HIV epidemic among men who have sex with men (MSM) and transgendered women (TGW) in Lima, Peru, the independent correlates of ART non-adherence were examined to inform treatment intervention priorities.Design-Cross sectional survey of HIV-infected MSM and TGW who are engaged in clinical care in Lima, Peru. Methods-FromJune to August 2012, 302 HIV-infected Peruvian MSM/TGW from three clinical care sites were recruited using convenience sampling to participate in a cross-sectional computer-assisted adherence survey. Several standardized screening measures associated with ART non-adherence were examined in order to determine the independent correlates of optimal (≥90%) and perfect (100%) adherence, which were assessed using logistic regression.Results-Of the 302 participants recruited, 263 (87.1%) were prescribed ART. Among those prescribed ART, 229 (87.1%) reported optimal and 146 (55.5%) reported perfect adherence. The prevalence of alcohol use disorders (AUD; 43.2%), alcohol dependence (5.3%), recent drug use (6.0%) and depression (44.5%) was high and most participants had some evidence of neurocognitive impairment. Meeting criteria for having an AUD and depression were collinear (p<0.001). On multivariate analysis, having an AUD was inversely related and the only Conclusions-AUDs are highly prevalent among Peruvian HIV-infected MSM and contribute significantly to ART non-adherence. These findings support the need for screening and treating underlying AUDs. In order to meet HIV TasP goals, evidence-based strategies targeting AUDs are likely to directly improve ART adherence and indirectly improve overall individual health, HIV treatment engagement and reduce transmission to sexual partners among this vulnerable and disproportionally affected population.

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Section: Discussionmentioning

confidence: 99%

“…NCI was assessed using the 95-item standardized Neuropsychological Impairment Scale (NIS) [43]. Though the NIS features many subscales, we focused only on the influence of general cognitive impairment, which was analyzed using a validated NCI summary score called the Global Measure of Impairment (GMI).…”

Section: Methodsmentioning

confidence: 99%

Alcohol use disorders negatively influence antiretroviral medication adherence among men who have sex with men in Peru

et al. 2014

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“…Study measurements included instruments evaluating addiction severity (Addiction Severity Index 5 th edition, ASI), 64 mental health (psychiatrist-administered Mini International Neuropsychiatric Interview, MINI, 58 and the Center for Epidemiological Studies Depression Scale, CES-D, 65 alcohol use disorders (WHO AUDIT), 66 neuropsychological impairment, 67,68 HIV symptoms, 69 health-related quality of life (SF-36), 61–63 social support (MOS social support survey), 70 HIV stigma (Berger HIV stigma scale), 71 trust in physicians, 72 sexual and drug-related HIV risk behaviors, medical and drug treatment history, involvement with the criminal justice system, and attitudes toward drug treatment.…”

Section: Methodsmentioning

confidence: 99%

Design and implementation of a factorial randomized controlled trial of methadone maintenance therapy and an evidence-based behavioral intervention for incarcerated people living with HIV and opioid dependence in Malaysia

Bazazi

Wickersham

Wegman

et al. 2017

Contemporary Clinical Trials

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Incarcerated people living with HIV and opioid dependence face enormous challenges to accessing evidence-based treatment during incarceration and after release into the community, placing them at risk of poor HIV treatment outcomes, relapse to opioid use and accompanying HIV transmission risk behaviors. Here we describe in detail the design and implementation of Project Harapan, a prospective clinical trial conducted among people living with HIV and opioid dependence who transitioned from prison to the community in Malaysia from 2010 to 2014. This trial involved 2 interventions: within-prison initiation of methadone maintenance therapy and an evidence-based behavioral intervention adapted to the Malaysian context (the Holistic Health Recovery Program for Malaysia, HHRP-M). Individuals were recruited and received the interventions while incarcerated and were followed for 12 months after release to assess post-release HIV transmission risk behaviors and a range of other health-related outcomes. Project Harapan was designed as a fully randomized 2×2 factorial trial where individuals would be allocated in equal proportions to methadone maintenance therapy and HHRP-M, methadone maintenance therapy alone, HHRP-M alone, or control. Partway through study implementation, allocation to methadone maintenance therapy was changed from randomization to participant choice; randomization to HHRP-M continued throughout. We describe the justification for this study; the development and implementation of these interventions; changes to the protocol; and screening, enrollment, treatment receipt, and retention of study participants. Logistical, ethical, and analytic issues associated with the implementation of this study are discussed.

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“…Prior to our EFA, we evaluated the peer-reviewed literature on the development and validation of the original (O'Donnell, de Soto, & Reynolds, 1984; O'Donnell, Reynolds, & de Soto, 1983, 1984) and revised (O'Donnell, de Soto, & de Soto, 1993) versions of the NIS (O'Donnell et al, 1993; O'Donnell, de Soto, et al, 1984; O'Donnell et al, 1983) as well as the NIS user manual. We noted that 15 of the 95 NIS items are designed to function as “validity checks” to distinguish a participant’s potential response set or psychological symptoms that are unrelated to neurocognitive impairment, yet may cloud the ability to detect it, including: Defensiveness (e.g., “I am always happy” and “I always tell the truth”) and Affective Disturbance (e.g., “I tend to worry all the time” and “I feel quite discouraged about my future”).…”

Section: Methodsmentioning

confidence: 99%

An Exploratory Factor Analysis of a Brief Self-Report Scale to Detect Neurocognitive Impairment Among Participants Enrolled in Methadone Maintenance Therapy

Copenhaver

Shrestha

Wickersham

et al. 2016

Journal of Substance Abuse Treatment

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The present study examines the factor structure of the existing Neuropsychological Impairment Scale (NIS) through the use of exploratory factor analysis (EFA). The NIS is a brief self-report measure originally designed to assess neurocognitive impairment (NCI) by having patients rate a range of items that may influence cognitive functioning. Stabilized patients on methadone maintenance therapy (MMT; N=339) in New Haven, CT who reported drug- or sex-related HIV risk behaviors in the past 6 months were administered the full 95-item NIS. An EFA was then conducted using principal axis factoring and orthogonal varimax rotation. The EFA resulted in retaining 57 items, with a 9-factor solution that explained 54.8% of the overall variance. The revised 9-factor measure - now referred to as the Brief Inventory of Neuro-cognitive Impairment (BINI) - showed a diverse set of factors with excellent to good reliability (i.e., F1 α = 0.97 to F9 α = 0.73). This EFA suggests the potential utility of using the BINI in the context of addiction treatment. Further research should examine the utility of this tool within other clinical care settings.

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Validity and reliability of the revised neuropsychological impairment scale (NIS)

Cited by 16 publications

References 15 publications

Alcohol use disorders negatively influence antiretroviral medication adherence among men who have sex with men in Peru

Alcohol use disorders negatively influence antiretroviral medication adherence among men who have sex with men in Peru

Design and implementation of a factorial randomized controlled trial of methadone maintenance therapy and an evidence-based behavioral intervention for incarcerated people living with HIV and opioid dependence in Malaysia

An Exploratory Factor Analysis of a Brief Self-Report Scale to Detect Neurocognitive Impairment Among Participants Enrolled in Methadone Maintenance Therapy

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