Validity of 13C octanoic acid breath test for measurement of solid meal gastric emptying time in children

Eradi, Bala; Wright, Jeff; Gibbons, Nicola J.; Blackshaw, P. E.; Perkins, Alan C.; Wakefield, Jennifer C.; Sithole, Jabulani; Singh, Sonali

doi:10.1016/j.jpedsurg.2006.08.006

Cited by 18 publications

(26 citation statements)

References 20 publications

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“…All 5-10 years old (mean 8.1 ± 1.76, n = 25) showed a mean GET 1/2 of 107.2 min (range 54.6-159.8 min). A further study showed excellent reproducibility using the labelled crispy cake both by scintigraphy and carbon breath test (Eradi et al, 2006).…”

Section: Gastric-emptying Timementioning

confidence: 91%

Specific aspects of gastro-intestinal transit in children for drug delivery design

Bowles

Keane²,

Ernest

et al. 2010

International Journal of Pharmaceutics

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Section: Gastric-emptying Timementioning

confidence: 91%

Specific aspects of gastro-intestinal transit in children for drug delivery design

Bowles

Keane²,

Ernest

et al. 2010

International Journal of Pharmaceutics

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“…In contrast to 99-Technetium scintigraphy, the former gold standard for GE, it offers normal values for children of all ages, both genders, and liquid and solid intake. Additionally, 13C GEBT does not involve radiation and is therefore suitable for large pediatric study populations 13. The intra-individual variability of the 13C GEBT has been studied in multiple studies.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Gastrostomy Placement on Gastric Function in Children: a Prospective Cohort Study

Franken

Mauritz

Stellato

et al. 2017

Journal of Gastrointestinal Surgery

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BackgroundA gastrostomy placement is frequently performed in pediatric patients who require long-term enteral tube feeding. Unfortunately, postoperative complications such as leakage, feeding intolerance, and gastroesophageal reflux frequently occur. These complications may be due to postoperative gastric dysmotility. Our aim was to evaluate the effect of gastrostomy placement on gastric emptying in children.MethodsA prospective study was performed including 50 children undergoing laparoscopic gastrostomy. Before and 3 months after gastrostomy, assessment was performed using the 13C-octanoic acid breath test, 24-h pH monitoring, and reflux symptom questionnaires.ResultsGastric half-emptying time significantly increased from the 57th to the 79th percentile (p < 0.001) after gastrostomy (p < 0.001). Fifty percent of patients with normal preoperative gastric emptying develop delayed gastric emptying (DGE, P > 95) after gastrostomy (p = 0.01). Most patients (≥75%) with leakage and/or feeding intolerance after gastrostomy had DGE after operation. A decrease in gastric emptying was associated with an increase in esophageal acid exposure time (r = 0.375, p < 0.001).ConclusionGastrostomy placement in children causes a significant delay in gastric emptying. Postoperative DGE was associated with gastroesophageal reflux and was found in most patients with postoperative leakage and feeding intolerance. These negative physiologic effects should be taken into account when considering gastrostomy placement in children.

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“…Breath tests using the stable, non‐radioactive isotope 13 C given in a substrate such as octanoic acid or the plant Spirulina platensis have been used successfully in adults and children to assess gastric emptying . Their cost is similar to scintigraphy .…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

Childhood gastroparesis is a unique entity in need of further investigation

Febo‐Rodriguez

Chumpitazi

Shulman

2019

Neurogastroenterology Motil

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Background Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP‐specific pediatric reported outcome measures. Purpose The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co‐morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric‐focused therapies.

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Validity of 13C octanoic acid breath test for measurement of solid meal gastric emptying time in children

Cited by 18 publications

References 20 publications

Specific aspects of gastro-intestinal transit in children for drug delivery design

Specific aspects of gastro-intestinal transit in children for drug delivery design

The Effect of Gastrostomy Placement on Gastric Function in Children: a Prospective Cohort Study

Childhood gastroparesis is a unique entity in need of further investigation

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