Validity of 6&lt;sup&gt;th&lt;/sup&gt; edition of UICC TNM classification system for medullary thyroid carcinoma: A proposal for intraoperative evaluation of T category

Ito, Yasuhiro; Kihara, Minoru; Hirokawa, Mitsuyoshi; Takamura, Yuuki; Kobayashi, Kaoru; Miya, Akihiro; Miyauchi, Akira

doi:10.1507/endocrj.ej12-0031

Cited by 3 publications

(2 citation statements)

References 30 publications

(24 reference statements)

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“…Pathological findings were directly obtained from the original histopathology reports. All tumours were staged according to the 7th edition of the UICC classification ( Ito et al , 2012 ). Samples from earlier surgeries were adjusted to this staging system to ensure conformity and reproducibility.…”

Section: Methodsmentioning

confidence: 99%

Survivin and XIAP: two valuable biomarkers in medullary thyroid carcinoma

et al. 2016

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Background:Medullary thyroid carcinoma (MTC) accounts for ∼5% of all thyroid malignancies. To date, surgery is the first-line therapy with curative intention. However, for advanced MTC, conventional chemotherapeutic agents do not provide convincing results. Therefore, the identification of biomarkers that can be antagonised by small-molecule therapeutics may lead to novel encouraging treatment options.Methods:Seventy-nine patients with surgically resected and histologically confirmed MTC were included in this study. Tissue microarrays were constructed to assess the relationship between inhibitor of apoptosis proteins (IAPs) survivin or XIAP expression levels and clinicopathological variables as well as overall survival.Results:High survivin or XIAP expression was associated with an advanced T-stage and metastatic disease. Whereas tissue expression levels of survivin correlated with serum calcitonin levels, XIAP was overexpressed in the subgroup of patients with sporadic MTC. Both IAPs were negatively associated with patient survival in the multivariate Cox regressions analysis (survivin: hazard ratio (HR) 1.62; 95% confidence interval (CI): 1.21–2.16; P=0.001; XIAP: HR 1.78; 95% CI: 1.16–2.72; P=0.008).Conclusions:Survivin and XIAP demonstrate distinct expression patterns in MTCs, which are associated with advanced disease and poor prognosis. We thus provide first evidence that both IAPs might serve as viable targets in patients with MTC.

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Section: Methodsmentioning

confidence: 99%

Survivin and XIAP: two valuable biomarkers in medullary thyroid carcinoma

et al. 2016

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“…Despite the growing data suggesting that de-escalation of treatment is possible, most guidelines, except for the recent guidelines from Japan, continue to recommend total thyroidectomy for sporadic medullary cancer . While the 2015 American Thyroid Association medullary thyroid guidelines recommend total thyroidectomy and central neck dissection when the diagnosis of medullary thyroid cancer is known preoperatively, they also allow for a more conservative management approach when low-risk intrathyroidal sporadic medullary thyroid cancer is only detected postoperatively.…”

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confidence: 99%

Precision Thyroidectomy in Sporadic Medullary Thyroid Cancer

Shaha,

Davies,

Tuttle

2024

JAMA Otolaryngol Head Neck Surg

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Association between TNM staging system and histopathological features in patients with papillary thyroid carcinoma

2014

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We aimed to assess the validity of the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging system in patients with papillary thyroid carcinoma (PTC) by evaluating the relationships between clinicopathologic factors and TNM stage using histopathological specimens and electronic medical records. We enrolled 733 consecutive patients who had undergone thyroid surgery for PTC between 2010 and 2013. Clinical data were obtained from electronic medical records. TNM stages, multifocality, and bilaterality were analyzed after review of histopathological specimens by applying the AJCC TNM staging system. Multiple statistical analyses were performed to evaluate the correlation between the AJCC TNM staging system and the clinicopathologic factors. Of the 733 patients, there were T stage including T1a (46.9 %, 344/733), T1b (12.6 %, 92/733), T2 (2.0 %, 15/733), T3 (38.1 %, 279/733), T4a (0.4 %, 3/733), and T4b (0 %, 0/733), N stage including N0 (58.9 %, 432/733), N1a (24.3 %, 178/733), and N1b (16.8 %, 123/733), and multiplicity including multifocality (31.1 %, 228/733) and bilaterality (23.7 %, 174/733). There was a significant association between the PTC primary tumor size and T stage, N stage, multifocality, and bilaterality (p < 0.0001). Multifocality, bilaterality, and the presence of nodal metastasis were most frequently seen in patients with T3 stage (p < 0.0001). In multivariate logistic regression analyses, T and N stages were independent predictors of multiple PTCs. The PTC primary tumor size had a significant association with the T and N stages of the AJCC TNM staging system, and these factors were independent predictors of multifocality and bilaterality.

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Validity of 6<sup>th</sup> edition of UICC TNM classification system for medullary thyroid carcinoma: A proposal for intraoperative evaluation of T category

Cited by 3 publications

References 30 publications

Survivin and XIAP: two valuable biomarkers in medullary thyroid carcinoma

Survivin and XIAP: two valuable biomarkers in medullary thyroid carcinoma

Precision Thyroidectomy in Sporadic Medullary Thyroid Cancer

Association between TNM staging system and histopathological features in patients with papillary thyroid carcinoma

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