Validity of antagonism of different effects of reserpine as test for anti-depressant activity

Synthesis and biological activity of pyrimido [1, 2-a] quinoline moiety and its 2-substituted derivatives

“…Despite its relatively low efficacy and tolerability, quinine still plays an important role in the treatment of multi resistant malaria 1 . Quinoline and its derivatives are receiving important due to their due to wide range of biological activities as a drug analgesics 2 ,antiamoebic [3][4][5][6] , tryphocidal 7 , antiseptic 8 and antiserotonin 9 .In addition to these, derivatives also exhibit good antimalarial 10,11 , antitubercular 12 , antibacterial 13 , antihistaminic 14 , antineurodegerative 15 , anticonvulsant 16 , antitumor 17 , anticancers [18][19][20] and antiallergics 21 activities. In view of these observations, such as quinoline fused with pyrimidine ring would exhibit some interesting pharmacological activities, further, the ring anellation to amino groups containing nitrogen heterocycles with ketene dithioacetals as reagent has reported [22][23] .…”

Synthesis and Antimicrobial Activity of 3‐Cyano‐4‐imino‐9‐methoxy‐4H‐pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2‐Substituted Derivatives

“…is molecule has also played a historical role in organic chemistry as a target for structural determination and total synthesis [1] and recently both stereoselective [2] and enantioselective [3] total syntheses. Quinoline and its derivatives are receiving important due to their wide range of biological activities as a drug analgesics [4], antiamoebic [5][6][7][8], trypanocidal [9], antiseptic [10], and antiserotonin [11]. In addition to these, derivatives also exhibit good antimalarial [12,13], antitubercular [14], antibacterial [15], antihistaminic [16], anti-neurodegerneative [17], anticonvulsant [18], antitumor [19], anticancers [20,21], and antiallergics [22] activities.…”