Validity of Cancer Antigen-125 (CA-125) and Risk of Malignancy Index (RMI) in the Diagnosis of Ovarian Cancer

Al-Musalhi, K.; Al-Kindi, Manal; Ramadhan, Fatma; Al-Rawahi, Thuraya; Al-Hatali, Khalsa; Mula-Abed, Waad-Allah S.

doi:10.5001/omj.2015.85

Cited by 28 publications

(20 citation statements)

References 21 publications

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“…Carbohydrate antigen 125 (CA‐125), also known as mucin 16 (MUC16), is a member of the mucin glycoproteins which contains 22,000 amino acids. It is significantly expressed by most ovarian epithelial tumors, but also by the normal epithelium of the female reproductive system, gastrointestinal mucosal cells, and by the luminal surface of the mesothelium lining the peritoneum, pleura and pericardium …”

Section: Eis As a Powerful Tool For Sensitive Detection Of Cancer Biomentioning

confidence: 99%

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

et al. 2018

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affinity biosensors are, without any doubt, among the most sensitive analytical devices available, offering low limits of detection and wide linear response ranges. There are, however, only a few papers detailing the application of impedimetric biosensors for the analysis of clinically relevant samples with due clinical performance. The fact that these devices have not found their way to any commercial or clinical use to date might be surprising, since an electrochemical assay platform based on portable potentiostats is a success story for monitoring a range of clinical parameters such as ions, haematological indicators and glucose. This review discusses the reasons behind this discrepancy and addresses the barriers to be overcome in order to achieve the point-of-care diagnostics using such devices for detection of protein oncomarkers approved by FDA. The final part of the review covers the most recent progress in the area.[a] Dr.

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Section: Eis As a Powerful Tool For Sensitive Detection Of Cancer Biomentioning

confidence: 99%

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

et al. 2018

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“…5,6 Approximately 80-90% of all the pathological ovarian masses are benign and mostly occur in young women between 20 and 45 years whereas the borderline and malignant tumors are common in postmenopausal women. 2,[7][8][9] Ovarian tumors are divided into three major categories: epithelial, germ cell, and sex cord-stromal tumors.10 and mostly, physiological cysts are follicular and luteal cysts. 11 The studies showed a large variation and diversity in prevalence, types of ovarian masses and histological patterns of them.…”

Section: Introductionmentioning

confidence: 99%

“…11 The studies showed a large variation and diversity in prevalence, types of ovarian masses and histological patterns of them. [4][5][6][7][8][9][10][11][12] Kayastha et al demonstrated the incidence of benign tumor as 90.5% in Nepal. 13 Pradhan SB et al showed the incidence of benign ovarian tumors as 86.8 percent.…”

Section: Introductionmentioning

confidence: 99%

Histopathological diagnosis of ovarian mass

Shahali

Tadayon

2018

J Pathol Nep

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Background: Ovarian cysts are common forms of gynecological problems that can be range from physiological cysts to highly aggressive neoplastic lesions. The purpose of this study was to investigate prevalence and frequency of different histopathological patterns of ovarian lesions and their correlation with various parameters in Ahvaz, Iran.Materials and Methods: This is the retrospective study of patients with the ovarian masses at Ahvaz Imam Khomeini Hospital from 2010 - 2015. The relevant clinical details about the patient were retrieved from hospital data. Clinical characteristics of patients such as patient's age, presenting signs and symptoms, histopathological diagnosis, mass type, mass subtype, size of cysts and ovary which is involved were noted. Results: Two hundred sixty seven specimens of ovarian tumor obtained for histopathological examination. Of these, 163(61.0%) were tumor like, 96(36.0%) were benign tumor and 8(3.0%) were malignant. The most common tumor like conditions was Corpus luteum cyst (43.4% cases), among benign and malignant tumors, mature cystic teratoma (17.2% of total) and Epithelial tumors (n=4) were most common. There is a statistically significant positive relation between age and various ovarian masses. (P= 0.002). Histopathological diagnosis wasn't correlated with ovarian involvement.Conclusion: Benign tumors are more common than malignant tumors in all age groups. Germ cell tumors followed by surface epithelial cell tumors are the commonest tumor. Mature cystic teratoma was the most common tumor. Unilaterality is more frequently seen in ovarian tumors and various tumors are seen in various age groups.

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“…Studies had reported variation in the discriminative performance of serum CA-125. One study in Oman reported an AuROC of serum CA-125 at 0.75 for ovarian cancer diagnosis [ 25 ]. Another study in Turkey, reported an AuROC of 0.78 [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125)

et al. 2021

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Background: This study aimed to evaluate the diagnostic added-value of serum CA-125 to the International Ovarian Tumor Analysis (IOTA) Simple Rules in order to facilitate differentiation between malignant and benign ovarian tumors before surgery. Methods: A secondary analysis of a cross-sectional cohort of women scheduled for surgery in Maharaj Nakorn Chiang Mai Hospital between April 2010 and March 2018 was carried out. Demographic and clinical data were prospectively collected. Histopathologic diagnosis was used as the reference standard. Logistic regression was used for development of the model. Evaluation of the diagnostic added-value was based on the increment of the area under the receiver operating characteristic curve (AuROC). Results: One hundred and forty-five women (30.3%) out of a total of 479 with adnexal masses had malignant ovarian tumors. The model that included information from the IOTA Simple Rules and serum CA-125 was significantly more superior to the model that used only information from the IOTA Simple Rules (AuROC 0.95 vs. 0.89, p < 0.001 for pre-menopause and AuROC 0.98 vs 0.83, p < 0.001 for post-menopause). Conclusions: The IOTA SR X CA-125 model showed high discriminative ability and is potentially useful as a decision tool for guiding patient referrals to oncologic specialists.

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Validity of Cancer Antigen-125 (CA-125) and Risk of Malignancy Index (RMI) in the Diagnosis of Ovarian Cancer

Cited by 28 publications

References 21 publications

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

Histopathological diagnosis of ovarian mass

Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125)

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