Validity of carbohydrate‐deficient transferrin (%CDT), γ‐glutamyltransferase (γ‐GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non‐alcoholic and alcoholic origin

Abstract

%CDT is of high diagnostic value to support diagnosis of alcohol-use disorders. The specificity of this marker in patient groups with liver disorders is superior to the biomarkers gamma-GT and MCV.

En kvinne med kraftsvikt i armer og bein

“…Gamma-GT og MCV var ikke forhøyet til tross for alkoholoverforbruk. I studien til Hock og medarbeidere fremkommer det imidlertid at sensitiviteten til disse biomarkørene ikke er veldig høy (12). Forklaringen på pasientens kroniske diaré var trolig ulcerøs kolitt, selv om biopsisvarene ikke var helt konklusive.…”

Alcoholic Cardiomyopathy: Basic Aspects of Epidemiology, Pathogenesis and Pharmacotherapy

“…К непрямым биологическим маркерам злоупо-требления алкоголем относятся гамма-глутамилтран-сфераза (ГГТ), аспартат-и аланинаминотрансферазы Алкогольная кардиомиопатия (АСТ и АЛТ), средний объем эритроцита (MCV), кар-богидрат-дефицитный трансферрин (CDT) [44,45].…”

Effects of heroin-assisted treatment on alcohol consumption: findings of the German randomized controlled trial

“…CDT sample size was considerably smaller due to protocol violations (wrong laboratory units at baseline or not having completed CDT analyses in order to save costs). Furthermore, an ASI CS threshold of 0.17 for predicting alcohol dependence diagnosis has been recommended (Rikoon et al, 2006), while a cut-off of 3% is recommended for clinical relevance of CDT (Hock, 2005), both of which were used in this study.…”