Validity of Childhood Autism in the Danish Psychiatric Central Register: Findings from a Cohort Sample Born 1990–1999

Lauritsen, Marlene Briciet; Jørgensen, Meta; Madsen, Kathrine Bang; Lemcke, Sanne; Toft, Susanne; Grove, Jakob; Schendel, Diana; Thorsen, Poul

doi:10.1007/s10803-009-0818-0

Cited by 222 publications

(179 citation statements)

References 29 publications

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“…The positive predictive value of the infantile autism diagnosis found in the DCPR has been reported to be 94%. 13 The prevalence of ASD in the Danish register 14 is comparable to ASD prevalence observed in the United States 15 and a prevalence estimate for ASD observed in a screening study conducted in Denmark. 16 …”

Section: Data On Asdsupporting

confidence: 58%

Autism After Infection, Febrile Episodes, and Antibiotic Use During Pregnancy: An Exploratory Study

2012

PEDIATRICS

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OBJECTIVES-Results of animal studies suggest that maternal immune activation during pregnancy causes deficiencies in fetal neurodevelopment. Infectious disease is the most common path to maternal immune activation during pregnancy. The goal of this study was to determine the occurrence of common infections, febrile episodes, and use of antibiotics reported by the mother during pregnancy and the risk for autism spectrum disorder (ASD) and infantile autism in the offspring. METHODS-We used a population-based cohort consisting of 96 736 children aged 8 to 14 years and born from 1997 to 2003 in Denmark. Information on infection, febrile episodes, and use of antibiotics was self-reported through telephone interviews during pregnancy and early postpartum. Diagnoses of ASD and infantile autism were retrieved from the Danish Psychiatric Central Register; 976 children (1%) from the cohort were diagnosed with ASD.RESULTS-Overall, we found little evidence that various types of mild common infectious diseases or febrile episodes during pregnancy were associated with ASD/infantile autism. However, our data suggest that maternal influenza infection was associated with a twofold Copyright © 2012 by the American Academy of Pediatrics Address correspondence to Hjördís Ósk Atladóttir, Section of Epidemiology, Department of Public Health, University of Aarhus, Bartholin allé 2, 8000 Århus C, Denmark. hoa@soci.au.dk. Dr Atladóttir conceptualized and designed the study, participated in acquisition of data, participated in analysis and interpretation of data, drafted the article and revised it critically for important intellectual content, and approved the final version to be published. Dr Henriksen participated in analysis and interpretation of data, revised the article critically for important intellectual content, and approved the final version to be published. Dr Schendel participated in designing the study, participated in analysis and interpretation of data, drafted the article and revised it critically for important intellectual content, and approved the final version to be published. Dr Parner participated in designing the study and acquisition, analysis, and interpretation of data; revised the article critically for important intellectual content; and approved the final version to be published.The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. FINANCIAL DISCLOSURE:The authors have indicated they have no financial relationships relevant to this article to disclose. Results of animal studies suggest that maternal immune activation during pregnancy is associated with deviations in brain development. [2][3][4] Infectious disease is the most common path to maternal immune activation during pregnancy. Several previous studies have investigated infection during pregnancy as a part of a larger assessment of various prenatal factors. 5 These studies did not look at specific infections per se but pooled a...

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Section: Data On Asdsupporting

confidence: 58%

Autism After Infection, Febrile Episodes, and Antibiotic Use During Pregnancy: An Exploratory Study

2012

PEDIATRICS

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“…For example, the authors of a recent study from Uganda recommended that autism spectrum disorders should be included in studies of neurodevelopmental disorders in low-resource settings to obtain essential data for planning local public health responses [38]. [24,39].…”

Section: Discussionmentioning

confidence: 99%

Neighborhood deprivation and childhood autism: A nationwide study from Sweden

Sjöstedt

Sundquist

et al. 2014

Journal of Psychiatric Research

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“…However, in several studies, validation of some diagnoses (e.g. schizophrenia, single episode depression, dementia, autism), has been carried out with good results [8][9][10][11][12]. …”

Section: Validity Of Diagnosesmentioning

confidence: 99%

The Danish Psychiatric Central Research Register

Mors

Perto

Mortensen

2011

Scand J Public Health

1,386

1,302

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Introduction: The Psychiatric Central Research Register (PCRR) has continued since 1970 with electronic registration of patients treated at psychiatric departments in Denmark. Content: The register contains dates of onset and end of any treatment; all diagnoses; type of referral; place of treatment; municipality of residence; mode of admission. Validity and coverage: Systematic studies validating the clinical diagnoses do not exist. However, several studies have validated specific diagnoses. The nationwide registration of severe mental disorders is almost complete. However, most cases with mild to moderate mental disorders are diagnosed and treated by general practitioners or specialists in psychiatry working in private practice and are thus not registered in the PCRR. Conclusion: The PCRR is a valuable tool in national health planning and in epidemiological research.

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Validity of Childhood Autism in the Danish Psychiatric Central Register: Findings from a Cohort Sample Born 1990–1999

Cited by 222 publications

References 29 publications

Autism After Infection, Febrile Episodes, and Antibiotic Use During Pregnancy: An Exploratory Study

Autism After Infection, Febrile Episodes, and Antibiotic Use During Pregnancy: An Exploratory Study

Neighborhood deprivation and childhood autism: A nationwide study from Sweden

The Danish Psychiatric Central Research Register

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