ObjectiveTo identify characteristics associated with an intention to complete advance directives (ADs) and end‐of‐life treatment preferences for outpatients with heart failure (HF).MethodsA cross‐sectional, analytical study. Sociodemographic and clinical data were collected from 108 patients with HF in an outpatient clinic in São Paulo, SP, Brazil. Quality of life (QoL) was assessed using the Minnesota Living with Heart Failure Questionnaire; knowledge about HF and the intention to complete ADs were assessed using a script. The relationships among variables were assessed through the chi‐square and Mann–Whitney tests, with p < 0.05 considered significant.ResultsThe intention to complete ADs was significantly associated with reporting adherence to pharmacological recommendations (99% vs. 88.1%, p = 0.02), worse QoL (29.7 ± 18.2 vs. 20.9 ± 11.0; p = 0.0336), perceived knowledge about HF (89.7% vs. 63.6%, p = 0.0495), not wishing the healthcare providers would decide about treatment (27.3% vs. 2.15, p = 0.0026), and considering ADs useful (91.8% vs. 27.3%, p < 0.001). End‐of‐life treatment preferences included living as long as possible (50.5%), not being sedated (37.1%), and staying close to family and friends for as long as possible (32.0%).ConclusionsCharacteristics associated with an intention to complete ADs and end‐of‐life treatment preferences were identified in patients with HF.Implications for nursing practiceThese results can help facilitate patients’ completion of their ADs or activate their intention to maximize opportunities to exercise autonomy.