The main hazards in the process of manual handling work are triggered by human factors and ergonomics. This study is intended to implement a valid approach to quantitatively evaluate the risk level during manual handling work. A risk assessment model for manual handling workers was proposed based on subjective and objective correlation. A simulation experiment of manual handling process was developed and an ergonomics evaluation method was carried out. The 33‐point human joint model of BlazePose neural network and the Rapid Upper Limb Analysis (RULA) method were utilized to determine the risk posture and risk index of the manual handling workers. This study brought together hemodynamic parameters and the score of Borg Rating of Perceived Exertion (RPE) scale and Physical Resources Scale (PRS) to obtain the final comprehensive index of work risk. The results showed that the risk indexes from the three stages of the experiment obtained by RULA method were 3, 4, and 7. And the scores of comprehensive indexes obtained by the risk assessment model were 1.841, 1.900, and 1.987, suggesting that the evaluation model based on subjective and objective correlation had the same ability to determine the risk levels of different handling tasks. Therefore, the risk assessment model proposed in this study verified the effectiveness of the comprehensive evaluation index integrating hemodynamic parameters and subjective evaluation scores.