Validity of the Portuguese CHO‐KLAT in Brazil

Villaça, Paula Ribeiro; Blanchette, Victor S.; Carneiro, Jorge David Aivazoglou; Ozelo, Margareth C.; Antunes, Sandra Vallin; Feldman, B. M.; Abad, Audrey; Usuba, Koyo; Young, Nancy L.

doi:10.1111/hae.13031

Cited by 7 publications

(6 citation statements)

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“…The final Ivoirian CHO-KLAT 2.0 was moderately correlated with the PedsQL score in the child reports (Pearson's r = 0.581), which is similar to the results of the Canadian study (r = 0.59) [12] and other cross-cultural validations of the CHO-KLAT 2.0 (e.g., in Brazil (r = 0.47) [16] and China (r = 0.67) [18]). This confirms the validity of the final Ivoirian CHO-KLAT 2.0 among self-reporting BWHs.…”

Section: Relationship Between Hrqol and The Hjhssupporting

confidence: 81%

“…The CHO-KLAT has strong psychometric properties, with proven test-retest reliability [12], content validity [11], and high child-parent concordance [12]. It was initially developed in North American English and was then updated to a version 2.0 [13] and cross-culturally adapted and validated in several European countries [14], as well as China [15,16] and Brazil [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Cross-cultural adaptation and validation of the Canadian Haemophilia Outcomes-Kids’ Life Assessment Tool (CHO-KLAT) in Côte d’Ivoire (the Ivory Coast)

Lambert

Meité

Sanogo

et al. 2020

Health Qual Life Outcomes

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Introduction: Health-related quality of life evaluation is recognized as an important outcome in the assessment of boys with haemophilia. In fact, reliable health-related quality of life data are even more critical in developing countries to advocate for government agencies to develop national haemophilia care programmes. However, validated tools are not yet available in sub-Saharan African countries. Aims: The purpose of this study was to complete the cultural adaptation and validation of the Canadian Haemophilia Outcomes-Kids' Life Assessment Tool version 2.0 (CHO-KLAT 2.0) in Côte d'Ivoire. Methods: The process included four steps: a linguistic adaptation, cognitive debriefing interviews with children and their parents, a validity assessment with the Pediatric Quality of Life Inventory (PedsQL) as a comparator, and a testretest reliability assessment. Results: The initial Ivoirian version of the CHO-KLAT 2.0 was developed through a linguistic adaptation performed in close collaboration with members of the local medical team and haemophilia community. Cognitive debriefings were completed with five boys and their parents, with the final Ivoirian version of the CHO-KLAT 2.0 developed in September 2017. The validation process included 37 boys with haemophilia (mean age: 11.4 years; 34 with severe and three with moderate forms of haemophilia, all treated on demand) and their parents. Among the child-reported population (n = 20), we observed a mean CHO-KLAT 2.0 score of 51.3 ± 9.2; there was a moderate correlation between the CHO-KLAT 2.0 and PedsQL scores (r = 0.581; p = 0.007) and an inverse correlation of the CHO-KLAT 2.0 and PedsQL scores with the global rating of the degree to which the boys were bothered by their haemophilia. The mean parent proxy CHO-KLAT 2.0 score (n = 17) was 53.5 ± 9.8. Among the parents, we found no significant correlation between the Ivoirian CHO-KLAT 2.0 and PedsQL scores or between the parent-reported scores and the parent global ratings of bother. The test-retest intraclass correlation coefficient was 0.879 (95% CI: 0.673; 0.954) for the child-reported questionnaires and 0.880 (95% CI: 0.694; 0.955) for the proxy-reported questionnaires.

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Section: Relationship Between Hrqol and The Hjhssupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Cross-cultural adaptation and validation of the Canadian Haemophilia Outcomes-Kids’ Life Assessment Tool (CHO-KLAT) in Côte d’Ivoire (the Ivory Coast)

Lambert

Meité

Sanogo

et al. 2020

Health Qual Life Outcomes

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“…The Canadian Hemophilia Outcomes–Kids Life Assessment Tool (CHO‐KLAT) is a disease‐specific HRQoL instrument validated for use in boys 4‐18 years of age. It has been used in a number of clinical studies and was found to be sensitive to clinically important changes in the setting of the use of factor (F)VIII/FIX concentrates for the management of boys with hemophilia . Pooled CHO‐KLAT data from clinical studies in 9 countries provided a sample size large enough to allow evaluation of the impact of treatment on HRQoL while controlling for confounding relationships.…”

Section: Introductionmentioning

confidence: 99%

Impact of prophylaxis on health‐related quality of life of boys with hemophilia: An analysis of pooled data from 9 countries

Usuba

Price

Blanchette

et al. 2019

Research and Practice in Thrombosis and Haemostasis

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Background Prophylaxis reduces the frequency of bleeds in boys with severe hemophilia and is the standard care for their management in resource‐abundant countries. The effect of prophylaxis on Health‐Related Quality of Life (HRQoL) has not been established, because the sample sizes of most studies are too small to explore the relationship of multiple factors that influence HRQoL. Methods The aim of this study was to assess the impact of hemophilia severity and treatment regimen on HRQoL and to establish the minimum important difference (MID) using the international level of score distributions. HRQoL data were pooled from 7 studies across 9 countries. HRQoL was measured using the Canadian Hemophilia Outcomes–Kids’ Life Assessment Tool (CHO‐KLAT). A mixed‐effect linear regression analysis was employed to assess the impact of prophylaxis on the CHO‐KLAT score. Results Data from 401 boys with hemophilia were analyzed (57.6% severe hemophilia and 57.6% receiving prophylaxis). The model revealed that receiving prophylaxis was significantly associated with higher HRQoL (regression coefficient 8.5, 95% confidence interval [CI] 3.9‐13.1). Boys with severe hemophilia had a significantly lower HRQoL as compared to boys with moderate and mild hemophilia whose CHO‐KLAT scores were 7.0 and 6.6 points higher, respectively. There was a significant interaction between treatment and disease severity (P = 0.023), indicating prophylaxis has the most significant impact in boys with severe hemophilia. Based on these pooled data, the MID of the CHO‐KLAT was established at 6.5. Conclusions This study confirms the positive effect of prophylaxis on HRQoL in boys with hemophilia in a real‐world setting and provides initial benchmarks for interpreting HRQoL scores based on use of the CHO‐KLAT instrument.

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“…No Brasil, foram realizadas na população-alvo a pesquisa de tradução do instrumento para o português, a verificação da aplicabilidade cultural e as entrevistas cognitivas (debriefings) 16 , que consistiram em um processo interativo no qual um questionário é administrado aos participantes, usando uma abordagem de entrevista face a face 27,28 , bem como a validação do instrumento para o português 17 . Na versão em português do Brasil, o CHO-KLAT2.0 apresentou alterações em 23 (66%) dos itens.…”

Section: Introductionunclassified

“…Participaram do estudo 50 meninos, com idade entre 7,3 e 18 anos, e o escore total médio do instrumento CHO-KLAT foi de 72,3 e do PedsQL foi de 79,9, com correlação positiva entre os dois instrumentos (r=0,47, p<0,001). Portanto, o instrumento CHO-KLAT versão brasileira pode ser utilizado para pesquisas em crianças e adolescentes com hemofilia no Brasil 17 .…”

Section: Introductionunclassified

Qualidade de vida avaliada pelo instrumento “Canadian Haemophilia Outcomes: Kids' Life Assessment Tool”: uma revisão

Borato¹,

Vellosa²,

Pedroso³

et al. 2017

Conexão Ci.

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ResumoIntrodução: A hemofilia tem um impacto significativo sobre a Qualidade de Vida Relacionada à Saúde. Dessa forma, instrumentos para avaliação da qualidade de vida podem ser uma forma de verificar o impacto de graves complicações da doença sobre a vida dos pacientes. Instrumentos específicos para crianças e adolescentes são escassos, destacando-se o Canadian Haemophilia Outcomes Kids Life Assessment Tool (CHO-KLAT). Objetivo: Realizar uma revisão de literatura sobre a utilização do instrumento CHO-KLAT, considerando o histórico da adaptação transcultural e validação e as vantagens e desvantagens de sua utilização. Metodologia: Foram consultados os portais de periódicos Medline, Lilacs, Scopus e SciELO, entre o período de 2004 a 2016, com os seguintes descritores: "qualidade de vida" e "avaliação" ou "instrumento" e "hemofilia" e "Canadian Haemophilia Outcomes: Kids' Life Assessment Tool" ou "CHO-KLAT", em português, espanhol e inglês. Resultados: Foram selecionados 15 artigos para leitura na íntegra e avaliação. Os resultados demonstraram que a maioria dos estudos (60,0%) que utilizaram o instrumento CHO-KLAT foram realizados no Canadá. Com relação à adaptação transcultural e/ou validação, foram encontrados seis artigos. Além disso, três publicações realizaram uma análise crítica do instrumento, duas aplicaram o instrumento CHO-KLAT e um artigo apresentou uma revisão sistemática. Conclusão: Observa-se uma escassa literatura sobre esse instrumento. Portanto, espera-se que os resultados obtidos contribuam para futuros trabalhos relacionados à aplicação de instrumentos específicos de avaliação da qualidade de vida em crianças e adolescentes com hemofilia, especialmente o CHO-KLAT.Palavras-chave: qualidade de vida, hemofilia, questionários, crianças, adolescentes, revisão de literatura. Assim, a avaliação da QVRS torna-se importante em diversas doenças, como a hemofilia, um distúrbio hemorrágico hereditário ligado ao cromossomo X, caracterizada pela deficiência ou anormalidade no processo de coagulação sanguínea, classificada como hemofilia A (deficiência do fator VIII) ou hemofilia B (deficiência do fator IX) 2 . Qualidade de vida avaliada pelo instrumento "CanadianA hemofilia tem um impacto significativo na qualidade de vida (QV) dos indivíduos que apresentam essa patologia, uma vez que podem apresentar episódios repetidos de hemorragias em articulações, músculos e tecidos moles 3 . A principal expressão clínica da hemofilia é evidenciada pela hemartrose, com as primeiras manifestações entre um e cinco anos, caracterizada por sangramentos articulares, principalmente em tornozelos, joelhos e cotovelos 4 . Os sangramentos repetidos podem causar danos permanentes nas articulações e tecidos moles, com dor associada e limitações na função física, resultando em diminuição da QV 3 .Outro problema relacionado à QV de indivíduos com hemofilia consiste em determinados aspectos com relação ao tratamento, como a realização de profilaxia com reposição de fator, que ocorre, geralmente, duas ou três vezes por semana para evi...

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Validity of the Portuguese CHO‐KLAT in Brazil

Abstract: The results confirm the validity of the Portuguese version of the CHO-KLAT. This measure is now available for clinical trials in boys with haemophilia in Brazil.

Cited by 7 publications

References 17 publications

Cross-cultural adaptation and validation of the Canadian Haemophilia Outcomes-Kids’ Life Assessment Tool (CHO-KLAT) in Côte d’Ivoire (the Ivory Coast)

Cross-cultural adaptation and validation of the Canadian Haemophilia Outcomes-Kids’ Life Assessment Tool (CHO-KLAT) in Côte d’Ivoire (the Ivory Coast)

Impact of prophylaxis on health‐related quality of life of boys with hemophilia: An analysis of pooled data from 9 countries

Qualidade de vida avaliada pelo instrumento “Canadian Haemophilia Outcomes: Kids' Life Assessment Tool”: uma revisão

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