Validity of triglyceride–glucose index as an indicator for metabolic syndrome in children and adolescents: the CASPIAN-V study

Angoorani, Pooneh; Heshmat, Ramin; Ejtahed, Hanieh‐Sadat; Motlagh, Mohammad Esmaeil; Ziaodini, Hasan; Taheri, Majzoubeh; Aminaee, Tahereh; Goodarzi, Azam; Qorbani, Mostafa; Kelishadi, Roya

doi:10.1007/s40519-018-0488-z

Cited by 69 publications

(58 citation statements)

References 34 publications

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“…Limited data are reported in pediatric age, in which the TyG index has been described as a useful predictor of metabolic abnormalities in Asian, Mexican American, Non-Hispanic White adolescents (15)(16)(17)(18)(19)(20)(21). Untill now there is no consensus for reference criteria in Caucasian children, besides no pediatric study has been conducted on this topic.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

“…A study carried out with Korean adolescents aged 10-18 identified cutoff points between 8.41 and 8.66 for TyG index to predict metabolic syndrome, using different diagnostic criteria (18). Angoorani et al (19) The present study in Caucasian subjects identified an optimal cut-off of 7.98 for IR, that may be used for assessing IR and associated metabolic risk in children and teenagers with overweight and obesity, although caution is required when applied to other populations metabolically at risk. A study limitation that should be acknowledged is the lack of dietary data.…”

Section: Correlation Between Tyg and Homa-irmentioning

confidence: 99%

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Triglyceride Glucose Index as a Surrogate Measure of Insulin Sensitivity in a Caucasian Pediatric Population

Calcaterra¹,

Montalbano²,

Silvestri³

et al. 2024

Jcrpe

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The triglyceride and glucose (TyG) index has been proposed as a simple surrogate of insulin resistance (IR) with high sensitivity as an IR index besides the well known homeostasis model assessment of IR (HOMA-IR). Limited data are reported in children. We investigated the sensitivity and specificity of TyG index in a pediatric Caucasian population, as a surrogate measure of IR and compared the results with HOMA-IR. Methods: We enrolled 541 children (11.7±2.71 yrs). According to body mass index (BMI) chart, the subjects were divided into three groups: normal weight BMI<75th percentile, overweight BMI 75th-95th percentile, and obese>95 th percentile. TyG index was calculated as (ln[fasting triglycerides(mg/dl)×fasting plasma glucose(mg/dl)/2]) and considered pathological when exceeding 7.88. HOMA-IR was calculated as (insulin×glucose)/22.5 and defined pathological whenever exceeding 97.5th percentile for age and sex. Results: In children with overweight/obesity TyG index was higher compared to normal weight subjects (p<0.001). TyG index was correlated with BMI (p<0.001); WHtR (p<0.001), total and HDL cholesterol (p<0.001); ALT (p<0.001), blood pressure (p<0.001). A correlation between TyG index and HOMAIR (p<0.001) as well as high TyG index and pathological HOMA-IR (p<0.001) were noted. The optimal cutoff for IR was considered 7.98 (sensitivity 60%; specificity 78%; AUC 0.69). Conclusions: TyG index is a useful and cost-effective index of IR among children and adolescents. The cutoff 7.98 may be used for IR risk screening in childhood obesity, but we recommend caution when used in other populations.

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Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

Section: Correlation Between Tyg and Homa-irmentioning

confidence: 99%

Triglyceride Glucose Index as a Surrogate Measure of Insulin Sensitivity in a Caucasian Pediatric Population

Calcaterra¹,

Montalbano²,

Silvestri³

et al. 2024

Jcrpe

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“…TyG index showed better performance for assessing IR than the homeostasis model assessment of IR(HOMA-IR) [7,8]. A number of studies have found a positive association between TyG index and cardiovascular risk, including systematic CAD, carotid atherosclerosis, hypertension, metabolic syndrome, arterial stiffness and coronary calcification [9][10][11][12][13][14][15]. Furthermore, recent data suggest that TyG index could provide significant prognostic information in patients with established CAD [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome

Wang

Cong

Zhang

et al. 2020

Preprint

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Background: Triglyceride-glucose index (TyG index) has been regarded as a reliable alternative marker of insulin resistance and an independent predictor of cardiovascular outcomes. Whether TyG index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome (ACS) remains uncertain. The aim of the present study was to investigate the prognostic value of TyG index in patients with diabetes and ACS.Methods: A total of 2531 consecutive patients with diabetes who underwent coronary angiography for ACS were enrolled in the study. Patients were divided into 3 tertiles according to TyG index. The primary outcomes included the occurrence of major adverse cardiovascular events (MACE), defined as all-cause death, non-fatal myocardial infarction and non-fatal stroke. The TyG index was calculated as ln (fasting triglyceride level (mg/dL) ×fasting glucose level (mg/dL)/2).Results: The incidence of MACE increased with TyG index tertiles after 3-year follow-up. Kaplan-Meier curves showed significant differences in event-free survival rates among TyG index tertiles (P=0.005).Multivariate Cox hazards regression analysis revealed that TyG index was an independent predictor of MACE (95% CI 1.201-1.746; P<0.001). The optimal TyG index cut-off for predicting MACE was 9.323 (sensitivity 46.0% ; specificity 63.6%; area under the curve 0.560; P=0.001 ).Furthermore, adding TyG index to the prognostic model for MACE improved the C-statistic value (P=0.010), the integrated discrimination improvement value(P=0.001) and the net reclassification improvement value(P=0.019).Conclusions TyG index predicts future recurrent cardiovascular events in patients with diabetes and ACS, independently of known cardiovascular risk factors suggesting that TyG index may be a useful marker for risk stratification and prognosis in patients with diabetes and ACS.

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“…У взрослых верхняя граница по данным зарубежной литературы составляет 8,8 [14]. По данным испанского исследования Gesteiro E., et al (2018), верхняя граница у новорожденных составляет 7,8 [15], а по результатам крупного иранского исследования точка отсечения у детей в возрасте от 7-18 лет -8,33 [16]. По нашим данным, индекс не выходил за рамки ориентировочно нормальных, но, тем не менее, необходимы крупномасштабные исследования на детской популяции с целью определения нормальных значений индекса в соответствии с возрастными периодами.…”

Section: обсуждение основного результата исследованияunclassified

The relationship of eating behavior with biochemical blood parameters in children and adolescents born preterm

et al. 2019

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BACKGROUND: Prematurity is a risk for the formation of adverse metabolic disorders, the components of which can progress and lead to obesity. However, at the moment, the presence and nature of interrelations of metabolic parameters with the type of nutrition have not been established, there is also no clear idea of the age and structure of the initial manifestations of metabolic shifts, the prevalence of eating disorders in children born prematurely. AIMS: To determine the frequency and structure of the initial manifestations of the metabolic syndrome (abdominal obesity, impaired glucose tolerance, dyslipidemia, hypertension); to establish associations of types of eating behavior with biochemical parameters characterizing the adverse metabolic phenotype in children and adolescents born prematurely. MATERIALS AND METHODS: The study involved 123 children: in the main group (group 1) there were children and adolescents aged 10-17 years 11 months who were born prematurely (less than 37 weeks at birth and less than 2500 grams at birth), in the control group (group 2) included full-term children (more than 37 weeks and more than 2500 grams at birth). The study included clinical anthropometry with measurement of body weight, height, waist circumference (WC) and hips (HC), followed by calculation of body mass index (BMI) and ratio of WC/HC, measurement of blood pressure (BP). Eating behavior (EB) was assessed using a modified validated Dutch Eating Behavior Questionnaire (DEBQ). RESULTS: WC equal to or above the 90th percentile were only in children from the main group (4 children (9.7%).There were not observed such parameters in the control group (=4.63, p=0.047). BP higher than the 95th percentile was observed mainly in children born prematurely: 19 children (46.3%) against one (3.3%) of the control group (=21.94, p 0.001). Eating disorders are often found in both groups (59 of 123 (47.9%)): the control group had 35 of 65 (53.8%) children against 24 of 58 (41.4%) of the main group (p0.05). CONCLUSIONS: The components of metabolic syndrome are registered more often in children born prematurely. Eating disorders are often found in both groups.

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Validity of triglyceride–glucose index as an indicator for metabolic syndrome in children and adolescents: the CASPIAN-V study

Abstract: Level V, cross-sectional descriptive study (National surveillance study).

Cited by 69 publications

References 34 publications

Triglyceride Glucose Index as a Surrogate Measure of Insulin Sensitivity in a Caucasian Pediatric Population

Triglyceride Glucose Index as a Surrogate Measure of Insulin Sensitivity in a Caucasian Pediatric Population

Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome

The relationship of eating behavior with biochemical blood parameters in children and adolescents born preterm

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