Validity of using a relative potency factor approach for the risk management of dioxin-like polychlorinated naphthalenes

Suzuki, Go; Michinaka, Chieko; Matsukami, Hidenori; Noma, Yukio; Kajiwara, Natsuko

doi:10.1016/j.chemosphere.2019.125448

Cited by 29 publications

(13 citation statements)

References 25 publications

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“…Earlier studies reported that the presence of PCNs in environmental compartments is associated with impurities in technical mixtures of PCNs and polychlorinated biphenyls (PCBs) and the combustion processes of waste incinerators and metal plating manufacturing (Wang et As dioxin-like contaminants that can cause adverse health effects by binding with aryl hydrocarbon (AhR) receptors, toxicities of PCNs are similar to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and PCBs (Falandysz et al, 2014). Laboratory animal studies have found that PCN congeners elicit neurotoxicity, carcinogenicity, genotoxicity, and reproductive and developmental toxicities (Behnisch et al, 2003;Falandysz et al, 2014;Suzuki et al, 2020). Ecotoxicological data on PCNs have been also reported for several species at different trophic levels, including algae, aquatic plants, invertebrates, sh, and birds (Noma et al, 2005;Gu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Spatial and temporal trends in polychlorinated naphthalenes in sediment from industrialized coastal environments of Korea: Potential sources and ecotoxicological concerns

Lee

Lee³

et al. 2022

Preprint

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Few studies have been conducted on spatial and temporal trends in polychlorinated naphthalenes (PCNs) in coastal environments. Here, we describe 18 PCN congeners found in surface and dated sediment samples collected from highly industrialized bays of Korea. Measurable levels of PCN congeners were detected in all sediment samples, suggesting concurrent and historical contamination. The highest PCN concentrations were observed in sediment from rivers, streams, and the inner portions of the bays, which are surrounded by industrial complexes and commercial harbours. CNs 73, 66/67, and 52 were dominant in surface and dated sediment samples. Congener patterns and diagnostic ratios revealed that PCN contamination is originated from combustion processes and the use of polychlorinated biphenyl (PCB) technical mixtures. PCN concentrations in dated sediment increased from the 1980s to the mid 2000s and then decreased to 2015. Although the toxic equivalent (TEQ) levels of PCNs in our study did not exceed sediment quality guidelines proposed by international authorities, the cumulative risks from the TEQ concentrations of polychlorinated dibenzo-p-dioxins, furans, PCBs, and PCNs can be expected for benthic organisms.

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Section: Introductionmentioning

confidence: 99%

Spatial and temporal trends in polychlorinated naphthalenes in sediment from industrialized coastal environments of Korea: Potential sources and ecotoxicological concerns

Lee

Lee³

et al. 2022

Preprint

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“…The structural similarity of PCNs to the highly toxic 2,3,7,8-tetrachlorodibenzo-p-dioxin (2378-TCDD) indicates an aryl hydrocarbon receptor-mediated mechanism of toxicity (dioxin-like toxicity). Among PCNs, 1,2,3,6,7,8-hexachlorinated naphthalene showed the highest toxicity, and its relative potency has been detected by a CALUX test as 0.0051 compared to 2378-TCDD [7][8][9]. This relative toxicity value corresponds to the third highest for the Co-PCB in the WHO's 2005 reevaluation of toxic equivalency factors (TEFs) for dioxins and dioxin-like compounds [9]; therefore, the behaviors, toxicity, and removal of PCNs in aquatic environments should be investigated.…”

Section: Introductionmentioning

confidence: 99%

Determination of Polychlorinated Naphthalenes in Landfill Leachates and its Removal in Wastewater Treatment Processes

Ito

Kameoka

Ono

et al. 2021

J. of Wat. & Envir. Tech.

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Di-through octachlorinated naphthalenes (DiCNs, TrCNs, TeCNs, PeCNs, HxCNs, HpCNs and OcCN) in landfill leachates can be analyzed with the same cleanup procedure as dioxins. In this study, a modified method was developed by confirming the elution order of each isomer of polychlorinated naphthalenes (PCNs) in a chromatogram of a gas chromatograph/high resolution mass spectrometer (GC/HRMS) using an Rh-12 ms capillary column, which is mainly employed for the analysis of dioxins. Using this method, PCNs in landfill leachate samples and treated leachate samples from each corresponding wastewater treatment process were quantified. PCN concentrations in landfill leachates ranged from 8.0-12,000 pg/L, and DiCNs-PeCNs were detected in almost all samples. Removal of PCNs by flocculation and active carbon treatment was greater than that achieved by activated sludge treatment in wastewater treatment plants. Furthermore, by changing the temperature of the H 2 SO 4 coated silica gel column in the modified method, it became possible to measure monochlorinated naphthalenes (MoCNs), which could not be measured previously. MoCN concentrations detected were much higher compared to concentrations of DiCNs-OcCN in most of landfill leachates. Unlike PCNs, MoCNs are not POPs, but they are nevertheless important for understanding the properties of landfill leachates.

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“…Based on the structural similarities with polychlorinated biphenyls (PCBs) and polychlorinated dibenzop-dioxins and dibenzofurans (PCDD/Fs), PCNs showed similar dioxin-like toxicological effects binding with aryl-hydrocarbon (AhR) receptors (Falandysz et al, 2014). Previous in vivo and in vitro studies have reported that PCNs elicited mortality, embryotoxicity, hepatotoxicity, dermal lesions, teratogenicity, and carcinogenicity (Behnisch et al, 2003;Falandysz et al, 2014;Suzuki et al, 2020). The ecotoxicological data of PCNs have been reported for several species representing different trophic levels: algae, aquatic plants, invertebrates, fish, and birds (Noma et al, 2005;Helm et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Due to the enhanced sensitivity, chromatograph coupled to a tandem mass spectrometer (GC-MS/MS) has been partly utilized for PCN analysis in sediment samples (Li et al, 2016a;Wu et al, 2018). The challenge for an analytical method using a GC-MS/MS is the separation of individual PCN congeners because PCNs showed congener-specific toxicities (Falandysz et al, 2014;Suzuki et al, 2020). In our study, the analytical methods were optimized using a multi-layer silica gel column and a GC-MS/MS for the determination of major PCN congeners in sediment samples.…”

Section: Introductionmentioning

confidence: 99%

Distribution of Polychlorinated Naphthalenes in Sediment From Industrialized Coastal Waters of Korea With the Optimized Cleanup and GC-MS/MS Methods

Lee

Lee³

et al. 2021

Front. Mar. Sci.

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Limited studies have been conducted on polychlorinated naphthalenes (PCNs) in the coastal environment worldwide. In this study, analytical methods were optimized for 18 PCN congeners in sediment using a multi-layer silica gel column and a gas chromatograph coupled to tandem mass spectrometry (GC-MS/MS). The optimized analytical methods of PCNs were employed for sediment samples from heavily industrialized bays of Korea to assess the occurrence, contamination, potential sources, and ecotoxicological concerns. PCNs were detected in all sediment samples, indicating ubiquitous contamination in industrialized coastal regions of Korea. Total concentrations and toxic equivalents (TEQs) of PCNs ranged from 0.99 to 21,500 (mean: 568) pg/g dry weight and from 1.72 × 10–5 to 18.8 (mean: 0.52) pg TEQ/g dry weight, respectively, which were within the ranges reported by other studies. A clear decreasing gradient was observed for the sedimentary PCNs from inner to outer parts of the bays, streams, and rivers. This result indicates that industrial activities are primary sources of PCNs. The highest PCN concentrations were observed in sediment close to non-ferrous and petrochemical industries, indicating potential sources. CNs 73 and 52 were predominant congeners of PCNs in all sediment samples. Diagnostic ratios and non-parametric multidimensional scaling analysis showed that the potential primary sources of PCNs are thermal-related emissions and the use of PCB technical mixtures. Although a few sediment samples exceeded the sediment quality guidelines of TEQs, the cumulative risks by dioxin-like contaminants may be caused for almost all coastal zones surveyed. This is the first report on PCNs in sediment from Korean coastal waters.

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Validity of using a relative potency factor approach for the risk management of dioxin-like polychlorinated naphthalenes

Cited by 29 publications

References 25 publications

Spatial and temporal trends in polychlorinated naphthalenes in sediment from industrialized coastal environments of Korea: Potential sources and ecotoxicological concerns

Spatial and temporal trends in polychlorinated naphthalenes in sediment from industrialized coastal environments of Korea: Potential sources and ecotoxicological concerns

Determination of Polychlorinated Naphthalenes in Landfill Leachates and its Removal in Wastewater Treatment Processes

Distribution of Polychlorinated Naphthalenes in Sediment From Industrialized Coastal Waters of Korea With the Optimized Cleanup and GC-MS/MS Methods

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