Valor De Uso, Indicações Terapêuticas E Perfil Farmacológico E Etnofarmacológico De Duas Espécies Do Gênero Piper L. Em Uma Comunidade Quilombola Na Amazônia Oriental Brasileira

Pereira, Luciano Araújo; Santos, Darlan Coutinho dos; Rodrigues, Plúcia Franciane Ataíde; Andrade, Eloísa Helena de Aguiar; Guimarães, Elsie Franklin

doi:10.35587/brj.ed.0000719

Cited by 6 publications

(3 citation statements)

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“…However, an important fact to be considered in future studies with the three Euterpe species is the possibility of using other organs besides the fruit, since traditional Amazonian populations use organs such as the root and seed of EP and EO in folk medicine to treat clinical conditions including malaria [83,84], urinary tract infection, diarrhea, intestinal infection [85][86][87], verminosis [88], hemorrhoids, and varicose veins [89]. Data from these ethnopharmacological studies are strengthened by other scientific studies showing that EO seeds are rich in proanthocyanidins, compounds with several beneficial effects, including anti-inflammatory and antioxidant actions.…”

Section: Experimental Models To Study Neuroprotectionmentioning

confidence: 99%

What We Know about Euterpe Genus and Neuroprotection: A Scoping Review

Da Silva,

Crespo-Lopez,

Augusto-Oliveira

et al. 2023

Nutrients

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The Euterpe genus (mainly Euterpe oleracea Martius, Euterpe precatoria Martius, and Euterpe edulis Martius) has recently gained commercial and scientific notoriety due to the high nutritional value of its fruits, which are rich in polyphenols (phenolic acids and anthocyanins) and have potent antioxidant activity. These characteristics have contributed to the increased number of neuropharmacological evaluations of the three species over the last 10 years, especially açaí of the species Euterpe oleracea Martius. The fruits of the three species exert neuroprotective effects through the modulation of inflammatory and oxidative pathways and other mechanisms, including the inhibition of the mTOR pathway and protection of the blood–brain barrier, all of them intimately involved in several neuropathologies. Thus, a better understanding of the neuropharmacological properties of these three species may open new paths for the development of therapeutic tools aimed at preventing and treating a variety of neurological conditions.

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Section: Experimental Models To Study Neuroprotectionmentioning

confidence: 99%

What We Know about Euterpe Genus and Neuroprotection: A Scoping Review

Da Silva,

Crespo-Lopez,

Augusto-Oliveira

et al. 2023

Nutrients

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“…Piper marginatum Jacq., called "malvarisco" or "caapeba cheirosa" in Amazonas State, Brazil, has been cited as sedative and anti-inflammatory in the treatment of snake bites (D'Angelo et al 1997;Guimarães & Giordano, 2004). In a recent study, Pereira et al (2020) indicated its use against erysipelas, urinary and dermatological infections, among others. The present study gives a contribution to enhance the knowledge about the composition and demonstrates evidence of antimicrobial effects of essential oils from P. marginatum by screening six different pathogenic bacteria growing in suspension and adhered to polystyrene microplates.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and antibiofilm properties of essential oils from Piper marginatum Jacq.

Santos

Araújo

Matisui

et al. 2021

RSD

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A low shrub growing in the Amazonian region, Piper marginatum Jacq. has been related to the treatment of a disease variety in folk medicine, however, still lacking scientific support. This study aimed to describe the composition of essential oils obtained from leaves (EOL) and branches (EOB) of P. marginatum and their antimicrobial effects on six relevant pathogenic bacteria. A combination of GC-FID and GC-MS was used to identify the phytochemical constituents. As antimicrobial assays, the oils were screened at the minimum inhibitory concentration (MIC) of 3 µg/ml for planktonic and biofilm inhibition. EOL revealed the presence of trans–nerolidol, o–cymene, spathulenol, elemicin, and α–copaene, while EOB composition was mainly of myristicin, trans-caryophyllene, trans-nerolidol, caryophyllene oxide, α–copaene, γ–muurolene and spathulenol. The strongest inhibition of planktonic growth was achieved against Pseudomonas aeruginosa (EOB) and Escherichia coli (EOB). Overall, Gram negative bacteria were more sensitive to both EOB/EOL showing less ability of growth and biofilm formation. The Gram-positive strains seemed to react to the essential oils by massive adhesion. Our results corroborate the relevance of Piperaceae and indicate the possible use of P. marginatum in future developments of antimicrobials.

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“…Os principais compostos detectados foram β-copaen-4-α-ol (26%), 7-epi-α-eudesmol (21,84%), epiα-cadinol (12,70%) e n-hexil-benzoato(12,29%). A atividade atinfúgica também tem sido relatada em outras espécies de Piper22 . Neste trabalho foi observada atividade antifúngica para CA10231 com CIM 50 na concentração de 1.000 µg/mL.Com fundamento nos estudos citados, infere-se a presença de atividade antimicrobiana de largo espectro do OEPA.…”

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