Valor del Ratio Neutrófilo-Linfocito, Ratio Plaqueta-Linfocito y Proteína C Reactiva del primer día como predictores de complicaciones postoperatorias tras cirugía oncológica gástrica

Ortiz-López, D.; Acosta-Mérida, María Asunción; Casimiro-Pérez, J.A.; Silvestre-Rodríguez, José; Marchena‐Gómez, Joaquín

doi:10.1016/j.rgmx.2020.10.003

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…The sensitivity of erythrocytes and lymphocytes to oxidative stress and reduction in their lifespan increase following deltamethrin exposure resulting in increasing the monocytes and MLR values and decreasing the lymphocytes in inflammation cases. The ratios of neutrophil, monocyte, and platelet to lymphocyte, monocyte to high-density lipoprotein, and neutrophil to lymphocyte platelet are commonly used as predictive markers of inflammatory status (Elhosary and Abdelbar, 2018; Fois et al, 2020; Jeong and Sun, 2020; Kanbay et al, 2014; Mu et al, 2021; Ortiz-López et al, 2022; Wang et al, 2019; Zhou et al, 2016). Therefore, the present findings suggest to use AISI and SIRI ratios as a prognostic factor for deltamethrin poisoning.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats

Elbanna,

Osman,

Salama

2023

Toxicol Ind Health

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Deltamethrin is one of the most effective pyrethroid compounds, widely employed in veterinary medicine, public health, and farming. Deltamethrin-triggered oxidative stress largely causes serious harm to an organism. Acute toxicity of this compound was extensively investigated, while less information is available on its oral sub-acute effects. This study assessed, in the male Albino rats, the effects of oral gavage of either 0.874 mg/kg (0.01 LD50) or 8.740 mg/kg (0.10 LD50) of deltamethrin for successive 14 days to investigate its effects on biomarkers and to detect the tissue injury in rats following subacute deltamethrin treatment. It was found that levels of glutathione peroxidase, superoxide dismutase, and catalase in the brain, kidney, and liver, alkaline phosphatase (ALP), and uric acid in serum, hematocrit, mean corpuscular volume (MCV), white blood cells (WBC)s, eosinophils, and basophils were significantly reduced compared with untreated rats. However, when rats were treated with deltamethrin for successive 14 days, alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activities in serum and the levels of thiobarbituric acid reactive substances (TBARs) in brain, kidney, and liver, red blood cell distribution width (RDW-CV), total protein, monocytes, and basophils and the ratios of neutrophils to lymphocytes, an aggregated marker of systemic inflammation and systemic immune inflammation indexes, significantly increased compared with the control group. Histologic lesions were observed in the liver, kidney, brain, testis, and epidemies in rats exposed to subacute deltamethrin for 14 days, and most tissues of rats treated with 0.10 LD50 of deltamethrin were more affected than those treated with 0.01 LD50. These findings strongly suggest that subacute exposure to deltamethrin caused significant systemic toxicity through oxidative stress resulting in biochemical and histological changes in the studied tissues. These findings highlight the potential harmful effects of deltamethrin and emphasize the importance of understanding the subacute effects of this compound, particularly in the context of veterinary medicine, public health, and farming.

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Section: Discussionmentioning

confidence: 99%

Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats

Elbanna,

Osman,

Salama

2023

Toxicol Ind Health

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“…Pesticides may trigger an abnormal inflammatory response via interference with normal physiology and the metabolic state of immune cells (Block and Hong 2005;Kumar et al 2014). In consideration of these, several inflammation and immune-based prognostic scores have been used for the recurrence of inflammatory processes and the prognosis of acute toxicity, such as neutrophil-tolymphocyte ratio (NLR) (Dundar et al 2014;Zhou et al 2016;Cao et al 2019;Jeong and Sun 2020;Lionte et al 2021;Mu et al 2021), monocyte-to-lymphocyte ratio (MLR) (Lionte et al 2021), platelet-to-lymphocyte ratio (PLR) (Elhosary and Abdelbar 2018;Wang et al 2019;Lionte et al 2021;Ortiz-López et al 2022), monocyteto-high-density lipoprotein ratio (MHR), and neutrophilto-lymphocyte platelet ratio (NLPR) (Kanbay et al 2014;Fois et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Hematological indices as indicators of inflammation induced by exposure to pesticides

Ruíz-Arias

Medina-Díaz

Bernal-Hernández

et al. 2022

Environ Sci Pollut Res

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Pesticide toxicity, both acute and chronic, is a global public health concern. Pesticides are involved in abnormal inflammatory responses by interfering with the normal physiology and metabolic status of cells. In this regard, inflammatory indices aggregate index of systemic inflammation (AISI), monocyte-to-high-density lipoprotein ratio, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte platelet ratio (NLPR), neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune inflammation index, and systemic inflammation response index (SIRI) have been used as predictive markers of inflammatory status in several diseases and also in acute poisoning events. This study aimed to determine systemic inflammation indices and their relationship with pesticide exposure from urban sprayers in 302 individuals categorized into three groups (reference group and moderate and high exposure groups). The data suggest that the AISI, MLR, NLPR, and SIRI indices were significantly higher in the exposed groups compared with the reference group. In conclusion, this study proposes that inflammation indices warrant further attention in order to assess their value as early biomarkers of acute and chronic pesticide intoxication.

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The Sub‐Acute Potential Risk of Oxamyl in Male Albino Rats

Salama,

Osman,

Elbanna

2024

Environmental Toxicology

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The current study aimed to investigate the sub‐acute effects of oxamyl on male Albino rats following oral administration of either 0.031 or 0.31 mg/kg/day for 14 consecutive days. The findings demonstrated that oxamyl produced a significant impact on most of the examined blood profile and biomarkers, along with a significant progressive and discernible alterations in the histology of organs. According to the results obtained, the potential mechanisms by which oxamyl causes its toxic effects on rats are identified as the inflammation indices, the inhibition of transaminases, alkaline phosphatase, and antioxidant enzymes, as well as the production of thiobarbituric acid reactive substances (TBARs) in organs following oxamyl treatment based on histopathological examinations. Due to the substantial genetic similarities between rats and humans, it is therefore anticipated that oxamyl will have comparable detrimental effects on humans.

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Valor del Ratio Neutrófilo-Linfocito, Ratio Plaqueta-Linfocito y Proteína C Reactiva del primer día como predictores de complicaciones postoperatorias tras cirugía oncológica gástrica

Cited by 6 publications

References 24 publications

Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats

Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats

Hematological indices as indicators of inflammation induced by exposure to pesticides

The Sub‐Acute Potential Risk of Oxamyl in Male Albino Rats

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