Valor pronóstico de la interleucina 6 en la mortalidad de pacientes con sepsis

Beneyto, Luis Alberto Pallás; Luis, Olga Rodríguez; Sánchez, Carmen Sáiz; Simón, Oscar Coltell; Rentero, Daniel Bautista; Bayarri, Vicente Miguel

doi:10.1016/j.medcli.2016.06.001

Cited by 13 publications

(4 citation statements)

References 23 publications

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“…Numerous studies demonstrated an increase in IL-6 circulating levels in the severe forms of sepsis and septic shock, and provided evidence of their association with sepsis mortality (37,38). In our study, the identification of statistically significant elevated plasma levels of IL-6 in septic shock compared to organ dysfunction-free septic patients was consistent with recent studies supporting its role of potential early prognostic biomarker due to its upregulated levels in sepsis, particularly in septic shock (6).…”

Section: Discussionsupporting

confidence: 91%

IL-6 gene polymorphisms and sepsis in icu adult romanian patients: a prospective study

Georgescu

Bănescu

Badea

et al. 2017

Revista Romana De Medicina De Laborator

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Objectives: The goal of the study was to investigate the correlations between the interleukin-6 IL-6 -174 G/C and IL-6 -572 G/C gene polymorphisms and sepsis risk and severity in adult ICU patients. Materials and Methods: We prospectively assessed 107 septic patients and divided them into two subgroups: organ dysfunction-free sepsis subgroup S (n=60) and septic shock subgroup SS (n=47). A control group of 96 healthy individuals was included. Both patients and controls underwent

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Section: Discussionsupporting

confidence: 91%

IL-6 gene polymorphisms and sepsis in icu adult romanian patients: a prospective study

Georgescu

Bănescu

Badea

et al. 2017

Revista Romana De Medicina De Laborator

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“…In a small prospective study, Jekarl et al reported that survivors of sepsis showed a rapid IL-6 reduction, while non-survivors showed persistently high IL-6 concentrations [11]. These findings could be confirmed by Oda et al [17] and Pallás Beneyto et al [18]. In another investigation in 24 patients with severe sepsis, survivors showed lower IL-6 levels, but no differences in IL-6 decline compared with non-survivors [19].…”

Section: Discussionmentioning

confidence: 85%

Is Interleukin-6 a better predictor of successful antibiotic therapy than procalcitonin and C-reactive protein? A single center study in critically ill adults

Weidhase

Wellhöfer

Schulze³

et al. 2019

BMC Infect Dis

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Background The aim of this study was to evaluate whether Interleukin-6 (IL-6) could be a faster indicator of treatment success in adults with severe sepsis and septic shock compared to procalcitonin (PCT) and C-reactive protein (CRP). Methods Data from adult patients with severe sepsis and septic shock managed at the medical intensive care unit (ICU) of the University Hospital Leipzig between September 2009 and January 2012 were analyzed retrospectively. Values for CRP, PCT and IL-6 on admission as well as after 24 and 48–72 h were collected. Antibiotic therapy was defined as clinically successful if the patient survived ICU stay. Results A total of 328 patients with severe sepsis and septic shock with adequate data quality were included. After 48–72 h, the median IL-6 was significantly lower in survivors than in non-survivors (114.2 pg/ml vs. 746.6 pg/ml; p < 0.001), while there was no significant difference for PCT (5.6 vs. 4.9 ng/ml; p = 0.586) and CRP (158.5 mg/l vs. 172.4 mg/l; p = 0.988). Conclusions The results of this study suggest that IL-6 is better than PCT and CRP in predicting the treatment success in predominantly non-surgical sepsis in the first 48–72 h.

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“…Unlike CRP, IL-6 can also help to distinguish infection from fever of unknown origin in pediatric practice [53]. Several studies confirm a predictive value of IL-6 for mortality and organ dysfunction in sepsis or after major trauma [54,55]. While IL-6 has undoubted prognostic value in early inflammation, clinical use has not seen any breakthroughs.…”

Section: Cytokinesmentioning

confidence: 99%

Cytokines in Inflammatory Disease

Kany

Vollrath

Relja

2019

IJMS

1,361

773

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This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines. Numerous studies have implicated that inflammatory cytokines exert important effects with regard to various inflammatory diseases, yet the reports on their specific roles are not always consistent. They can be used as biomarkers to indicate or monitor disease or its progress, and also may serve as clinically applicable parameters for therapies. Yet, their precise role is not always clearly defined. Thus, in this review, we focus on the existing literature dealing with the biology of cytokines interleukin (IL)-6, IL-1, IL-33, tumor necrosis factor-alpha (TNF-α), IL-10, and IL-8. We will briefly focus on the correlations and role of these inflammatory mediators in the genesis of inflammatory impacts (e.g., shock, trauma, immune dysregulation, osteoporosis, and/or critical illness).

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Valor pronóstico de la interleucina 6 en la mortalidad de pacientes con sepsis

Cited by 13 publications

References 23 publications

IL-6 gene polymorphisms and sepsis in icu adult romanian patients: a prospective study

IL-6 gene polymorphisms and sepsis in icu adult romanian patients: a prospective study

Is Interleukin-6 a better predictor of successful antibiotic therapy than procalcitonin and C-reactive protein? A single center study in critically ill adults

Cytokines in Inflammatory Disease

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