Valorisation of phenols to coumarins through one-pot palladium-catalysed double C–H functionalizations

Abstract

Valorisation of phenols into high value-added products via step- and atom-efficient protocols is of great importance for the transition to sustainable chemical production. Among the transformation of phenols, C–H functionalization...

Classic vs. C–H functionalization strategies in the synthesis of APIs: a sustainability comparison

“…Nonetheless, it must also be considered that the C-H functionalization reactions were, for the most part, chronologically "novel" syntheses, which therefore have already been influenced by some behavioural and conceptual changes in organic synthesis, which are taking root in both the academy and industry. In addition, it is worth noting that the adoption of green technologies and strategies is continuously helping the transition towards more sustainable C-H functionalization methodologies [103][104][105][106][107][108][109][110][111] and, in these terms, the constant efforts in calculation and measurement of the greenness in its various declinations could be of importance for next-generation synthetic chemistry. Importantly, the development of techno-economic studies on the subject of the present review could certainly be of general interest and assist in an even more precise way the development of new chemical methodologies.…”

Csp2–H functionalization of phenols: an effective access route to valuable materials via Csp2–C bond formation

“…4 These scaffolds are crucial intermediates in synthetic organic chemistry making accessible the cyclization to O-heterocycle compounds. 46,164,165 For this reason the direct Csp 2 -H addition of olens to phenols is an attractive way to access those structures in an atom-efficient manner.…”

A Sustainable Access Route to Carbazoles via C–H/C–H Oxidative Functionalization/Cyclization of Arylamines

“…Given our long-term interest in optimizing the direct C–H functionalization of phenols and their derivatives, − as well as in cross-dehydrogenative coupling (CDC), we decided to direct our efforts toward developing a sustainable protocol for the conversion of diarylamines to carbazoles, which is currently only possible using a homogeneous nonrecoverable Pd catalyst, in combination with stoichiometric inorganic oxidants . Fagnou et al reported the synthesis of carbazoles by a homogeneous Pd-catalyzed oxidative protocol using air as a terminal oxidant …”