Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides

Abstract

Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of increasing interest. Thus, agri-food industry byproducts have emerged as a valuable source to obtain these hydrolysates as they are rich in proteins and inexpensive. Among these, byproducts from animal origin stand out as they are abundantly generated worldwide. Hence, this review is focused on evaluating the potential role of chicken slaughterhouse byproducts as a source of peptides for managing HTN. Several of these byproducts such as blood, bones, skins, and especially, chicken feet have been used to obtain protein hydrolysates with angiotensin-converting enzyme (ACE)-inhibitory activity and blood pressure-lowering effects. An increase in levels of endogenous antioxidant compounds, a reduction in ACE activity, and an improvement of HTN-associated endothelial dysfunction were the mechanisms underlying their effects. However, most of these studies were carried out in animal models, and further clinical studies are needed in order to confirm these antihypertensive properties. This would increase the value of these byproducts, contributing to the circular economy model of slaughterhouses.

Food By-Products and Agro-Industrial Wastes as a Source of β-Glucans for the Formulation of Novel Nutraceuticals

“…Current difficulties related to the increase in global population, together with food availability problems or environmental threats such as climate change, are encouraging the optimization of food system structures to achieve sustainable development goals within the framework of circular economy. In this line, the utilization of food by-products and agro-industrial wastes, that are massively and constantly generated, is a key point to reduce their negative impact from not only an environmental but also an economic point of view [ 73 , 74 ].…”

Effect of Dietary Supplementation of Soybean Bioactive Peptides and Vitamin E on Productive Performance and Some Carcass Characteristics in Broiler Chickens

“…Or may be due to the ability of certain peptides to improve gut morphology and function (such as secretion, anti-inflammatory interactions, and motility) and endocrine status compared to an equivalent amount of free amino acids [4]. It has been demonstrated that some peptides extracted from plant sources (Plant peptides) or animal peptides possess antimicrobial activities [28,2,29], antioxidants [9,10,3], and immunomodulatory [11,12], and all these characteristics improve the health status of birds, which is positively reflected in the improvement of their performance. Similar to our findings, Abdollahi et al [16,17] reported that the addition of 5.0 and 6.0 g/kg SBP to broiler diets improved FCR.…”

“…The addition of peptides is one of the alternatives offered in poultry nutrition, since peptides' function in bird feed has drawn more attention recently. When a protein is hydrolyzed chemically, enzymatically, or microbiologically, it releases specific small protein molecules called peptides, which are described as specific small protein molecules (2-20 amino acids) that can be isolated from animal byproducts or feeds derived from plants [3], peptides are high-quality tiny or big proteins having physiological, regulatory, or nutritional functions in poultry. Peptides are described as chains of amino acids that demonstrate a favorable physiological effect or offer a situation for such an effect in an organism's physiology [4] .…”

“…These peptides can be produced in a number of ways, such as for gastrointestinal digestion through proteolytic enzymes [6], or they can be produced in their bioactive form by enzymatic, alkaline or acid hydrolysis in vitro [7], or by microbial fermentation [8]. Several peptides secreted by plants or animals have antibacterial properties [2], with antioxidant capacity [9,10,3], and immunomodulators [11,12,13]. Those peptides isolated from different protein sources that have biological properties in addition to their nutritional value are referred to as "bioactive peptides."…”

Effects of Reducing Sugars on Colour, Amino Acids, and Volatile Flavour Compounds in Thermally Treated Minced Chicken Carcass Hydrolysate

“…Thus, our study was focused on fresh Kampong chicken carcasses. Some studies have been conducted to assess the suitability of chicken by-products for the manufacture of value-added products such as protein hydrolysates and polyunsaturated fatty acids [6][7][8]. The efficient utilisation of by-products represents a comprehensive strategy for minimizing losses.…”