Valorization of lipid-rich wastewaters: A theoretical analysis to tackle the competition between polyhydroxyalkanoate and triacylglyceride-storing populations

Argiz, Lucía; Correa‐Galeote, David; Río, Ángeles Val del; Mosquera-Corral, Anuska; González-Cabaleiro, Rebeca

doi:10.1016/j.scitotenv.2021.150761

Cited by 4 publications

(6 citation statements)

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“…Schematic representation of the location of diverse feedstocks with potential use as low-cost carbon sources for the production of PHAs. ,− …”

Section: Challenges For the Commercialization Of Phasmentioning

confidence: 99%

“…Argiz et al investigated the valorization of lipid-rich wastewaters for the production of triacylglycerides (TAG) and PHAs using different microbial cultures; they found that uncoupled carbon and nitrogen feedings, along with limited carbon excess, favor the formation of PHAs over TAG. They also reported maximum intracellular accumulations (as a sum of PHAs and TAG) of 38 and 32 wt % for uncoupled feeding periods and an accumulation of 15 wt % for a coupled feeding . However, using lipidic residues as a carbon source brings new challenges to these processes because these substrates are not soluble in the aqueous fermentation broth and, therefore, their solubilization into the media is crucial to maintain productivity.…”

Section: Challenges For the Commercialization Of Phasmentioning

confidence: 99%

“…If the carbon source is hydrophobic as in the case of lipids, solubilization via the addition of surfactants might be required to improve carbon availability to the cells. 133,139,140 Due to the presence of polysaccharides in alternative feedstocks, hydrolysis is also often an essential pretreatment step, as many PHA-producer organisms may not be able to readily process complex polysaccharides such as cellulose. 141−146 Finally, the detoxification or dilution of certain waste streams may be also required to avoid inhibition of cell growth or product synthesis.…”

Section: Identification and Utilization Of Alternative Feedstocksmentioning

confidence: 99%

“…They also reported maximum intracellular accumulations (as a sum of PHAs and TAG) of 38 and 32 wt % for uncoupled feeding periods and an accumulation of 15 wt % for a coupled feeding. 133 However, using lipidic residues as a carbon source brings new challenges to these processes because these substrates are not soluble in the aqueous fermentation broth and, therefore, their solubilization into the media is crucial to maintain productivity. Lignocellulosic materials are the most abundant biomass on the Earth's surface and are composed of lignin, cellulosic, and hemicellulosic fibers.…”

Section: Identification and Utilization Of Alternative Feedstocksmentioning

confidence: 99%

“…Importantly, structure, recalcitrance, and composition are the main factors that will determine the degree of pretreatment of feedstocks necessary for the formulation of a suitable fermentation media. ,− For example, an extraction is often required if the targeted carbon source is embedded in a complex matrix. If the carbon source is hydrophobic as in the case of lipids, solubilization via the addition of surfactants might be required to improve carbon availability to the cells. ,, Due to the presence of polysaccharides in alternative feedstocks, hydrolysis is also often an essential pretreatment step, as many PHA-producer organisms may not be able to readily process complex polysaccharides such as cellulose. − Finally, the detoxification or dilution of certain waste streams may be also required to avoid inhibition of cell growth or product synthesis. In some cases, and even though the pretreatment of these alternative feedstocks can be regarded as an additional cost, these strategies can significantly decrease the overall cost of the production process when compared to the costs of utilizing pure carbon sources.…”

Section: Challenges For the Commercialization Of Phasmentioning

confidence: 99%

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Polyhydroxyalkanoates Production: A Challenge for the Plastic Industry

Guzmán-Lagunes,

Wongsirichot,

Winterburn

et al. 2023

Ind. Eng. Chem. Res.

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The accumulation of petroleum-based plastics in the environment has heightened the necessity of finding alternative materials with similar properties and lower environmental impact. Polyhydroxyalkanoates (PHAs) are a group of naturally occurring polyesters that have been investigated for several decades as potential substitutes for commonly used plastics. PHAs are biodegradable and biocompatible polymers derived from renewable resources. From this point of view, their industrial implementation represents an attractive strategy to reduce plastic pollution and petroleum dependency. Nevertheless, the high production costs related to these materials have considerably hindered their broader use and commercialization. In this regard, several approaches have been proposed to turn their production competitive from a commercial perspective. For instance, several studies have scrutinized the different production steps of PHAs in terms of economic viability. Reported strategies include optimization of fermentation processes; selection, isolation, and genetic modification of microbial strains; selection of low-cost renewable raw materials; and more efficient separation processes of the produced PHAs. This review summarizes the main advantages and disadvantages of different strategies proposed to improve the competitiveness of PHAs production; potential applications of PHAs manufactured by these different methods, as well as the main challenges to be overcome to develop economically viable industrial processes, are discussed in detail.

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