Valosin-Containing Protein is a Novel Autoantigen in Patients with Glaucoma

Lee, Koon-Ja; Jeong, Seon-Mi; Hoehn, Benjamin Douglass; Hong, Young Jae; Lee, Sung Ho

doi:10.1097/opx.0b013e3181fa6312

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…The conventional school of thought has been that glaucoma is a etiologically linked to an elevated intraocular pressure (IOP) . This view has persisted throughout much of the 20th century and was only challenged after pioneering clinical research by Armaly in which he discovered that the majority of patients in his study with IOPs above 21 mmHg did not go on to develop visual field losses over a 7 year period.…”

Section: Introductionmentioning

confidence: 99%

Influence of central corneal thickness on measured intraocular pressure differentials: Nidek RKT‐7700, Topcon CT‐80 NCTs and Goldmann Tonometer

Ogbuehi

Mucke

Osuagwu

2012

Ophthalmic Physiologic Optic

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Section: Introductionmentioning

confidence: 99%

Influence of central corneal thickness on measured intraocular pressure differentials: Nidek RKT‐7700, Topcon CT‐80 NCTs and Goldmann Tonometer

Ogbuehi

Mucke

Osuagwu

2012

Ophthalmic Physiologic Optic

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Western blot patterns of serum autoantibodies against optic nerve antigens in dogs with goniodysgenesis-related glaucoma

Pumphrey

Pizzirani²,

Pirie³

et al. 2013

ajvr

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Objective To investigate whether differences existed between clinically normal dogs and dogs with goniodysgenesis-related glaucoma (GDRG) in serum autoantibodies against optic nerve antigens. Animals 16 dogs with GDRG, 17 healthy dogs with unremarkable pectinate ligament and iridocorneal angle morphology, and 13 euthanized dogs with no major ocular abnormalities or underlying diseases. Procedures Western blotting was performed with optic nerve extracts from the euthanized dogs as an antigen source and serum from clinically normal dogs and dogs with GDRG as a primary antibody (autoantibody) source. Blots were evaluated for presence and density of bands. Results Multiple bands were identified on western blots from all dogs with GDRG and all clinically normal dogs, with a high degree of variability among individual dogs. Dogs with GDRG were significantly more likely than healthy dogs to have bands present at 38, 40, and 68 kDa. Dogs with GDRG had significant increases in autoreactivity at 40 and 53 kDa and a significant decrease in autoreactivity at 48 kDa. Conclusions and Clinical Relevance Significant differences in serum autoantibodies against optic nerve antigens were found in dogs with versus without GDRG. Although it remains unclear whether these differences were part of the pathogenesis of disease or were sequelae to glaucomatous changes, these findings provide support for the hypothesis that immune-mediated mechanisms play a role in the development or progression of GDRG. However, the high degree of variability among individual dogs and the considerable overlap between groups suggest that the clinical usefulness of this technique for distinguishing dogs with GDRG from clinically normal dogs is likely limited.

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Valosin-Containing Protein is a Novel Autoantigen in Patients with Glaucoma

Abstract: VCP represents a potential candidate target for autoantibodies on the optic nerve in patients with glaucoma.

Cited by 2 publications

References 33 publications

Influence of central corneal thickness on measured intraocular pressure differentials: Nidek RKT‐7700, Topcon CT‐80 NCTs and Goldmann Tonometer

Influence of central corneal thickness on measured intraocular pressure differentials: Nidek RKT‐7700, Topcon CT‐80 NCTs and Goldmann Tonometer

Western blot patterns of serum autoantibodies against optic nerve antigens in dogs with goniodysgenesis-related glaucoma

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