Valproic acid and sleep apnoea: A disproportionality signal from the WHO pharmacovigilance database

Revol, Bruno; Jullian‐Desayes, Ingrid; Guichard, Kelly; Micoulaud‐Franchi, Jean‐Arthur; Tamisier, Renaud; Philip, Pierre; Joyeux‐Faure, Marie; Pépin, Jean‐Louis

doi:10.1111/resp.13771

Cited by 3 publications

(3 citation statements)

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“…It has been shown that among the 72,821 adverse drug reactions reported by health professionals for VA, there were 56 cases of sleep apnea syndrome. 1 Two mechanisms are proposed to explain by which VA induces CSA. The first one is the depression of the central ventilatory drive.…”

Section: Discussionmentioning

confidence: 99%

“… 9 The second mechanism for CSA occurrence is that VA causes instability of ventilator control. 1 So, patients treated with VA should be screened for CSA. Given the importance of understanding the underlying mechanisms, sleep physicians and neurologists must collaborate closely when dealing with CSA.…”

Section: Discussionmentioning

confidence: 99%

“…Robust evidence substantiates a functional interplay between epilepsy and sleep dynamics, as elucidated in prior research studies. 1 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Reversible central respiratory events induced by valproic acid treatment: A case report

Moussa,

Mahmoud,

Rouis

et al. 2024

SAGE Open Medical Case Reports

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Valproic acid holds a prominent position as the primary therapeutic option for epilepsy cases. The utilization of antiepileptic agents like valproic acid has been linked to disturbances in sleep architecture. Although scant, there exists a subset of studies that allude to the potential manifestation of sleep apnea as an adverse effect of valproic acid administration. In this context, we present a case report of a 76-year-old man with a past medical history of arterial hypertension, atrial fibrillation, and obstructive sleep apnea syndrome treated with continuous positive airway pressure since 2020. Following the commencement of valproic acid treatment for vascular epilepsy, obstructive sleep apnea evolved toward to central sleep apnea. This case exemplifies the need for a heightened awareness of the multifaceted implications of valproic acid therapy on sleep patterns.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%