Valproic Acid-induced Hearing Loss and Tinnitus

Hori, Ariyuki; Kataoka, Satoshi; Sakai, Koichiro; Hirose, Genjiro; Iwasaki, Noriko; Horiguchi, Akiko; Takashima, Masayuki; Tomoda, Koichi

doi:10.2169/internalmedicine.42.1153

Cited by 14 publications

(21 citation statements)

References 2 publications

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“…It is used as monotherapy or adjuvant therapy in various types of seizures. Some cases of sensorineural hearing loss by using this drug have been reported in the literature [2,3]. Although the mechanism of the hearing loss associated with VPA is not known exactly, it is speculated that the defects in the electromagnetic conductance of the sound at the hairy cells of the cochlea or conductance of nerve impulses may be responsible for this side effect [4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

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Effects of valproic acid on hearing in epileptic patients

İncecik¹,

Akoğlu²,

Sangün³

et al. 2007

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

“…Hori et al presented two patients who were 9 and 20 years old and had sensorineural hearing loss related with VPA [3]. Hearing loss was diagnosed 1 month later in the first one and 2 months in the second one after the first dosage of the therapy.…”

Section: Discussionmentioning

confidence: 99%

Effects of valproic acid on hearing in epileptic patients

İncecik¹,

Akoğlu²,

Sangün³

et al. 2007

International Journal of Pediatric Otorhinolaryngology

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“…Remarkably, there are two case reports about reversible sensorineural hearing loss induced by valproic acid, an inhibitor of HDAC (Armon et al, 1990). Hori et al (2003) reported valproic acidinduced hearing loss and tinnitus. Prestin expression might have been affected in these patients.…”

Section: Modulation Of Histone Status Affects Prestin Expressionmentioning

confidence: 99%

Effects of retinoic acid and butyric acid on the expression of prestin and gata‐3 in organotypic cultures of the organ of corti of newborn rats

Gross

Stute

Fuchs

et al. 2011

Developmental Neurobiology

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Prestin is the motor protein of the outer hair cells of the organ of Corti and a key factor in ensuring a high level of sensitivity of mammalian hearing. The factors that influence prestin expression are still largely unknown. We studied the effects of the application of retinoic acid, a ligand of a nuclear receptor, and of butyric acid, an inhibitor of histone deacetylase activity, on the expression of mRNA of prestin and Gata-3 in the organotypic culture of the organ of Corti of newborn rats using RT-PCR. Application of retinoic acid at concentrations of 1-50 μM results in a dose-dependent expression decrease after two days in culture. Treatment with sodium butyrate (0.5-2 mM) elevated the expression of prestin and Gata-3. Statistically significant correlations between Gata-3 and prestin mRNA levels were observed under all conditions. The data indicate that retinoid nuclear transcription factors, GATA-3 and histone acetylation/deacetylation processes may have a regulatory role to play in prestin expression.

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“…However a singlecase has been reported suggesting its potential role in inducing tinnitus (eventually by magnesium metabolism impairment),85,86 with tinnitus eventually being misinterpreted as psychotic symptom 87. The only RCT evidence for lamotrigine concluded it to be ineffective for tinnitus 88…”

Section: Psychopharmacological Treatmentmentioning

confidence: 99%

Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management

Fornaro

Martino

2010

NDT

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Background:Subjective tinnitus is a frequent, impairing condition, which may also cause neurotransmitter imbalance at the cochlea. Psychopharmacologic agents, although not being the first-line treatment for tinnitus, may modulate cochlear neurotransmission, thereby influencing the subjective tinnitus experience.Method:A comprehensive review of MEDLINE literature (from January 1990–January 2010) was performed searching for: “tinnitus”, major classes of psychopharmacological agents, and psychiatric disorders. The most relevant clinical evidence is reported briefly along with a concise description of the main neurotransmitters purported to be involved in tinnitus, in order to provide the reader with a rational evaluation of tinnitus therapy with psychopharmacological agents.Results:Although strong methodological issues limit the reliability of the current results, a broad number of psychopharmacological agents have already been considered for tinnitus, both as candidate triggers or potential therapies.Conclusions:Selected psychopharmacological drugs may play a role in the clinical management of this disorder. While the rational use of these agents for the treatment of tinnitus should not be overlooked, research should be undertaken on their neuromodulating actions at the cochlea.

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Valproic Acid-induced Hearing Loss and Tinnitus

Cited by 14 publications

References 2 publications

Effects of valproic acid on hearing in epileptic patients

Effects of valproic acid on hearing in epileptic patients

Effects of retinoic acid and butyric acid on the expression of prestin and gata‐3 in organotypic cultures of the organ of corti of newborn rats

Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management

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