Valproic Acid-Induced Hyperpigmentation

doi:10.20431/2456-0022.0201003

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…On the other hand, SV-VPA causes cutaneous drug eruptions [8]. Cutaneous drug eruptions associated with SV-VPA can range from hyperpigmentation [9] to severe Stevens-Johnson syndrome [10]. Localized morphea [11], Rowell's syndrome [12], acute generalized exanthematous pustulosis [13], cutaneous pseudolymphoma [14], and Henoch-Schönlein purpura [15] are some rare cutaneous side effects due to VPA.…”

Section: Discussionmentioning

confidence: 99%

Reversible bilateral postauricular adult seborrheic dermatitis due to sodium valproate-valproic acid combination

Örüm,

Çevik

2024

Troia Med J

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The combination of sodium valproate-valproic acid, commonly used to treat epilepsy and bipolar disor-der, may result in cutaneous reactions. In this case report, we presented a bilateral postauricular sebor-rheic dermatitis associated with sodium valproate-valproic acid use. A sodium valproate-valproic acid combination was introduced to the therapy of a 68-year-old male patient who had been diagnosed with schizophrenia and was on clozapine in order to potentially avoid seizures associated to the medication. On the fifteenth day of drug addition, crusting appeared on the back skin of both ears of the patient. While the patient had a history of clozapine use, there was no history of sodium valproate use or similar cutaneous symptoms. The current condition was associated with the sodium valproate-valproic acid combination and the drug was discontinued. Following discontinuation of the medication, the crusting decreased and disappeared completely after two weeks. The patient's schizophrenia-related treatment was completed and he was discharged. No cutaneous reaction was observed again during follow-up. It should be noted that cutaneous reactions may be associated with the use of sodium valproate-valproic acid combination.

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Section: Discussionmentioning

confidence: 99%

Reversible bilateral postauricular adult seborrheic dermatitis due to sodium valproate-valproic acid combination

Örüm,

Çevik

2024

Troia Med J

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Drug-Induced Hyperpigmentation: Review and Case Series

García

Carrasco-Molina

2019

J Am Board Fam Med

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Background: Hyperpigmentation is a common dermatologic problem that may have substantial impact on the patient, since it affects the appearance and quality of life, and may influence treatment adherence. There are few studies of drug-induced hyperpigmentation. Methods: We studied drug-induced hyperpigmentation in patients attending an outpatient dermatology clinic in the Western Area of Valladolid (Spain) from August 1, 2017 to April 20, 2018. Results: The incidence of drug-induced hyperpigmentation was 1.31% in patients attending a first dermatology consultation in the study period. Of the 16 patients, 8 were taking more than 1 drug. The most frequent drugs identified were nonsteroidal anti-inflammatory agents (25%), antihypertensive agents (18.75%), antimalarials (12.5%), antibiotics, antineoplastic agents, psychoactive agents, simvastatin, allopurinol, amiodarone and mucolytic (6.25% each). Hyperpigmentation was found in the mucosa in 25% of patients and in photograph-exposed areas in 37.5%. Discussion: Diagnosing drug-induced hyperpigmentation is a dermatologic challenge. A differential diagnosis with hyperpigmentation caused by endocrine and metabolic disorders, the most closely-related disorders to drug-induced hyperpigmentation, and with hyperpigmentation of idiopathic origin, should be conducted. Drug-induced hyperpigmentation is a relatively frequent reason for consultation, especially in polypharmacy patients. The sample may have been biased as many patients receiving treatments frequently associated with drug-induced hyperpigmentation, such as antineoplastic drugs, are diagnosed and treated by other specialties, such as oncologists. Conclusion: Family physicians and specialists should consider drugs as a cause of hyperpigmentation to facilitate the correct diagnosis and treatment.

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Nail Hyperpigmentation Following Valproic Acid Use: A Rare Case Report

Biswal¹,

Kunwar²

2023

Indian Journal of Private Psychiatry

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Valproic Acid-Induced Hyperpigmentation

Cited by 3 publications

References 19 publications

Reversible bilateral postauricular adult seborrheic dermatitis due to sodium valproate-valproic acid combination

Reversible bilateral postauricular adult seborrheic dermatitis due to sodium valproate-valproic acid combination

Drug-Induced Hyperpigmentation: Review and Case Series

Nail Hyperpigmentation Following Valproic Acid Use: A Rare Case Report

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