Valproic acid promotes human hair growth in in vitro culture model

Jo, Seong Jin; Choi, Soon Jin; Yoon, Sun Young; Lee, Ji Yeon; Park, Won Seok; Park, Phil June; Kim, Kyu Han; Eun, Hee Chul; Kwon, Oh Sang

doi:10.1016/j.jdermsci.2013.05.007

Cited by 51 publications

(52 citation statements)

References 62 publications

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“…The WNT/ β ‐catenin pathway has recently received attention as a therapeutic target in AGA because androgens have been shown to inhibit its expression . Topical valproate – a known activator of WNT signals – has been shown to promote hair regeneration and induce the expression of dermal papilla markers . In an organ culture model, valproate increased the viability of human dermal papilla cells, promoted elongation of the hair shaft, and reduced catagen transition of human hair follicles .…”

Section: Discussionmentioning

confidence: 99%

“…Topical valproate – a known activator of WNT signals – has been shown to promote hair regeneration and induce the expression of dermal papilla markers . In an organ culture model, valproate increased the viability of human dermal papilla cells, promoted elongation of the hair shaft, and reduced catagen transition of human hair follicles . Interestingly, a 24‐week clinical feasibility study has recently shown that 8.3% topical valproate can increase total hair count of AGA patients .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Topical application of the Wnt/β‐catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia

Tosti

Zaiac

Canazza

et al. 2016

J of Cosmetic Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Topical application of the Wnt/β‐catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia

Tosti

Zaiac

Canazza

et al. 2016

J of Cosmetic Dermatology

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“…Valproic acid exhibits to promote hair growth through inhibition of GSK-3β activity and stabilization of β-catenin [91]. In addition, enzastaurin (LY317615) has been developed as an inhibitor of PKCβ to reduce GSK-3β activity through inhibiting GSK-3β phosphorylation at phase I and II in clinical tests [92].…”

Section: Clinical Prospectivementioning

confidence: 99%

The Key Roles of GSK-3β in Regulating Mitochondrial Activity

Yang

Chen

Gao

et al. 2017

Cell Physiol Biochem

184

119

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Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, has been reported to show essential roles in molecular pathophysiology of many diseases. Mitochondrion is a dynamic organelle for producing cellular energy and determining cell fates. Stress-induced translocated GSK-3β may interact with mitochondrial proteins, including PI3K-Akt, PGC-1α, HK II, PKCε, components of respiratory chain, and subunits of mPTP. Mitochondrial pool of GSK-3β has been implicated in mediation of mitochondrial functions. GSK-3β exhibits the regulatory effects on mitochondrial biogenesis, mitochondrial bioenergetics, mitochondrial permeability, mitochondrial motility, and mitochondrial apoptosis. The versatile functions of GSK-3β might be associated with its wide range of substrates. Accumulative evidence demonstrates that GSK-3β inactivation may be potentially developed as the promising strategy in management of many diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Intensive efforts have been made for exploring GSK-3β inhibitors. Natural products provide us a great source for screening new lead compounds in inactivation of GSK-3β. The key roles of GSK-3β in mediation of mitochondrial functions are discussed in this review.

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“…It is worth noting that although mouse skin and hair growth on mouse skin do not resemble human skin in many aspects, studies with many hair growth inhibitors and hair growth promoting drugs have been performed with different strains of mice, including the C57BL/6 mice used in the present study (Jo et al 2013; Kang et al 2013), and it is expected that the information learned using mice and mouse skin in the present study will likely be useful in designing improved eflornithine therapy of unwanted hair growth in humans in the future. Further investigation is still needed to evaluate the safety of this microneedle-based modality in enhancing the eflornithine cream’s ability to inhibit hair re-growth.…”

Section: Resultsmentioning

confidence: 99%

A method to improve the efficacy of topical eflornithine hydrochloride cream

et al. 2014

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Context Facial hirsutism is a cosmetic concern for women and can lead to significant anxiety and lack of self-esteem. Eflornithine cream is indicated for the treatment of facial hirsutism. However, limited success rate and overall patient’s satisfaction, even with a long-term and high frequency application, leave room for improvement. Objective The objective of this study is to test the effect of microneedle treatment on the in vitro skin permeation and the in vivo efficacy of eflornithine cream in a mouse model. Materials and method In vitro permeation study of eflornithine was performed using Franz diffusion cell. In vivo efficacy study was performed in a mouse model by monitoring the re-growth of hair in the lower dorsal skin of mice after the eflornithine cream was applied onto an area pretreated with microneedles. The skin and the hair follicles in the treated area were also examined histologically. Results and discussion The hair growth inhibitory activity of eflornithine was significantly enhanced when the eflornithine cream was applied onto a mouse skin area pretreated with microneedles, most likely because the micropores created by microneedles allowed the permeation of eflornithine into the skin, as confirmed in an in vitro permeation study. Immunohistochemistry data revealed that cell proliferation in the skin and hair follicles was also significantly inhibited when the eflornithine cream was applied onto a skin area pretreated with microneedles. Conclusion The integration of microneedle treatment into topical eflornithine therapy represents a potentially viable approach to increase eflornithine’s ability to inhibit hair growth.

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Valproic acid promotes human hair growth in in vitro culture model

Cited by 51 publications

References 62 publications

Topical application of the Wnt/β‐catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia

Topical application of the Wnt/β‐catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia

The Key Roles of GSK-3β in Regulating Mitochondrial Activity

A method to improve the efficacy of topical eflornithine hydrochloride cream

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