Valsalva manoeuvre-induced pneumothorax and pneumomediastinum in a COVID-19 patient with ARDS: an unusual mechanism for this complication

Abstract

Background: Until now, only a few cases of Valsalva-induced barotraumas (pneumothorax, pneumomediastinum and subcutaneous emphysema) have been described, and none of them among COVID-19 patients. Case description: A man in his 50s was admitted for SARS-CoV-2-related acute respiratory distress syndrome (ARDS). Initial evolution was favourable with non-invasive ventilatory support, high-flow oxygen nasal cannula and the best supportive drugs available at the time. During the Valsalva manoeuvre while defecating, the patient reported sudden chest pain and showed a new acute hypoxemic respiratory failure due to a pneumothorax. It led to multiple complications (pulmonary embolism, haemoptysis, and cardiac arrest), and despite the best supportive care, led to the patient's death. Discussion: The Valsalva manoeuvre can be an overlooked cause of pneumothorax in patients with COVID-19. Predisposition to barotrauma in COVID-19 patients could be explained by several factors, including the extensive use of non-invasive and invasive ventilation during the pandemic, and the histological changes observed in the lungs of those infected with COVID-19. Conclusion: We report the first description of a Valsalva-induced barotrauma in a COVID-19 infection. We emphasise the importance of treating constipation particularly in severe COVID-19 cases, to prevent complications such as barotrauma.

Spontaneous pneumothorax risk factor mapping: A Mendelian randomization study

“…In previous studies, height [19] , weight [20] , and body mass index [21] have been identified as risk factors for spontaneous pneumothorax. In this study, a causal relationship between excessive height and increased risk of spontaneous pneumothorax was confirmed, and there was limited evidence of a causal relationship between body weight, body mass index and spontaneous pneumothorax.…”