Valsalva Responses and Systolic Time Intervals During Anaesthesia and Induced Hypotension

Blackburn, J. P.; Conway, C.M.; Davies, Russell M.; Enderby, G. E. H.; Edridge, A; Leigh, Julian M.; Lindop, M. J.; Phillips, Glenys; Strickland, D.A.P.; Tennant, R.; Knight, Hilary

doi:10.1093/bja/45.7.704

Cited by 18 publications

(9 citation statements)

References 12 publications

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“…Cardiac output decreased by a mean of 0.5 L after manual hyperinflation, which in an animal with a mean cardiac output of 3.5 L would be clinically significant. The effects of increased intrathoracic pressure in an intubated patient have been described previously in a large study (Blackburn et al, 1973). Initially there is a compression of vessels in the pulmonary system, providing increased blood flow to the left ventricle, increasing its preload and therefore the stroke volume.…”

Section: Discussionmentioning

confidence: 87%

Effect of manual hyperinflation on haemodynamics in an animal model

Anning

Paratz

Wong

et al. 2003

Physiotherapy Res Intl

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Significant haemodynamic changes occurred in this animal model. The increased intrathoracic pressure, applied for an increased period during inspiration, decreased cardiac output with compensatory vasoconstriction evident by the increased systemic vascular resistance and mean arterial pressure. The results suggest that there may be a decrease in cardiac output after increased positive pressure in subjects with normal cardiac and respiratory function.

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Section: Discussionmentioning

confidence: 87%

Effect of manual hyperinflation on haemodynamics in an animal model

Anning

Paratz

Wong

et al. 2003

Physiotherapy Res Intl

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“…The parameters were noted every minute for 5 min and a final recording was made a t the tenth minute. Each measurement period consisted of ten consecutive cardiac systoles recorded during an apnoeic phase (obtained by manually switching a respiratory valve), in order to reduce the variations of systolic time intervals due to intermittent positive-pressure breathing (BLACKBURN et al 1973).…”

Section: Haemodynamic Tes! Methodologymentioning

confidence: 99%

Haemodynamic Changes Associated with Atropine/Neostigmine Administration: A Non‐invasive Investigation

d'Hollander¹,

Dewachter²,

Deville³

et al. 1981

Acta Anaesthesiol Scand

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Stroke volume, systolic time intervals and related index variations induced by atropine/neostigmine (AN) (0.75 mg/l mg) decurarization mixture were investigated by non-invasive methods (ECG, phonocardiogram, thoracic impedance) in 15 anaesthetized normocapnic patients in a stable state after induction of anaesthesia and prior to surgical stimulation. Data showed decrease in mean heart rate (HR) (initial value: 82 beats/min; after 10 min: 57 beats/min; P less than 0.001) accompanied by an increase in stroke volume (SV) (initial value: 75 ml, after 10 min: 100 ml; P less than 0.001). No alterations in myocardial contractility were noted with the systolic time intervals (PEP, PEP/LVET, 1/PEP2). Under the conditions of the study, the negative chronotropic effect of AN mixture was not accompanied by a negative inotropic state.

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“…There are, however, two methods of inducing hypotension in which cardiac output may decline considerably in response to IPPV, as a result of temporary autonomic paralysis. Both ganglion blocking drugs and beta adrenoceptor antagonists may partially or completely block the Valsalva response [3], thus limiting the normal compensatory mechanism.…”

Section: Cardiovascular Physiologymentioning

confidence: 99%

Perioperative Blood Loss and Its Reduction: The Role of the Anaesthetist

Simpson

1992

British Journal of Anaesthesia

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Valsalva Responses and Systolic Time Intervals During Anaesthesia and Induced Hypotension

Cited by 18 publications

References 12 publications

Effect of manual hyperinflation on haemodynamics in an animal model

Effect of manual hyperinflation on haemodynamics in an animal model

Haemodynamic Changes Associated with Atropine/Neostigmine Administration: A Non‐invasive Investigation

Perioperative Blood Loss and Its Reduction: The Role of the Anaesthetist

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