Valsartan/Hydrochlorothiazide Induced Pemphigus Foliaceus

Abstract

Valsartan is an angiotensin II receptor blocker (ARB), a newer class of antihypertensives. Rarely some skin condition such as angioedema, urticarial, photosensitive rash, lichenoid eruption, pseudolymphomatous eruption and bullous pemphigoid, induced by valsartan have been

New onset of pemphigus foliaceus following BNT162b2 vaccine

“…There is one case of valsartan and hydrochlorothiazide induced PF in the literature, and we cannot confidently disregard the possible effect. 9 However, the onset of the initial lesions after the first dose of vaccine and the exacerbation with new‐onset generalized lesions after the second dose suggest the association with mRNA vaccine. In our case, disease course was controlled easily with the proper treatment regimen.…”

Pemphigus Foliaceous after COVID-19 Infection and Bamlanivimab Infusion

“…5 PF is the most common variant of druginduced pemphigus when caused by thiol containing drugs. 7 Although this patient is taking lisinopril, which contains an amide group, drug-induced pemphigus is more rare among angiotensin converting enzyme inhibitors other than captopril. Additionally, DISCUSSION metoprolol could be considered as a possible inciting drug as there are reports of beta-blockers causing drug-induced pemphigus.…”

“…Additionally, DISCUSSION metoprolol could be considered as a possible inciting drug as there are reports of beta-blockers causing drug-induced pemphigus. 7 Bamlanivimab is favored as the most likely inciting agent in this case based on timeline of disease presentation. A review of 170 drug-induced pemphigus cases found that patients developed pemphigus within a mean of 154.27 days.…”