Value: Changes in the Detection and Recognition Thresholds of Three Basic Tastes in Lung Cancer Patients Receiving Cisplatin and Paclitaxel and Its Association with Nutritional and Quality of Life Parameters

Turcott, J.; Juárez-Hernández, Eva; Torre-Vallejo, Martha De La; Sánchez-Lara, Karla; Luvian-Morales, Julissa; Arrieta, Óscar

doi:10.1080/01635581.2016.1144075

Cited by 37 publications

(30 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taste alterations, such as chemotherapy-induced oral mucositis, were found to be related to dysgeusia. [1,27] The present study showed higher taste alterations in patients with nausea, vomiting, loss of appetite and mucositis, corroborating previous studies.…”

Section: Characteristics Of Taste Alterationsupporting

confidence: 92%

Taste Alteration in Cancer Patients Receiving Chemotherapy: A Cross-Sectional Study

Arıkan¹

2019

TJ Oncol

View full text Add to dashboard Cite

This study aimed to investigate nutrition in cancer patients, chemotherapy-induced taste alterations and the factors affecting these taste alterations. METHODS This study was planned as a cross-sectional study. Patients who had received chemotherapy at least once and had been on chemotherapy for the last 7-10 days (n=112) were included in this study. The data were collected using the Patient-Generated Subjective Global Assessment, the National Cancer Institute's Common Terminology Criteria for Adverse Events and the Chemotherapy-induced Taste Alteration Scale (CiTAS). RESULTS The CiTAS score was higher in female cancer patients. Patients with nausea 2.19 (SD=1.00) and vomiting 3.13 (SD=1.21) had higher scores on the taste disorder subscale of the CiTAS, while patients with vomiting 3.00 (SD=1.42) had higher scores on the general taste alterations subscale (p<0.05). Patients with constipation received high scores on the subscales of reduction in intake of the basic tastes, taste disorder, and general taste alterations 2.50 (SD=1.27) (p<0.05). Patients with a lack of appetite obtained high scores on the subscales of reduction in the intake of the basic tastes, taste disorder, phantogeusia, parageusia, and general taste alterations 2.64 (SD=1.29) (p<0.05). Mild malnutrition was observed in 24.6% of the patients. CONCLUSION This study revealed that taste alteration was higher in female and early-stage patients and more severe in patients with nausea, vomiting, constipation, and mucositis. Taste alteration was found to be greater in patients with poor nutritional status.

show abstract

Section: Characteristics Of Taste Alterationsupporting

confidence: 92%

Taste Alteration in Cancer Patients Receiving Chemotherapy: A Cross-Sectional Study

Arıkan¹

2019

TJ Oncol

View full text Add to dashboard Cite

show abstract

“…We also found that paclitaxel-treated mice exhibit increased immobility time during FST and anhedonia-like behavior in the sucrose preference test. The observed decrease in sucrose preference could also indicate that an alteration in taste (dysgeusia), a phenomenon seen in some patients receiving paclitaxel (Turcott et al, 2016), is occurring during paclitaxel treatment; yet, we cannot make that conclusion from a single oral consumption assay. The possible taste alteration may produce decreased appetite, but no significant changes in body weight were detected.…”

Section: Discussionmentioning

confidence: 90%

Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse

et al. 2017

View full text Add to dashboard Cite

Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively extends the progression-free survival of breast, lung, and ovarian cancer patients. However, paclitaxel and other chemotherapy drugs elicit peripheral nerve fiber dysfunction or degeneration that leads to peripheral neuropathy in a large proportion of cancer patients. Patients receiving chemotherapy also often experience changes in mood, including anxiety and depression. These somatic and affective disorders represent major dose-limiting side effects of chemotherapy. Consequently, the present study was designed to develop a preclinical model of paclitaxel-induced negative affective symptoms in order to identify treatment strategies and their underlying mechanisms of action. Intraperitoneal injections of paclitaxel (8 mg/kg) resulted in the development and maintenance of mechanical and cold allodynia. Carboplatin, another cancer chemotherapeutic drug that is often used in combination with paclitaxel, sensitized mice to the nociceptive effects of paclitaxel. Paclitaxel also induced anxiety-like behavior, as assessed in the novelty suppressed feeding and light/dark box tests. In addition, paclitaxel-treated mice displayed depression-like behavior during the forced swim test and an anhedonia-like state in the sucrose preference test. In summary, paclitaxel produced altered behaviors in assays modeling affective states in C57BL/6J male mice, while increases in nociceptive responses were longer in duration. The characterization of this preclinical model of chemotherapy-induced allodynia and affective symptoms, possibly related to neuropathic pain, provides the basis for determining the mechanism(s) underlying severe side effects elicited by paclitaxel, as well as for predicting the efficacy of potential therapeutic interventions.

show abstract

“…In one of these three studies, the reduced ability to identify taste solutions was associated with decreased energy intake during the beginning of the third chemotherapy treatment cycle [25]. In a second study, patients who became more sensitive to sucrose between the start of chemotherapy and after two cycles of chemotherapy consumed fewer grams of protein, animal protein, fat, and iron compared to those who became less sensitive to sucrose [26]. The third study also found a relationship between sweet sensitivity and food behavior, reporting that decreased sucrose sensitivity was associated with reduced appetite prior to treatment [20].…”

Section: Resultsmentioning

confidence: 99%

Chemosensory Changes from Cancer Treatment and Their Effects on Patients’ Food Behavior: A Scoping Review

et al. 2019

View full text Add to dashboard Cite

Individuals undergoing treatment for cancer can experience changes in taste or smell that are often assumed to affect constructs related to food behavior, although this relationship is rarely measured directly. To ascertain the extent to which measured changes in taste and smell during and after cancer treatment affect food behavior, we conducted a scoping review and completed a comparative analysis for studies that met our criteria, which were: they directly measured cancer patients’ (a) psychophysical response to taste and/or olfactory stimuli, and (b) food behavior (including food enjoyment, food preference, dietary intake) in people affected by cancer. Eleven studies met these criteria and were included in the review. All 11 studies evaluated taste and five also measured smell. A comparative analysis exploring taste and food behavior shows that a reduced sweet taste function (decreased sensitivity) was associated with a reduced intake of a variety of different macro and micro nutrients, reduced appetite, and overall lower energy intake. One out of six studies that measured smell and food measured observed changes in olfactory function following cancer treatment. There were no significant relationships reported between olfactory measures and food behavior. Taste changes that arise from cancer treatment appear to have a direct effect on food behavior, although there is a need for more research using standardized measures and larger sample sizes. A better understanding of taste alterations and their implications for dietary intake and food enjoyment will support optimal nutritional health by identifying strategies to help patients eat well during and after cancer treatment.

show abstract

Value: Changes in the Detection and Recognition Thresholds of Three Basic Tastes in Lung Cancer Patients Receiving Cisplatin and Paclitaxel and Its Association with Nutritional and Quality of Life Parameters

Cited by 37 publications

References 36 publications

Taste Alteration in Cancer Patients Receiving Chemotherapy: A Cross-Sectional Study

Taste Alteration in Cancer Patients Receiving Chemotherapy: A Cross-Sectional Study

Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse

Chemosensory Changes from Cancer Treatment and Their Effects on Patients’ Food Behavior: A Scoping Review

Contact Info

Product

Resources

About