“…The narrative review on cost-effectiveness of prevention initiatives was limited as most research has focused on targeted health conditions. In total, 33 studies on cost-effectiveness were reviewed: systematic reviews (n = 9) ( Baicker et al, 2010 ; Chapman, 2012 ; Edwards et al, 2013 ; Goetzel et al, 2005 ; Grosse et al, 2007 ; Korczak et al, 2011 ; Krause, 2005 ; Mattke et al, 2007 ; Weatherly et al, 2009 ), observational studies (n = 13) ( Ahn et al, 2015 ; Billings and Mijanovich, 2007 ; Brown, 2014 ; Diaz et al, 2015 ; Hung et al, 2007 ; Linden, 2006 ; Mays and Smith, 2011 ; Ormond et al, 2011 ; Phillips et al, 2013 ; Schwartz et al, 2010 ; Thorpe and Yang, 2011 ; Wang et al, 2003 ; Zhuo et al, 2012 ), randomized controlled trials (n = 2) ( Ackermann et al, 2008 ; Holmes et al, 2008 ), white papers (n = 4) ( Levi et al, 2010 ; Institute on Urban Health Research and Practice, 2013 ; Chen et al, 2016 ; Schmidt et al, 2012 ), and perspective pieces (n = 5) ( Baxter, 2010 ; Brush, 2013 ; Bodenheimer, 2003 ; Jacobs, 2012 ; Russell, 2009 ). This literature revealed that: 1) clinical settings are not as cost-effective as community-based settings, 2) while programs can be cost-effective, they are rarely cost-saving, and 3) extended time horizons are suitable for prevention programming as benefits (and costs) may not be realized for some time.…”