Value of 18-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients With Cystic Tumors of the Pancreas

Sperti, Cosimo; Pasquali, Claudio; Chierichetti, Franca; Liessi, G; Ferlin, G; Pedrazzoli, Sergio

doi:10.1097/00000658-200111000-00014

Cited by 113 publications

(50 citation statements)

References 31 publications

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“…If malignancy is suspected, bone biopsy has to be performed. FDG-PET and FDG-PET/CT are increasingly used for the differentiation of malignant and benign tumors in many organ systems (1)(2)(3)(4)(5). However, the role of PET/(CT) in the evaluation of bone tumors is not well defined, yet (6,7).…”

Section: Introductionmentioning

confidence: 99%

The additional value of CT images interpretation in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT

Strobel

Exner

Stumpe

et al. 2008

Eur J Nucl Med Mol Imaging

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OBJECTIVE: To evaluate the value of a dedicated interpretation of the CT images in the differential diagnosis of benign vs. malignant primary bone lesions with 18 fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT). MATERIALS AND METHODS: In 50 consecutive patients (21 women, 29 men, mean age 36.9, age range 11-72) with suspected primary bone neoplasm conventional radiographs and 18F-FDG-PET/CT were performed. Differentiation of benign and malignant lesions was separately performed on conventional radiographs, PET alone (PET), and PET/CT with specific evaluation of the CT part. Histology served as the standard of reference in 46 cases, clinical, and imaging follow-up in four cases. RESULTS: According to the standard of reference, conventional 17 lesions were benign and 33 malignant. Sensitivity, specificity, and accuracy in assessment of malignancy was 85%, 65% and 78% for conventional radiographs, 85%, 35% and 68% for PET alone and 91%, 77% and 86% for combined PET/CT. Median SUV(max) was 3.5 for benign lesions (range 1.6-8.0) and 5.7 (range 0.8-41.7) for malignant lesions. In eight patients with bone lesions with high FDG-uptake (SUV(max) >or= 2.5) dedicated CT interpretation led to the correct diagnosis of a benign lesion (three fibrous dysplasias, two osteomyelitis, one aneurysmatic bone cyst, one fibrous cortical defect, 1 phosphaturic mesenchymal tumor). In four patients with lesions with low FDG-uptake (SUV(max) < 2.5) dedicated CT interpretation led to the correct diagnosis of a malignant lesion (three chondrosarcomas and one leiomyosarcoma). Combined PET/CT was significantly more accurate in the differentiation of benign and malignant lesions than PET alone (p = .039). There was no significant difference between PET/CT and conventional radiographs (p = .625). CONCLUSION: Dedicated interpretation of the CT part significantly improved the performance of FDG-PET/CT in differentiation of benign and malignant primary bone lesions compared to PET alone. PET/CT more commonly differentiated benign from malignant primary bone lesions compared with conventional radiographs, but this difference was not significant. The Additional Value of CT Images Interpretation in the Differential Diagnosis of Benign vs. Malignant Primary Bone Lesions with 18F- FDG-PET/CT Abstract ObjectiveTo evaluate the value of a dedicated interpretation of the CT images in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT. MethodsIn 50 consecutive patients (21 female, 29 male, mean age 36.9, age range 11 -72) with suspected primary bone neoplasm conventional radiographs and 18F-FDG-PET/CT were performed. Differentiation of benign and malignant lesions was separately performed on conventional radiographs, PET alone (PET) and PET/CT with specific evaluation of the CT part. Histology served as the standard of reference in 46 cases, clinical and imaging follow-up in four cases. ResultsAccording to the standard of reference conventional 17 lesions were benign and...

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Section: Introductionmentioning

confidence: 99%

The additional value of CT images interpretation in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT

Strobel

Exner

Stumpe

et al. 2008

Eur J Nucl Med Mol Imaging

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“…Several studies have investigated the outcomes in IPMN cases, concluding that dual-phase F-18 fluorodeoxyglucose positron emission tomography withcomputedtomography(FDG-PET/CT)hasanoverallspecificityof92-95%andasensi-tivityof88-94%whentryingtodifferentiatemalignantIPMNsvs.benignlesions.Ithasbeen proposedthatPETscansshouldbeperformedinolderpatients,casesatincreasedsurgical risk,orwhenthefeasibilityofparenchyma-sparingsurgerydemandsareliablepreoperative exclusion of malignancy [41,42].…”

Section: Pet Scanmentioning

confidence: 99%

Intraductal Papillary Mucinous Neoplasms of the Pancreas: Challenges and New Insights

Carroll¹,

Reyes²,

Vázquez³

2017

Challenges in Pancreatic Pathology

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Cystic lesions of the pancreas are a common entity with almost a 25% incidence of the general population. These types of lesions are being increasingly diagnosed partly explained due to the technological advances over the past years. The management and treatment varies per cyst type. However, the most threatening cyst lesions are intraductal papillary mucinous neoplasms (IPMNs). These lesions represent nowadays a relatively new clinical entity and in many aspects remain poorly understood. The aim of this chapteristoprovideacomprehensivereviewoftheclassification,diagnosis,treatment and follow-up strategy.

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“…A positive result on FDG-PET strongly suggests malignancy and, therefore, a need for resection. A negative result shows a benign tumor that may be treated with limited resection or, in selected high-risk patients, with biopsy, follow-up, or both (Sperti et al, 2001;Mansour et al, 2006).…”

Section: Fluorodeoxyglucose Positron Emission Tomography (Fdg-pet)/comentioning

confidence: 99%

Pancreatic cystic neoplasms: a review of preoperative diagnosis and management

Bai

Zhang

Masood

et al. 2013

J. Zhejiang Univ. Sci. B

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Pancreatic cystic neoplasms (PCNs) are a diverse group of neoplasms in the pancreas, and are more increasingly encountered with widespread abdominal screening and improved imaging techniques. The most common types of PCNs are serous cystic neoplasms (SCNs), mucinous cystic neoplasms (MCNs), and intraductal papillary mucinous neoplasms (IPMNs). Clinicians frequently feel bewildered in the differential diagnosis and subsequent management among the various types of lesions in the pancreas, which may lead to overtreatment or delayed treatment. The current review provides recent developments in the understanding of the three most common types of PCNs, the latest modalities used in preoperative diagnosis and differential diagnosis, as well as the most up to date management. Suggestions for diagnosis and differential diagnosis of SCNs, MCNs, and IPMNs are also provided for young surgeons. Better understanding of these neoplasms is essential for clinicians to make accurate diagnosis and to provide the best management for patients.

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Value of 18-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients With Cystic Tumors of the Pancreas

Cited by 113 publications

References 31 publications

The additional value of CT images interpretation in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT

The additional value of CT images interpretation in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT

Intraductal Papillary Mucinous Neoplasms of the Pancreas: Challenges and New Insights

Pancreatic cystic neoplasms: a review of preoperative diagnosis and management

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