Value of a testicular biopsy rating for prognosis in oligozoospermia.

Abstract

289feelings, not only through social conditioning but also because these feelings are unpleasant. In some cases these "bad" feelings have been inadequately dealt with and cause trouble. Dynamic psychiatry brings out the long-forgotten impulses and experiences underlying a patient's disturbance and makes them available for examination. It might then be possible to resolve the unconscious conflicts and problems, or at least put them away more effectively.Dynamic psychiatry is difficult for both the patient and the worker. For the patient, at first, it seems as if life is being made even more difficult; he is being forced into owning unpleasant -perhaps frightening-feelings, the very thing he has been trying to avoid and hopes to escape from by coming for treatment.For the worker, to grasp and hold on to the value of the concepts used in dynamic work-something that goes so much against his natural tendency-is not easy. To-be touched emotionally by the disturbance of the patient makes him anxious and insecure. It is most difficult for the doctor. Doctors have had a specialised training in treatment based on antidynamic principles in which they have developed confidence over the years. They have also developed a feeling of security and an uncomfortable yet satisfying feeling of near omnipotence as a result of projections on to them from lay people. It is with the greatest difficulty that they abandon the security of these attitudes in the face of all the internal and external forces that work towards their retaining them.Ever since mental illnesses began to be regarded as amenable to treatment attempts have been made to classify them on some rational basis so that treatment could be administered in a simple, logical manner in accordance with such classifications. While efforts at classification continue, I believe that the human mind is increasingly recognised to be too complex and subject to too many variables to permit a simple medical model of mental illness. This is true of adolescent psychiatry more than any other branch of psychiatry.'Any rational and serious attempt to treat adolescent problems must take the causative factors into account. Usually these result from the adolescents' relationships with significant people in their lives. Treatment must take these factors into account and therefore must be on dynamic lines. ReferencesWorld Health Organisation, Glossary of Mental Disorders and Guide to their Classification. Geneva, WHO, 1974. Clinical TopicsValue of a testicular biopsy rating for prognosis in oligozoospermia J H AAFJES, J C M VAN DER VIJVER, P E SCHENCK British Medical Journal, 1978, 1, 289-290 Summary and conclusions Testicular biopsies of 142 oligozoospermic men were used to obtain a testicular biopsy score count. These scores were clearly related to the chance of fertility, in contradistinction to data on hormone concentrations and from analysis of semen. In 36 patients with a score of 9-10 there were 15 pregnancies; in 59 patients with a score of 8-9, 12; and in 47 patients with scores be...

Identification of human spermatogenesis-related proteins by comparative proteomic analysis: a preliminary study

“…Each tissue sample was divided immediately on ice into two parts, which were either fixed in Bouin's solution for histological examination or snap-frozen in liquid nitrogen for protein extraction. Biopsy specimens were assessed according to a modified Johnsen score (9) as modified by Aafjes et al (10). Seminiferous tubule cross-sections were rated with a score of 1 to 10 according to the most advanced stage of spermatogenesis observed.…”

Ethylene Dichloride Disruption of Fertility in Male Mice

“…As indicators of testicular pathology, histologic preparations from mouse testes were examined for Leydig cell counts, percentage of seminiferous tubules that are SCO, and scored based on spermatogenic activity [17,18]. Analyses of testicular tissue from all of the mice treated with EDC displayed numerous Leydig cells in the intertubular interstitial spaces.…”

“…However, the random evaluation of twenty seminiferous tubules per histological testicular cross-section should normalize these species differences and provide an appropriate scoring system to compare changes in testicular functions. Using the criteria of Johnsen [17] as modified by Aafjes et al [18], hematoxylan and eosin stained sections of paraffin embedded, formalin fixed testis were scored on a 10 point scale assessing the extent of spermatogenesis. Twenty randomly chosen seminiferous tubules were evaluated utilizing the testicular scoring protocol below: …”

Can inhibin-B predict the outcome of microsurgical epididymal sperm aspiration in patients with suspected primary obstructive azoospermia?

“…Diagnostic testicular biopsies were taken in 37 patients, either as a separate diagnostic procedure or as the scrotal exploration. Biopsy specimens were scored using the method described by Johnsen [19], modified by Aafjes et al [20]. Using the modified Johnsen score, seminiferous tubule cross-sections were rated with a score from 1 to 10, based on the most advanced stage of spermatogenesis observed.…”