Value of Acute&amp;ndash;Phase Proteins in the Differential Diagnosis of Acute Scrotum

Doehn, Christian; Fornara, Paolo; Kausch, Ingo; Büttner, H.; Friedrich, H.; Jocham, Dieter

doi:10.1159/000052439

Cited by 17 publications

(12 citation statements)

References 14 publications

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“…There were significant differences in CRP after surgery among the groups; as expected, TP resulted in the highest CRP. Fornar et al [13] compared laparoscopic and classical open surgery, concluding that surgical trauma could be measured by laboratory tests such as CRP.…”

Section: Discussionmentioning

confidence: 99%

Systemic stress responses in patients undergoing surgery for benign prostatic hyperplasia

Ružić¹,

Tomašković²,

Trnski³

et al. 2004

BJU International

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and group 3, prostate > 80 g, treated with a suprapubic transvesical prostatectomy (TP). Blood samples were taken from each patient on the day before and the day after surgery, and the acute-phase reactants and antioxidants measured; cortisol concentrations were also measured in 24-h urine samples the day before and 3 days after surgery. RESULTSThere were significantly higher levels of cortisol, CRP and TAS, and significantly lower levels of fibrinogen and SOD in all study groups after surgery than before. Surgery and associated conditions, e.g. excitement, fear, blood loss, etc., lead to traumatic and oxidative stress, followed by a strong systemic stress response during and after surgery. Low fibrinogen levels after surgery had a different pattern from the other acute-phase reactants, as a result of increased fibrinolytic activity after TURP and TP. CONCLUSION

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Section: Discussionmentioning

confidence: 99%

Systemic stress responses in patients undergoing surgery for benign prostatic hyperplasia

Ružić¹,

Tomašković²,

Trnski³

et al. 2004

BJU International

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“…91 A study of testicular cancer reported CRP to be highly sensitive and specific in differentiating epididymitis (in which the CRP concentrations were higher than in the malignant disease) from cancer. 57 Thus, the results from the studies that presented appropriate tests of diagnostic accuracy did not provide strong evidence to support the usefulness of increased CRP in early diagnosis of cancer. However, most studies claiming to examine the role of CRP in the diagnosis of cancer did not undertake appropriate analyses (sensitivity, specificity, receiver operator characteristics or other tests of calibration or discrimination) to determine the usefulness of CRP as a diagnostic tool in cancer.…”

Section: Adjustment For Confoundersmentioning

confidence: 92%

A systematic review of the association between circulating concentrations of C reactive protein and cancer

Heikkilä

Ebrahim

Lawlor

2007

Journal of Epidemiology & Community Health

356

267

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The objective of this study was to review and summarise the published evidence for an association between circulating concentrations of C reactive protein (CRP) and cancer through a systematic review. 90 discrete studies were identified. 81 (90%) were prevalent case-control or cross-sectional studies, and only 9 studies had a prospective design. In most prevalent studies, CRP concentrations were found to be higher in patients with cancer than in healthy controls or controls with benign conditions. Of the nine large prospective studies identified in this review, four reported no relationship between circulating CRP levels and breast, prostate or colorectal cancers, and five studies found that CRP was associated with colorectal or lung cancers. Most of the studies evaluating CRP as a diagnostic marker of cancer did not present relevant statistical analyses. Furthermore, any association reported in the prevalent studies might reflect reverse causation, survival bias or confounding. The prospective studies provided no strong evidence for a causal role of CRP in cancer. Instead of further prevalent studies, more large prospective studies and CRP gene-cancer association studies would be valuable in investigating the role of CRP in cancer.

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“…There is a high value of CRP in the condition of an inflammatory disorders lead of acute scrotum (Asgari et al, 2006;Doehn et al, 2001). CRP finding is speedily and readily approachable for analysis, which is very essential, as an inessential waste of time in finding the right cause can be withering in the condition of a child's testis (Meštrović et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…This may help early diagnosis; however, the value of these nonspecific inflammatory parameters has not been elucidated yet. In a retrospective study on 104 patients with acute scrotum, it was shown that serum level of C-reactive protein (CRP) is an assistant in discriminating epididymitis from noninflammatory circumstances resembling spermatic cord torsion or neoplasm (Asgari et al, 2006;Doehn et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

Role of Doppler Ultrasonography and C-Reactive Protein in Patients with Acute Scrotum

Mohammed¹,

Elkhader²,

Saade³

et al. 2016

GJHS

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This research was designate with an intention to find the role of Doppler ultrasonography (DUS) and C-reactive protein (CRP) in patients with acute scrotum. A sum of 80 (mean age 23±2.1 years) consequential patients were recruited for a period of six months between July 2015 and January 2016 in this prospective study. Collected data confined age, medical history, and clinical symptoms. DUS was performed with a linear array transducer (10-15 MHz) connected to HI vision Avius ultrasound unit; Hitachi. CRP was measured using turbidimetric analysis through the Cobas Integra analyzer system (Test CRPL2, 0-293); Roche Diagnostics. Statistical analysis was accomplished using the standard Statistical Package for the Social Sciences version 20 for Windows; Microsoft. Fitted achievement values for DUS in the diagnosis of testicular torsion, epididymo-orchitis, and varicocele were respectively 100%, 91% and 88% for sensitivity, 92%, 71%, and 90% for specificity, and 94%, 83%, and 89% for accuracy. An increased in the serum CRP level (63.2±40.2 mg/L) was seen in an inflammatory cause of the acute scrotum. In contrast, there was no increase in CRP level (8±3.1 mg/L) in the non-inflammatory cases (P < 0.0001). Scrotal DUS is a highly precise preoperative diagnostic instrument, thereby confirm its course application in the incipient triage of patients with acute scrotum. Serum level of CRP can afford useful advice for differentiation between inflammatory and other reasons of the acute scrotum.

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Value of Acute–Phase Proteins in the Differential Diagnosis of Acute Scrotum

Cited by 17 publications

References 14 publications

Systemic stress responses in patients undergoing surgery for benign prostatic hyperplasia

Systemic stress responses in patients undergoing surgery for benign prostatic hyperplasia

A systematic review of the association between circulating concentrations of C reactive protein and cancer

Role of Doppler Ultrasonography and C-Reactive Protein in Patients with Acute Scrotum

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