Value of adipokines in predicting the severity of acute pancreatitis: Comprehensive review

Karpavičius, Andrius; Dambrauskas, Žilvinas; Šileikis, Audrius; Vitkus, Dalius; Strupas, Kęstutis

doi:10.3748/wjg.v18.i45.6620

Cited by 35 publications

(24 citation statements)

References 39 publications

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“…Resistin and visfatin were found to be good predictors of pancreatic necrosis with cut-off levels of 11.9 ng/mL and 1.8 ng/mL, respectively. However, Al-Maramhy et al did not find resistin as a useful marker for predicting severity [ 106 , 107 ].…”

Section: Biomarkers Of Pancreatic Necrosismentioning

confidence: 99%

Role of Biomarkers in Diagnosis and Prognostic Evaluation of Acute Pancreatitis

Meher

Mishra

Sasmal

et al. 2015

Journal of Biomarkers

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Acute pancreatitis is a potentially life threatening disease. The spectrum of severity of the illness ranges from mild self-limiting disease to a highly fatal severe necrotizing pancreatitis. Despite intensive research and improved patient care, overall mortality still remains high, reaching up to 30–40% in cases with infected pancreatic necrosis. Although little is known about the exact pathogenesis, it has been widely accepted that premature activation of digestive enzymes within the pancreatic acinar cell is the trigger that leads to autodigestion of pancreatic tissue which is followed by infiltration and activation of leukocytes. Extensive research has been done over the past few decades regarding their role in diagnosis and prognostic evaluation of severe acute pancreatitis. Although many standalone biochemical markers have been studied for early assessment of severity, C-reactive protein still remains the most frequently used along with Interleukin-6. In this review we have discussed briefly the pathogenesis and the role of different biochemical markers in the diagnosis and severity evaluation in acute pancreatitis.

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Section: Biomarkers Of Pancreatic Necrosismentioning

confidence: 99%

Role of Biomarkers in Diagnosis and Prognostic Evaluation of Acute Pancreatitis

Meher

Mishra

Sasmal

et al. 2015

Journal of Biomarkers

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“…These results suggest that the increased leptin concentration in diabetic dogs might have been caused by concurrent diseases, instead of being a direct effect of hyperglycemia due to DM. Previous studies have also provided evidence of the dysregulation of serum leptin concentrations by other specific diseases [ 3 6 17 ]. A recent study of dogs with pituitary-dependent hyperadrenocorticism suggested that higher circulating leptin concentrations might be associated with hypercortisolemia [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recent study of dogs with pituitary-dependent hyperadrenocorticism suggested that higher circulating leptin concentrations might be associated with hypercortisolemia [ 6 ]. In humans, several studies have shown that leptin concentrations were higher in patients with acute pancreatitis [ 17 ] and chronic kidney disease [ 3 ]. In the present study, AP (8/11, 72.7%), HAC (5/11, 45.5%), and CKD (5/11, 45.5%) were confirmed as concurrent disorders in diabetic dogs.…”

Section: Discussionmentioning

confidence: 99%

Serum adipokine concentrations in dogs with diabetes mellitus: a pilot study

Kim

Kang

et al. 2015

J Vet Sci

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This study was conducted to determine whether serum adipokine concentrations differed between healthy dogs and dogs with diabetes mellitus (DM). To accomplish this, 19 dogs with newly diagnosed DM were compared to 20 otherwise healthy dogs. The serum concentrations of visfatin, leptin, IL-1β, IL-6, IL-18, and TNF-α were significantly higher in diabetic dogs than in healthy dogs, whereas the serum adiponectin concentrations were lower in diabetic dogs. However, there were no significant differences in the IL-10 and resistin levels between groups. The serum leptin concentrations in diabetic dogs with and without concurrent disorders differed significantly. Treatment with insulin induced a significant decrease in IL-6 in diabetic dogs without concurrent disorders. These results show that the clinical diabetic state of dogs could modulate the circulating visfatin and adiponectin concentrations directly, while upregulation of leptin was probably a result of concurrent disorders rather than an effect of persistent hyperglycemia as a result of DM.

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“…Fat necrosis promotes high level infiltration of leukocytes into damaged areas of adipose tissue, and adipocytes, adipose tissue macrophages, and recruited immune cells become sources of inflammatory cytokines . In human medicine, it has been suggested that increases in the levels of circulating adipokines, especially resistin and visfatin, could be used as specific markers for peripancreatic fat necrosis . However, little information is available about the circulating adipokine concentrations during the pathogenesis of AP in dogs.…”

mentioning

confidence: 99%

“…11 In human medicine, it has been suggested that increases in the levels of circulating adipokines, especially resistin and visfatin, could be used as specific markers for peripancreatic fat necrosis. 12,13 However, little information is available about the circulating adipokine concentrations during the pathogenesis of AP in dogs. In our preliminary study, we measured the adipokine concentrations in dogs with AP, a but the group sizes were small and it was difficult to reach any firm conclusions about the roles of adipokines during the development of AP in dogs.…”

mentioning

confidence: 99%

Serum Adipokine Concentrations in Dogs with Acute Pancreatitis

Paek

Kang

Kim

et al. 2014

Veterinary Internal Medicne

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BackgroundLimited information is available about the role of adipokines in the development and progression of acute pancreatitis (AP) in dogs.ObjectivesTo determine whether the circulating concentrations of adipokines differed between healthy dogs and dogs with AP, and whether the circulating concentrations differed between AP survivors and AP nonsurvivors.AnimalsTwenty‐eight healthy dogs and 25 client‐owned dogs with AP.MethodsProspective observational cohort study of 25 client‐owned dogs with newly diagnosed AP and 28 otherwise healthy dogs with similar body condition scores. The serum concentrations of leptin, adiponectin, resistin, visfatin, interleukin (IL)‐1β, IL‐6, IL‐10, IL‐18, and tumor necrosis factor (TNF)‐α were measured.ResultsThe serum concentrations of leptin (P = .0021), resistin (P = .0010), visfatin (P < .0001), IL‐1β (P < .0001), IL‐6 (P = .0002), IL‐10 (P < .0001), and IL‐18 (P < .0001) were significantly higher in dogs with AP than healthy dogs, whereas the adiponectin concentration (P = .0011) was significantly lower. There were significant differences in the serum concentrations of leptin (P = .028) and adiponectin (P = .046) in survivors and nonsurvivors. After the disappearance of clinical signs, the concentrations of resistin (P = .037) and IL‐1β (P = .027) decreased significantly, whereas the serum concentrations of leptin (P > .999), adiponectin (P = .11), visfatin (P = .83), IL‐6 (P = .82), IL‐10 (P = .82), IL‐18 (P = .56), and TNF‐α (P = .94) did not differ significantly.Conclusion and Clinical ImportanceThis study showed that dysregulation of adipokines might be involved in the pathogenesis of AP. In addition, leptin and adiponectin are likely to be associated with mortality rate in AP.

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Value of adipokines in predicting the severity of acute pancreatitis: Comprehensive review

Abstract: High levels of adipokines could allow for prediction of a severe disease course and outcome even in small pancreatic lesions on computed tomography scans.

Cited by 35 publications

References 39 publications

Role of Biomarkers in Diagnosis and Prognostic Evaluation of Acute Pancreatitis

Role of Biomarkers in Diagnosis and Prognostic Evaluation of Acute Pancreatitis

Serum adipokine concentrations in dogs with diabetes mellitus: a pilot study

Serum Adipokine Concentrations in Dogs with Acute Pancreatitis

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