Value of antenatal diagnosis of abnormalities of the urinary tract.

Greig, JM; Raine, P.A.M.; Young, D.G.; Azmy, Amir; Mackenzie, James; Danskin, F.; Whittle, M. J.; McNay, Margaret B.

doi:10.1136/bmj.298.6685.1417

Cited by 31 publications

(4 citation statements)

References 8 publications

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“…In fact starting from 1984, we observed a progressive increase in the reports of UTA in our Registry, through prenatal diagnosis that increased to 60% of all cases of UTA in the last year of the study. This observation is similar to others in literature [19][20][21][22][23]. Otherwise UTA associated with other unrelated defects shows a stability in time, as shown by the very low correlation coefficient (r = 0.09).…”

Section: Discussionsupporting

confidence: 77%

Urinary tract abnormalities (UTA) and associated malformations: Data of the Emilia-Romagna Registry

et al. 1996

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An epidemiological study on the urinary tract anomalies (UTA) associated with other congenital malformations or syndromes ascertained by the Emilia-Romagna Registry on Congenital Malformations (IMER) among 209,882 consecutive births monitored during the period 1981-1990 is presented. UTA were ascertained in 349 infants for a rate at birth of 16.6 per 10,000 total births, or one case for every 600 births. The occurrence rate of UTA increased significantly during the ten years of monitoring passing from 6.1 per 10,000 in 1981-1982 to 25.1 in 1989-1990 (r = 0.85; p < 0.001). This increase is in connection with a progressively higher notification of isolated cases of UTA, directly related to the impact of the prenatal diagnosis. Among the 349 cases, 106 (30.4%) were associated with other conditions, including 18 who had chromosomal aberrations (ChrA). The incidence in the total number of the ChrA registered was 43.6 per 1,000. Genetic syndromes (GS) in 33 cases with a specific rate of 150 per 1,000, and 55 cases of multiples with a specific rate of 205.2 per 1,000. In multiples we observed some preferential associations of UTA with intestinal defects and severe ear defects (p < 0.001) and for Central Nervous System and heart defects (p < 0.05). UTA are often associated with other extrarenal defects and sometimes are a component of syndromes that are difficult to identify and for which genetic implications are great and genetic counselling necessary. Pediatricians need to be aware of the possible involvement of the kidney in specific and rare syndromes, and pediatric nephrologists must recognize the association of renal diseases with abnormalities in other physiological systems.

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Section: Discussionsupporting

confidence: 77%

Urinary tract abnormalities (UTA) and associated malformations: Data of the Emilia-Romagna Registry

et al. 1996

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“…However, our inci dence of 18.9°/oo is similar to the postnatal ultrasound screening incidence reported by Riccipctitoni et al [ 11 ]. Our diagnosis accura cy is higher than the 50.1-81.5% reported pre viously [3,10,[12][13][14], But the positive predic tive value definition changes with these differ ent studies. Our high rate also reflects im provements in scanning equipment and exper tise by obstetricians, who now have a better experience of fetal uropathies.…”

Section: Discussioncontrasting

confidence: 54%

Outcome of Urological Abnormalities Prenatally Diagnosed by Ultrasound

Podevin¹,

Mandelbrot²,

Vuillard³

et al. 1996

Fetal Diagn Ther

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In order to evaluate the efficiency of antenatal diagnosis and postnatal management of urinary malformations, we reviewed 142 cases from October 1988 to December 1992 with abnormalities detected by routine ultrasound. A routine karyotype analysis showed 7 fetuses with chromosomal defects. Nine cases with isolated bilateral urinary tract dilatation underwent pelvic fetal urine sampling in order to assess antenatal renal function. The 142 cases comprised 107 children born alive (group I) and 35 intrauterine fetal deaths (group II). In group I, 79 kidneys had a transient pyelectasis, and 11 kidneys had a hydronephrosis which disappeared at postnatal examination. Among 103 pyelectasis cases detected during the second trimester of pregnancy, 22 kidneys were pathological after birth (positive predictive value (PPV) = 21.4%) with 17 ureteropelvic junction obstructions. The PPV was 66% when ultrasound showed hydronephrosis at the end of pregnancy. In that group, 15 cases had vesicoureteric reflux, with 5 cases where the homolateral upper urinary tract was morphologically normal in utero. Group II comprised 27 fetuses with multiple defects in other systems, and 8 cases with urological defects only 7 of which had urethral anomalies. This study confirmed the benefit of antenatal diagnosis for uropathies, and the advantage of prenatal consultation between pediatric surgeon and parents in order to explain what anomalies are involved and to program postnatal follow-up.

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“…Their incidence varies from 0.1% to 1% of all pregnancies. Uropathies correspond to 30-50% of all structural abnormalities found at birth [1][2][3]. The spectrum of malformations is wide, and their prognosis is significantly poorer in fetuses with bilateral lesions and decreased volume of amniotic fluid.…”

mentioning

confidence: 99%

Complementary Role of MRI After Sonography in Assessing Bilateral Urinary Tract Anomalies in the Fetus

Cassart

Massez

Metens

et al. 2004

American Journal of Roentgenology

146

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Value of antenatal diagnosis of abnormalities of the urinary tract.

Abstract: Objective-To assess the value of antenatal diagnosis of abnormalities of the urinary tract on ultrasonography.Design-Retrospective study.

Cited by 31 publications

References 8 publications

Urinary tract abnormalities (UTA) and associated malformations: Data of the Emilia-Romagna Registry

Urinary tract abnormalities (UTA) and associated malformations: Data of the Emilia-Romagna Registry

Outcome of Urological Abnormalities Prenatally Diagnosed by Ultrasound

Complementary Role of MRI After Sonography in Assessing Bilateral Urinary Tract Anomalies in the Fetus

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