Value of CRP, PCT, and NLR in Prediction of Severity and Prognosis of Patients With Bloodstream Infections and Sepsis

Abstract

ObjectiveTo investigate the value of C-reactive protein (CRP), procalcitonin (PCT), and neutrophil to lymphocyte ratio (NLR) in assessing the severity of disease in patients with bloodstream infection and sepsis, and to analyze the relationship between the levels of three inflammatory factors and the prognosis of patients.MethodsThe clinical data of 146 patients with bloodstream infection and sepsis admitted to our intensive care unit (ICU) from October 2016 to May 2020 were retrospectively analyzed. The differences in the levels of inflammatory indicators such as CRP, PCT, and NLR within 24 h in patients with bloodstream infection sepsis with different conditions (critical group, non-critical group) and the correlation between these factors and the condition (acute physiology and chronic health evaluation II, APACHE II score) were analyzed. In addition, the prognosis of all patients within 28 days was counted, and the patients were divided into death and survival groups according to their mortality, and the risk factors affecting their death were analyzed by logistic regression, and the receiver operating characteristic (ROC) curve was used to analyze the value of the relevant indicators in assessing the prognosis of patients.ResultsThe levels of NLR, CRP, PCT, total bilirubin (TBIL), glutamic oxaloacetic transaminase (AST), and serum creatinine (Scr) were significantly higher in the critically ill group than in the non-critically ill group, where correlation analysis revealed a positive correlation between CRP, PCT, and NLR and APACHE II scores (P < 0.05). Univariate logistic regression analysis revealed that CRP, PCT, NLR, and APACHE II scores were associated with patient prognosis (P < 0.05). Multi-factor logistic regression analysis found that PCT, NLR, and APACHE II scores were independent risk factors for patient mortality within 28 days (P < 0.05). ROC curve analysis found that PCT and NLR both had an AUC area > 0.7 in predicting patient death within 28 days (P < 0.05).ConclusionInflammatory factors such as NLR, CRP, and PCT have important clinical applications in the assessment of the extent of disease and prognosis of patients with bloodstream infection and sepsis.

High level of neutrophil to lymphocyte ratio increases the risk of deep venous thrombosis in intensive care unit patients after oral cancer surgery: a retrospective study

“…Another study (28) indicated that NLR is increased in sepsis patients and is significantly correlated with sepsis severity evaluated by the sequential organ failure assessment (SOFA) score. The same study (28) indicated that NLR plays a role in prediction of severity and prognosis of patients with bloodstream infections (29) and is also predictive of a worse outcome of severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in frequent exacerbators with a cutoff value of 10.23 (30). In our study, we discovered that compared with the non-DVT group, the MVT and LOS were longer in the DVT group, moreover, the NLR level was positively related with MVT (r=0.36; P<0.001) and LOS (r=0.452; P<0.0001).…”

Roles of NLR and percentage of neutrophils in assessing the prognosis of sepsis: a single-center retrospective study

“…NLR is a cheap, simple, rapid and easily available in ammation-related parameter. It has been con rmed that NLR had a high sensitivity for the diagnosis and strati cation of sepsis with a good predictive and prognostic value in sepsis [33][34][35].…”

Hydrogen Sulfide and Substance P Levels in Patients with Escherichia coli and Klebsiella pneumoniae Bacteraemia

“…C-reactive protein levels have been of great clinical interest for early diagnosis of infection and monitoring its treatment response as they are easily measured and related to the severity of the systemic inflammatory response [ 33 , 34 , 35 , 36 , 37 ]. The results of the present study show a higher plasma concentration of CRP, peaking on day 1, but there was no significant correlation between the H 2 S and SP concentrations in either the urinary tract infection or abdominal infection group, although this may become apparent in a larger cohort.…”