Value of evaluating procalcitonin kinetics in diagnosis of infections in patients undergoing laparoscopic radical cystectomy

Ding, Xiangli; Yang, Delin; Ke, Changxing; Gong, Likun; Zhan, Hui; Yan, Ruping; Chen, Yan; Li, Haiyuan; Wang, Jiansong

doi:10.1097/md.0000000000008152

Cited by 3 publications

(1 citation statement)

References 44 publications

(41 reference statements)

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“…CRP and PCT have been recognized in the diagnosis of infectious diseases [15,16,17]. Serum PCT, as a new bacterial infection marker, is often widely used in the diagnosis of infectious diseases.…”

Section: Comparison Of P38 Mapk Protein Expression In Lung Tissue Of ...mentioning

confidence: 99%

Effect of Chalcone on Inflammatory Factors and the Expression of P38 Mapk Protein in Streptococcus Pneumoniae Mice

Luo¹

2023

FARMACIA

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The effects of chalcone on inflammatory response and expression of mitogen-activated protein kinase p38 (p38 MAPK) in lung tissue of mice with pneumonia due to Streptococcus pneumoniae were investigated. Sixty male Kunming mice were divided into three groups (20 mice in each group), a control group, a pneumonia model group and a chalcone group. For the mice in model group and chalcone group, Streptococcus pneumoniae standard strain solution was used for modelling, while the control group was slowly dripped with 50 μL normal saline solution. After successful modelling, mice in the chalcone group were subcutaneously injected with 100 mg/kg chalcone, and mice in the model group and control group were subcutaneously injected with an equal volume of normal saline solution, once every 8h, for 3 days. Venous blood was collected to determine C-reactive protein (CRP) and procalcitonin (PCT) levels. Inflammatory markers were also detected in lung tissue. The results showed that in the pneumonia group there is a significant increase in CRP, PCT, IL-1β, TNF-α, IL-6 and IL-8 levels, along with increased expression of the p38 MAPK gene and protein compared to the control group. Chalcone treatment can significantly reduce the level of inflammatory factors in the lung tissue of mice with pneumonia and down-regulate the expression of p38 MAPK gene and protein. Therefore, this may be one of the mechanisms by which chalcone inhibits the inflammatory response of lung tissue in mice with Streptococcus pneumoniae pneumonia. RezumatAu fost investigate efectele calconei asupra răspunsului inflamator și a expresiei genei și proteinei p38 MAPK în țesutul pulmonar la șoarecii cu pneumonie indusă cu Streptococcus pneumoniae. Șaizeci de șoareci Kunming masculi au fost împărțiți egal în trei grupuri astfel: un grup martor, un grup control și un grup test. Grupului control și grupului test le-a fost indusă pneumonie, folosind tulpină standard de Streptococcus pneumoniae, în timp ce grupul martor a fost tratat cu 50 μL de souție salină normală. După ce a fost indusă pneumonia, șoarecilor din grupul test le-a fost administră 100 mg/kg de calconă, iar șoarecii din celelalte două grupuri au primit un volum egal de soluție salină normală, o dată la fiecare 8 ore, timp de 3 zile. S-a recoltat sânge venos pentru a se determina nivelurile de proteină C-reactivă (PCR) și procalcitonină (PCT). Totodată, markerii inflamatori au fost detectați la nivelul țesutului pulmonar. Rezultatele arată că în grupul cu pneumonie se observă o creștere semnificativă a nivelurilor de PCR, PCT, IL-1β, TNF-α, IL-6 și IL-8, împreună cu creșterea expresiei genei și a proteinei p38 MAPK, în comparație cu grupul martor. Tratamentul cu calconă poate reduce în mod semnificativ nivelul factorilor inflamatori în țesutul pulmonar la șoarecii cu pneumonie și poate scădea expresia genei și a proteinei p38 MAPK. Prin urmare, acesta poate fi unul dintre mecanismele prin care calcona inhibă răspunsul inflamator la nivelul țesutului pulmonar la șoarecii cu pneumonie indusă cu Streptococ...

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Section: Comparison Of P38 Mapk Protein Expression In Lung Tissue Of ...mentioning

confidence: 99%

Effect of Chalcone on Inflammatory Factors and the Expression of P38 Mapk Protein in Streptococcus Pneumoniae Mice

Luo¹

2023

FARMACIA

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The initial resuscitation of septic shock

Cinel

Kasapoğlu

Gül

et al. 2020

Journal of Critical Care

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Procalcitonin and C-Reactive Protein for Bacterial Infection Diagnosis in Elderly Patients After Traumatic Orthopedic Surgery

Villain

Chenevier‐Gobeaux

Cohen-Bittan

et al. 2019

The Journals of Gerontology: Series A

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Background Biomarkers prove valuable for diagnosing postoperative bacterial infection, but data in elderly patients are scarce. Here we analyze how procalcitonin and C-reactive protein (CRP) perform for bacterial infection diagnosis after traumatic orthopedic surgery in elderly patients. Methods We included all patients admitted to our perioperative geriatrics unit after traumatic orthopedic surgery. Patients on antibiotics, presenting preoperative bacterial infection, or without procalcitonin measurement were excluded. Clinical and biological data were collected prospectively. Medical charts were reviewed by three experts blinded to biomarker results to assess bacterial infection diagnosis. Areas under the curve and 90%-specificity thresholds were analyzed for baseline procalcitonin and CRP levels and relative variations. Results Analysis included 229 patients (median age 86 years, hip fracture 83%), of which 40 had bacterial infection (pneumonia [n = 23], urinary tract infection [n = 8]; median delay to onset: 2 days post-admission). For bacterial infection diagnosis, the computed areas under the curve were not significantly different (procalcitonin–baseline 0.64 [95% confidence interval: 0.57–0.70]; procalcitonin–relative variation 0.65 [0.59–0.71]; CRP–baseline 0.68 [0.61–0.74]; CRP–relative variation 0.70 [0.64–0.76]). The 90%-specificity thresholds were 0.75 µg/L for procalcitonin–baseline, +62% for procalcitonin–variation, 222 mg/L for CRP–baseline, +111% for CRP–variation. Conclusions Diagnostic performances of procalcitonin and CRP were not significantly different. Baseline levels and relative variations of these biomarkers showed little diagnostic value after traumatic orthopedic surgery in elderly patients.

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Value of evaluating procalcitonin kinetics in diagnosis of infections in patients undergoing laparoscopic radical cystectomy

Cited by 3 publications

References 44 publications

Effect of Chalcone on Inflammatory Factors and the Expression of P38 Mapk Protein in Streptococcus Pneumoniae Mice

Effect of Chalcone on Inflammatory Factors and the Expression of P38 Mapk Protein in Streptococcus Pneumoniae Mice

The initial resuscitation of septic shock

Procalcitonin and C-Reactive Protein for Bacterial Infection Diagnosis in Elderly Patients After Traumatic Orthopedic Surgery

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