Value of FDG PET in assessment of treatment response and surveillance in head-and-neck cancer patients after intensity modulated radiation treatment: A preliminary report

Yao, Min; Graham, Michael M.; Smith, Russell B.; Dornfeld, Kenneth J.; Skwarchuk, Mark W.; Hoffman, Henry T.; Funk, Gerry F.; Graham, Scott M.; Menda, Yusuf; Buatti, John M.

doi:10.1016/j.ijrobp.2004.05.058

Cited by 85 publications

(54 citation statements)

References 21 publications

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“…9,11 However, the magnitude of the difference between negative and positive scans, even with several false-positive results in the positive group, should be further investigated. PET/CT negativity within 6 months of RT may be used as an early surrogate endpoint for future clinical trials investigating new treatment combinations.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] On the basis of previously published data suggesting that 18 F-fluorodeoxyglucose (FDG)-PET offers a more accurate assessment of therapy response and earlier detection of recurrent disease than conventional imaging, our group instituted a protocol incorporating PET/CT in the follow-up of patients with head and neck cancers in July, 2005. [6][7][8][9][10][11] The goals of this study were 1) to establish the diagnostic accuracy of follow-up PET/CT in the detection of locoregional recurrence, distant metastases, and second primary tumors; and 2) to determine the impact of PET/CT on the prognosis and management of suspected disease recurrence.…”

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confidence: 99%

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The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Kao

Genden

et al. 2009

Cancer

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Nitroxyl radicals were used as functionalizing agents during the free radical postreactor modification process of polyolefins carried out in the melt. The 4‐hydroxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl (HO‐TEMPO) and the 4‐benzoyloxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl (BzO‐TEMPO) free radicals were successfully grafted onto a polyethylene‐based material (ethylene‐co‐1‐octene copolymer) by coupling reaction with polymer macroradicals; these last were formed by H‐abstraction through peroxide addition. The macromolecular structure of the functionalized polyolefins was assessed by 1H‐NMR, FTIR spectroscopy, and SEC measurements which were used to evidence the grafting site, to evaluate the grafting level and to highlight the occurrence of chain extension through crosslinking side reactions. Indeed the use of proper model compounds allowed the preparation of accurate FTIR calibration curves for the quantitative determination of the functionalization degree. Besides the high temperature SEC analysis highlighted that this fast and simple coupling reaction between macroradicals and nitroxyl free radicals grants the grafting of functionalities onto the polyolefin backbone by contemporarily preventing the side reactions liable of the structure and MW modification of the pristine polymer. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Kao

Genden

et al. 2009

Cancer

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“…39,40 Recent reports suggest that 18FDG-PET scan may be useful for selected patients who may benefit from a neck dissection after radiation therapy. Yao et al showed that for patients with residual lymphadenopathy and a negative PET scan at 12 weeks after definitive radiation treatment, neck dissection can be safely withheld, 41 with a negative predictive value of 100% and a positive predictive value of 43%.…”

Section: Discussionmentioning

confidence: 99%

Intensity‐modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma

Huang

Xia

Chuang

et al. 2008

Cancer

125

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BACKGROUND.Treatment outcomes for stage III and IV oropharyngeal carcinoma treated with intensity‐modulated radiotherapy (IMRT) and concurrent chemotherapy without prior surgical resection were reviewed.METHODS.Between April 2000 and September 2004, 71 patients underwent IMRT concurrent with chemotherapy without prior surgical resection for stage III and IV oropharyngeal carcinoma. Chemotherapy was platinum based. The gross tumor volume (GTV) received 70 Gy in 2.12 Gy per fraction. The high‐risk clinical tumor volume (CTV) received 59.4 Gy in 1.80 Gy per fraction, and the low‐risk CTV received 54 Gy in 1.64 Gy per fraction.RESULTS.With a median follow‐up of 33 months, the 3‐year local, regional, and locoregional progression‐free probabilities were 94%, 94%, and 90%, respectively. The 3‐year overall survival estimate was 83%. Locoregional failures occurred in the GTV in 7 patients. Acute grade 3 or 4 toxicity developed in 35 patients. A feeding gastrostomy was placed in 25 patients. Late xerostomia was grade 0 in 16 patients, grade 1 in 31 patients, and grade 2 in 24 patients at last follow‐up. No patients experienced grade 3 or 4 late toxicity, except for 1 who developed osteoradionecrosis of the mandible.CONCLUSIONS.Excellent local and regional control was achieved with IMRT and concurrent chemotherapy without prior surgical resection in the treatment of stage III and IV oropharyngeal carcinoma. Significant sparing of the parotid glands and other critical normal tissues was possible using IMRT with moderate acute toxicities and minimal severe late effects. Cancer 2008. © 2008 American Cancer Society.

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“…Prior studies with fewer patients have shown similar results, with negative predictive values as high as 97%-100%. [10][11][12] Yao et al 10 examined 85 patients who had HNSCC treated with intensitymodulated radiation therapy and had subsequent FDG PET scans in follow-up. Initial scans had negative findings in 64 patients, and of these patients, there was only 1 local recurrence 7 months after the initial study.…”

Section: Discussionmentioning

confidence: 99%

Negative Predictive Value of Surveillance PET/CT in Head and Neck Squamous Cell Cancer

McDermott

Hughes²,

Rath³

et al. 2013

AJNR Am J Neuroradiol

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Value of FDG PET in assessment of treatment response and surveillance in head-and-neck cancer patients after intensity modulated radiation treatment: A preliminary report

Cited by 85 publications

References 21 publications

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Intensity‐modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma

Negative Predictive Value of Surveillance PET/CT in Head and Neck Squamous Cell Cancer

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