Value of fluid‐attenuated inversion recovery MRI data analyzed by the lesion segmentation toolbox in amyotrophic lateral sclerosis

Wirth, A.; Johannesen, Siw; Khomenko, Andrei; Baldaranov, Dobri; Bruun, Tim‐Henrik; Wendl, Christina; Schuierer, Gerhard; Greenlee, Mark W.; Bogdahn, Ulrich

doi:10.1002/jmri.26577

Cited by 10 publications

(14 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous 1.5T-MRI study on a cohort of 24 ALS patients [19], T2-hyperintensities along the CST were more frequently detected in patients with a higher ALSFRS deterioration rate and a significantly shorter disease duration and were found to have mild predictive value for patient survival. FLAIR CST alterations exhibited stronger prognostic value for survival in a recent 1.5 T-MRI study on 28 ALS patients [20]. Our data on a larger sample and using higher magnetic field suggest an even higher prognostic value for changes in CST signal intensity, especially in combination with motor cortex hypointensity.…”

Section: Discussionsupporting

confidence: 47%

Diagnostic and Prognostic Value of Conventional Brain MRI in the Clinical Work-Up of Patients with Amyotrophic Lateral Sclerosis

Rizzo¹,

Marliani

Battaglia

et al. 2020

JCM

View full text Add to dashboard Cite

Clinical signs of upper motor neuron (UMN) involvement are important in the diagnosis of amyotrophic lateral sclerosis (ALS) though are often difficult to analyze. Many studies using both qualitative and quantitative evaluations have reported abnormal Magnetic Resonance Imaging (MRI) findings at the level of the pyramidal pathway in patients with ALS. Although the most interesting results were obtained by quantitative studies using advanced MR techniques, the qualitative evaluation of MRI images remains the most-used in clinical practice. We evaluated the diagnostic and prognostic contribution of conventional 3T-MRI in the clinical work-up of ALS patients. Two neuroradiologists retrospectively assessed 3T-MRI data of 93 ALS patients and 89 controls. The features of interest were corticospinal tract (CST) T2/FLAIR hyperintensity, motor cortex (MC) T2*/SWI hypointensity, and selective MC atrophy. All MRI features were significantly more prevalent in ALS patients than in controls. The simultaneous presence of CST FLAIR hyperintensity and MC SWI hypointensity was associated with the highest diagnostic accuracy (sensitivity: 70%; specificity: 81%; positive predictive value, PPV: 90%; negative predictive value, NPV: 51%; accuracy: 73%) and a shorter survival (HR: 6.56, p = 0.002). Conventional 3T-MRI can be a feasible tool to detect specific qualitative changes based on UMN involvement and to support clinical diagnosis of ALS. Importantly, CST FLAIR hyperintensity and MC SWI hypointensity are predictors of shorter survival in ALS patients.

show abstract

Section: Discussionsupporting

confidence: 47%

Diagnostic and Prognostic Value of Conventional Brain MRI in the Clinical Work-Up of Patients with Amyotrophic Lateral Sclerosis

Rizzo¹,

Marliani

Battaglia

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…A minimum extend threshold was set to 0.01 cm 3 . Lesion probability maps were binarized by applying a threshold of 0.5 [ 35 ], and lesion masks were thereby generated. Lesion masks were visually inspected and corrected for false positives in corticospinal tracts if necessary using a specific corticospinal tract mask for each participant (corticospinal hyperintensities are common artifacts in WMH segmentations [ 36 ]).…”

Section: Methodsmentioning

confidence: 99%

White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition

Garnier‐Crussard¹,

Bougacha²,

Wirth³

et al. 2020

Alz Res Therapy

View full text Add to dashboard Cite

Background White matter hyperintensities (WMH) are very frequent in older adults and associated with worse cognitive performance. Little is known about the links between WMH and vascular risk factors, cortical β-amyloid (Aβ) load, and cognition in cognitively unimpaired adults across the entire lifespan, especially in young and middle-aged adults. Methods One hundred and thirty-seven cognitively unimpaired adults from the community were enrolled (IMAP cohort). Participants underwent (i) a comprehensive neuropsychological assessment of episodic memory, processing speed, working memory, and executive functions; (ii) brain structural T1 and FLAIR MRI scans used for the automatic segmentation of total and regional (frontal, parietal, temporal, occipital, and corpus callosum) WMH; and (iii) a Florbetapir-PET scan to measure cortical Aβ. The relationships of total and regional WMH to age, vascular risk factors, cortical Aβ, and cognition were assessed within the whole sample, but also splitting the sample in two age groups (≤ or > 60 years old). Results WMH increased with age across the adult lifespan, i.e., even in young and middle-aged adults. Systolic blood pressure, diastolic blood pressure, and glycated hemoglobin were all associated with higher WMH before, but not after, adjusting for age and the other vascular risk factors. Higher frontal, temporal, and occipital WMH were associated with greater Aβ, but this association was no longer significant when adjusting for age and vascular risk factors. Higher total and frontal WMH were associated with worse performance in executive functions, with no interactive effect of the age group. In contrast, there was a significant interaction of the age group on the link between WMH and working memory, which was significant within the subgroup of young/middle-aged adults only. Adding cortical Aβ load in the models did not alter the results, and there was no interaction between WMH and Aβ on cognition. Conclusion WMH increased with age and were associated with worse executive functions across the adult lifespan and with worse working memory in young/middle-aged adults. Aβ load was weakly associated with WMH and did not change the relationship found between WMH and executive functions. This study argues for the clinical relevance of WMH across the adult lifespan, even in young and middle-aged adults with low WMH.

show abstract

“…We auto-segmented white matter hyperintensities using the LST toolbox and measured the volumes of white matter hyperintensities (Wirth et al, 2019 ). Central and cortical brain atrophy were categorized into three scores (0 = none, 1 = modest, and 2 = severe) as shown in a previous study (Sato et al, 2016 ).…”

Section: Methodsmentioning

confidence: 99%

Dysfunction of the Glymphatic System Might Be Related to Iron Deposition in the Normal Aging Brain

Zhou

Shen

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

Objective: The study aims to detect the potential relationship between iron deposition and the function of the glymphatic system in the normal aging brain.Methods: We recruited 213 healthy participants. We evaluated the function of the glymphatic system using the index for diffusivity along the perivascular space (ALPS-index), assessed iron deposition on quantitative susceptibility mapping (QSM), and analyzed their relationship.Results: The mean age of participants was 60.1 ± 7.3, and 107 (50.2%) were female. The mean ALPS-index was 1.4 ± 0.2. The QSM values of the caudate nucleus, putamen, globus pallidus, thalamus, red nucleus, substantia nigra, and dentate nucleus were all related to the ALPS-index (all P < 0.001).Conclusions: The main finding of the current study is that the regional brain iron deposition was related to the function of the glymphatic system.Advances in knowledge: We first evaluated the relationship between deposition of brain iron and the dysfunction of the glymphatic system.

show abstract

Value of fluid‐attenuated inversion recovery MRI data analyzed by the lesion segmentation toolbox in amyotrophic lateral sclerosis

Cited by 10 publications

References 32 publications

Diagnostic and Prognostic Value of Conventional Brain MRI in the Clinical Work-Up of Patients with Amyotrophic Lateral Sclerosis

Diagnostic and Prognostic Value of Conventional Brain MRI in the Clinical Work-Up of Patients with Amyotrophic Lateral Sclerosis

White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition

Dysfunction of the Glymphatic System Might Be Related to Iron Deposition in the Normal Aging Brain

Contact Info

Product

Resources

About