Value of gamma-glutamyltranspeptidase-to-platelet ratio in diagnosis of hepatic fibrosis in patients with chronic hepatitis B

Abstract

AIMTo investigate the value of the gamma-glutamyltraspeptidase (GGT)-to-platelet (PLT) ratio (GPR) in the diagnosis of hepatic fibrosis in patients with chronic hepatitis B (CHB).METHODSWe included 390 untreated CHB patients in this study. The GPR, aspartate aminotransferase (AST)-to-PLT ratio index (APRI), and fibrosis-4 (FIB-4) of all patients were analysed to determine if these parameter were correlated with age, gender, medical history, liver function [total bilirubin (TBil), alanine aminotransferase (ALT), and AST], GGT, PLT count, or hepatic fibrosis stage. The GPR, APRI, and FIB-4, as well as the combination of the GPR and APRI or the GPR and FIB-4 were assessed in different cirrhosis stages using receiver operating characteristic (ROC) curve analysis to evaluate their value in diagnosing hepatic fibrosis in CHB patients.RESULTSThe GPR, APRI, and FIB-4 were not correlated with CHB patients’ age, gender, or disease duration (P > 0.05), but all of these parameters were positively correlated with serum ALT, AST, GGT, and PLT count (P < 0.01). Additionally, the GPR, APRI, and FIB-4 were positively correlated with hepatic fibrosis (P < 0.01); the areas under the ROC curve for the GPR in F1, F2, F3, and F4 stages were 0.723, 0.741, 0.826, and 0.833, respectively, which were significantly higher than the respective values for the FIB-4 and APRI (F1: 0.581, 0.612; F2: 0.706, 0.711; F3: 0.73, 0.751; and F4: 0.799, 0.778). The respective diagnostic cut-off points for each stage were 0.402, 0.448, 0.548, and 0.833, respectively. The diagnostic sensitivity and specificity were, respectively, 88.8% and 87.5% in F1, 72.7% and 89.7% in F2, 81.3% and 98.6% in F3, and 80% and 97.4% in F4 when the GPR and APRI were connected in parallel; 86.6% and 90.2%, 78.4% and 96%, 78.6% and 97.4%, and 73.2% and 97.9%, respectively, when the GPR and APRI were connected in series; 80.2% and 89%, 65% and 89%, 70.3% and 98.5%, and 78.8% and 96.8%, respectively, when the GPR and FIB-4 were connected in parallel; and 83.6% and 87.9%, 76.8% and 96.6%, 72.7% and 98%, and 74.4% and 97.7%, respectively, when the GPR and FIB-4 were connected in series.CONCLUSIONThe GPR, as a serum diagnostic index of liver fibrosis, is more accurate, sensitive, and easy to use than the FIB-4 and APRI, and the GPR can significantly improve the sensitivity and specificity of hepatic fibrosis diagnosis in CHB when combined with the FIB-4 or APRI.

NGF (−198C > T, Ala35Val) and p75NTR (Ser205Leu) gene mutations are associated with liver function in different histopathological profiles of the patients with chronic viral hepatitis in the Brazilian Amazon

“…It is considered in the risk assessment of liver fibrosis that both AST and ALT may remain normal even in cirrhosis situations (Newsome et al, 2018). GGT, in turn, is considered a serum predictor of histopathological evolution (Hu et al, 2017). However, in the present study, the high prevalence of individuals with no liver parenchymal abnormalities is suggested in the lack of association between GGT and fibrosis.…”

Multicenter prospective study to validate a new transient elastography device for staging liver fibrosis in patients with chronic hepatitis B

“…In line with some recent reports, our studies have found that the AUROC for the GPR in F1 to F4 stages was significantly higher than those for FIB-4 index and APRI. [28][29][30] The study was mainly limited by the small proportion of samples that were F4 (6.3%). In addition, we were not able to test the influence of a high ALT level as we had excluded patients with an ALT of 5 × ULN or higher.…”

The prognostic significance of pretreatment serum γ-glutamyltranspeptidase in primary liver cancer: a meta-analysis and systematic review

“…Evidences showed that several inflammatory cytokines, including tumor necrosis factor α, interferon-α, and interferon-β, could induce GGT expression [ 45 , 46 ]. Additionally, it was also reported that serum GGT level associates with the active status, fibrosis and cirrhosis stage of chronic hepatitis [ 51 , 52 ] and functions as a biomarker of the inflamed liver microenvironment in hepatitis [ 53 ]. Therefore, it may be hypothesized that GGT reflects or participates in the tumor-associated inflammatory responses to predict the prognosis of tumor patients.…”