Value of GATA3 Immunostaining in Tumor Diagnosis

Abstract

GATA3 is a member of a group of zinc-finger transcription factors that is involved in cell development and differentiation. Recent studies have shown that, among tumors, GATA3 is commonly expressed in both urothelial tumors and breast epithelial neoplasms. With the exception of salivary gland and parathyroid tumors, GATA3 has been reported to be either absent or only rarely expressed in other epithelial tumors. Owing to its restricted expression in urothelial and breast carcinomas, GATA3 has proved to be a useful immunohistochemical marker for assisting in distinguishing these 2 groups of neoplasms from other malignancies with which they may be confused.

Can gata3 immunocytochemistry be utilized as a reliable diagnostic marker for metastatic breast carcinoma in cytological materials?<br>a comparative study with mammaglobin and gcdfp-15 expression

“…Therefore, GATA3 could be used as a panel with the mammaglobin marker for breast differentiation. Others have agreed with these results (9,19). Based on experience with cytological materials, markers with nuclear staining (such as GATA3) are superior to those with cytoplasmic staining such as mammaglobin and GCDFP-15 (1,13).…”

Telomerase reverse transcriptase promoter mutations in glandular lesions of the urinary bladder

“…With the combination of morphologic evaluation, Immunohistochemistry (IHC) profile (GATA3, CDX2, prostate markers, and Pax8), and clinical history, often, an accurate diagnosis can be rendered. However, UC with glandular components often lose classic immunohistochemical markers such as GATA3 [19]. Bladder adenocarcinomas are also typically negative for GATA3, with the exception of signet ring cell adenocarcinoma of the bladder [20].…”

GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin

“…The immunohistochemical (IHC) detection of the GATA3 gene product has become a useful diagnostic test for a number of tumors, most prominently those in the bladder and breasts [15][16][17]. Before the availability of GATA3, gross cystic disease fluid protein 15 (GCDFP-15) and mammaglobin were the 2 most commonly used IHC markers of mammary epithelial differentiation.…”