Value of glut-1 and koc markers in the differential diagnosis of reactive mesothelial hyperplasia, malignant mesothelioma and pulmonary adenocarcinoma

Üçer, Özlem; Dağlı, Adile Ferda; Kılıçarslan, Ahmet; Artaş, Gökhan

doi:10.5146/tjpath.2013.01158

Cited by 9 publications

(4 citation statements)

References 34 publications

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“…Given external stimulation and onset of endometrial cancer, the progression is accelerated, and tumor invasion and metastasis are further enhanced. 22 …”

Section: Discussionmentioning

confidence: 99%

Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues

Ma¹,

Hui²,

Lin³

et al. 2015

Pak J Med Sci

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Objective:To analyze the clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues.Methods:One hundred and eight tissue samples from the patients with endometrial cancer enrolled in our hospital from August 2011 to July 2014 were selected, including 60 normal tissue samples (normal group), 60 neoplastic tissue samples (neoplastic group) and 60 cancer tissue samples (cancer group). All the samples were subjected to immunohistochemical assay to detect the expressions of COX-2, GLUT-1 and VEGF. The clinical data were also investigated for correlation analysis.Results:The positive rates of COX-2 in normal group, neoplastic group and cancer groups were 3.3%, 21.7% and 55.0% respectively. The positive rates of GLUT-1 in normal group, neoplastic group and cancer groups were 3.3%, 25.0% and 70.0% respectively. The positive rates of VEGF in normal group, neoplastic group and cancer groups were 1.7%, 23.3% and 63.3% respectively. With increasing stage of such cancer, decreasing degree of differentiation and lymphatic metastasis, the positive expression rates of COX-2, GLUT-1 and VEGF proteins were raised significantly (P<0.05). Spearman’s correlation analysis showed that the expressions of COX-2 and GLUT-1 (r=0.207, P<0.05), COX-2 and VEGF (r=0.243, P<0.05), as well as GLUT-1 and VEGF (r=0.758, P<0.05) were positively correlated.Conclusion:COX-2, GLUT-1 and VEGF were highly prominent in endometrial cancer, especially in the patients with low degree of differentiation, late stage and metastasis. They functioned synergistically in the onset and progression of this cancer.

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“…Given external stimulation and onset of endometrial cancer, the progression is accelerated, and tumor invasion and metastasis are further enhanced. 22 …”

Section: Discussionmentioning

confidence: 99%

Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues

Ma¹,

Hui²,

Lin³

et al. 2015

Pak J Med Sci

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“… Summary of literature findings on the prevalence of IMP3 expression in human cancers: Red circles indicate the results of the current study. Findings from the literature ( 4 – 6 , 8 , 9 , 12 – 27 , 34 – 37 , 42 , 46 , 48 , 62 – 95 ) sequence of citations equals the sequence of the tumor types from top to bottom) are marked by gray circles. …”

Section: Figurementioning

confidence: 99%

“…However, as the number of studies suggesting biological and clinical relevance of IMP3 is rapidly increasing, there are also a growing number of reports revealing considerable discrepancies with respect to the frequency of expression in various types of cancer. For example, reported frequencies in IMP3 expression ranges from 0 to 83% in prostate cancer ( 13 – 16 ), from 11 to 86% in papillary thyroid cancer ( 17 – 20 ), from 11 to 65% in papillary renal cell cancer ( 9 , 12 ), from 0 to 52% in leiomyoma ( 21 , 22 ), from 21 to 71% in invasive urinary bladder tumor ( 23 , 24 ), from 50 to 100% in small cell lung cancer ( 3 , 25 ), and from 37 to 83% in malignant mesothelioma ( 26 , 27 ). Such discrepancies may be due to the use of different antibodies, staining protocols, and scoring criteria in these studies.…”

Section: Introductionmentioning

confidence: 99%

IMP3 overexpression occurs in various important cancer types and is linked to aggressive tumor features: A tissue microarray study on 8,877 human cancers and normal tissues

et al. 2017

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IMP3 is an RNA binding protein required for ribosomal RNA processing, which has been suggested to be a prognostic marker in a large variety of human types of cancer. However, available data on the prevalence of IMP3 expression are largely discrepant. To systematically investigate the epidemiology and clinical relevance of IMP3 expression in human cancers we employed a two-step tissue microarrays (TMAs) approach. First, a normal tissue TMA and a multi-tumor TMA were analyzed for immunohistochemically detectable expression of IMP3 in 76 different normal tissue types and 3889 cancer samples from 95 different tumor categories. In a second step, we searched for associations between IMP3 expression and tumor phenotype and patient prognosis in TMAs containing 697 urinary bladder cancers, 1711 colon cancers, 343 esophageal adenocarcinomas, 251 esophageal squamous cell cancers, 673 lung cancers), 275 pancreatic cancers and 230 stomach cancers. In normal tissues, unequivocal IMP3 expression was found in placenta, lymphocytes and some types of glandular epithelial cells. In cancers, at least one case with weak expression could be found in 76 out of 95 (80%) different tumor types and 64 entities (67%) had at least one tumor with strong positivity. IMP3 expression was most frequently found in testicular cancer (including 71% seminomas and 96% non-seminomas), neuroblastoma (88%), and squamous cell cancer of various origins. Significant associations were found between IMP3 and adverse tumor features in esophageal adenocarcinomas and cancers of the urinary bladder, lung, stomach, and pancreas. In summary, IMP3 was frequently expressed in many different tumor types, and was typically associated with aggressive tumor features.

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“…A major challenge is the differentiation of malignant mesothelioma from reactive mesothelial cells. The same challenge exists for differentiation from lung adenocarcinomas [11]. …”

Section: Discussionmentioning

confidence: 99%

A Cause of Bilateral Chylothorax: A Case of Mesothelioma without Pleural Involvement during Initial Diagnosis

Kurtipek

Karanis

Düzgün

et al. 2015

Case Reports in Pulmonology

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Chylothorax is characterized by fluid accumulation in the pleural cavity containing chylomicrons due to disruption of lymphatic drainage in the thoracic ductus and development of chylothorax. A 60-year-old male patient presented to our clinic with shortness of breath and displayed bilateral pleural effusion and diffuse mediastinal lymph nodes in his computed chest tomography images. There were no thickening and nodular formation on the pleural surfaces. PET-CT showed no pathological FDG uptake. Thoracentesis showed a chylous effusion. Drainage reduced during monitoring could not be stopped; therefore, surgical intervention was considered. The patient underwent right thoracotomy. There were no pathological findings in the parietal and visceral pleura during the surgery. Initially lymphoma was considered. Perioperative samples were collected from the mediastinal lymph node. The pathology analysis reported metastasis of malignant mesothelioma. Evaluation of a repeated chest computed tomography showed nodular formations on the pleural surfaces. Mediastinal lymph nodes compressed the ductus thoracicus, resulting with chylothorax. The present case, with malignant mesothelioma, bilateral chylothorax, and mediastinal lymph node without any pleural involvement during initial diagnosis, is rare and will hence contribute to the literature.

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Value of glut-1 and koc markers in the differential diagnosis of reactive mesothelial hyperplasia, malignant mesothelioma and pulmonary adenocarcinoma

Abstract: In conclusion, GLUT-1 and KOC markers do not differentiate malignant mesotheliomas from pulmonary adenocarcinomas but can be useful in differentiating reactive mesothelial hyperplasia from malignant mesothelioma and lung adenocarcinoma.

Cited by 9 publications

References 34 publications

Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues

Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues

IMP3 overexpression occurs in various important cancer types and is linked to aggressive tumor features: A tissue microarray study on 8,877 human cancers and normal tissues

A Cause of Bilateral Chylothorax: A Case of Mesothelioma without Pleural Involvement during Initial Diagnosis

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