“…7 In the absence of subclinical AF detected by prolonged ECG monitoring, potential causes of ESUS include atrial cardiomyopathy, left ventricular dysfunction or heart failure, aortic plaques, and PFO. 8 However, 1 in 7 young ESUS patients has additional chronic ischemic lesions. These lesions were associated with several vascular risk factors, lower probability of a pathogenic PFO, and lower stroke recurrence.…”