Value of Interatrial Block for the Prediction of Silent Ischemic Brain Lesions

Çinier, Göksel; Tekkeşin, Ahmet İlker; Çelik, T.; Mercan, Özlem; Tanboğa, Halil İbrahim; Günay, Muhammed Burak; Türkkan, Ceyhan; Hayıroğlu, Mert İlker; Alexander, Bryce; Alper, Ahmet Taha; Baranchuk, Adrián

doi:10.4022/jafib.2037

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…IAB was present in 59% of the patients with silent brain ischemia. Older age, uncontrolled hypertension, and higher CHA2DS2-VASc were significantly more common in patients with silent vascular disease 16 .…”

Section: Iabs and Silent Cerebrovascular Diseasementioning

confidence: 93%

Neurological complications of interatrial blocks and BayesÓ? syndrome

Farina¹,

Miranda-Arboleda²,

Lomini³

et al. 2022

RMN

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Interatrial blocks (IABs) are a variety of abnormalities in the interatrial conduction. Bayes' syndrome is a clinical entity based on the association between advanced IABs and supraventricular tachyarrhythmias, being atrial fibrillation (AF) the most frequent. Due to its negative effects on left atrial electromechanical function, both IABs and Bayes' syndrome are associated with thromboembolic phenomena, causing cardiovascular and neurological complications. In regard to neurological involvement, patients with these conditions have an increased incidence of ischemic events, cognitive impairment, and dementia. These observations triggered the question whether the use of early anticoagulation therapy (before the documentation of AF) could prevent thromboembolic events in patients with IABs diagnosis. This review aims to summarize the most recent evidence describing the association of IABs and Bayes' syndrome with neurological events. Potential early therapeutic options to prevent these undesirable clinical consequences will be also discussed.

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Section: Iabs and Silent Cerebrovascular Diseasementioning

confidence: 93%

Neurological complications of interatrial blocks and BayesÓ? syndrome

Farina¹,

Miranda-Arboleda²,

Lomini³

et al. 2022

RMN

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“…Cinier et al 28 realizaron un estudio cuyo objetivo fue evaluar la relación entre el BIA y la ocurrencia de lesiones isquémicas cerebrales silentes (SIBL) detectadas mediante resonancia cerebral. Las SIBL se definieron como lesiones presentes en la evaluación radiológica que no se correspondían con síntomas de lesión en dicha localización.…”

Section: Desarrollounclassified

Síndrome de Bayés, accidente cerebrovascular y demencia

Iomini

Martínez‐Sellés

Elosúa³

et al. 2021

Arch Peru Cardiol Cir Cardiovasc

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El síndrome de Bayés es una entidad clínica que se define como la asociación entre la presencia de bloqueo interauricular avanzado (BIA-A), y el desarrollo de taquiarritmias supraventriculares (TSV), siendo la fibrilación auricular (FA), la más frecuente. Esta asociación salió a la luz con los estudios del Prof. Antoni Bayés de Luna en los años ‘80. Estudios realizados posteriormente por otros grupos encontraron una fuerte asociación entre este síndrome y la ocurrencia de fenómenos tromboembólicos, siendo el accidente cerebrovascular (ACV) el más grave. Del mismo modo, se documentó una asociación con deterioro cognitivo y demencia. Esto generó la pregunta acerca de si la terapia de anticoagulación previa a la documentación de FA podría prevenir la ocurrencia de tromboembolismos asociados al BIA-A y de esta manera preservar el estado cognitivo. Esta pregunta permanece, aún hoy, sin respuesta definitiva. Existen estudios en diferentes estadios de su desarrollo cuyo objetivo es comparar la efectividad de la anticoagulación en pacientes con BIA-A y sin FA documentada. Los resultados de los mismos permitirán establecer la efectividad de esta opción terapéutica temprana y, de manera conclusiva, definir si, para decidir anticoagular un paciente, la FA tiene que ser previamente documentada o no.

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“…Left atrial (LA) enlargement, an easily-measurable phenomenon, is the default clinical hallmark of structural remodeling that occurs most often in response to LA pressure and volume overload. Changes in LA size, as an index of atrial remodeling, are markers of cardiovascular risk in the general population and also in patients with AF (3)(4)(5)(6)(7)(8). There is growing evidence of inflammatory and fibrotic cytokines involvement in the context of both AF occurrence and LA remodeling.…”

Section: Introductionmentioning

confidence: 99%

Macrophage Inflammatory Protein-1 Alpha, a Potential Biomarker for Predicting Left Atrial Remodeling in Patients With Atrial Fibrillation

Chen

Wang

Chuang

et al. 2021

Front. Cardiovasc. Med.

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Objectives: Left atrial (LA) remodeling itself is an independent risk factor for ischemic stroke and mortality, with or without atrial fibrillation (AF). Macrophage inflammatory protein-1 alpha (MIP-1α) has been reported to be involved in the induction of autoimmune myocarditis and dilated cardiomyopathy. Little is known about whether MIP-1α can be used to predict LA remodeling, especially in patients with AF.Methods: We prospectively enrolled 78 patients who had received a cardiac implantable electronic device due to sick sinus syndrome in order to define AF accurately. AF was diagnosed clinically before enrollment, according to 12-lead electrocardiography (ECG) and 24-h Holter test in 54 (69%) patients. The serum cytokine levels and the mRNA expression levels of peripheral blood leukocytes were checked and echocardiographic study was performed on the same day within 1 week after the patients were enrolled into the study. The 12-lead ECG and 24-h Holter test were performed on the same day of the patients' enrollment, and the device interrogation was performed every 3 months after enrollment. The enrolled patients were clinically followed up for 1 year.Results: There was no difference in baseline characteristics, cytokine levels and mRNA expression between patients with and without AF. Larger LA volume was positively correlated with higher levels of MIP-1α (r = 0.461, p ≤ 0.001) and the atrial high-rate episodes (AHREs) burden (r = 0.593, p < 0.001), and negatively correlated with higher levels of transforming growth factor (TGF)-β1 (r = −0.271, p = 0.047) and TGF-β3 (r = −0.279, p = 0.041). The higher AHREs burden and MIP-1α level could predict LA volume independently. The mRNA expression of RORC was negatively associated with the MIP-1α level.Conclusions: This study showed that higher MIP-1α was significantly associated with LA remodeling and may have the potentials to predict LA remodeling in terms of a larger LA volume, and that circadian gene derangement might affect the expression of MIP-1α.

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Value of Interatrial Block for the Prediction of Silent Ischemic Brain Lesions

Cited by 9 publications

References 25 publications

Neurological complications of interatrial blocks and BayesÓ? syndrome

Neurological complications of interatrial blocks and BayesÓ? syndrome

Síndrome de Bayés, accidente cerebrovascular y demencia

Macrophage Inflammatory Protein-1 Alpha, a Potential Biomarker for Predicting Left Atrial Remodeling in Patients With Atrial Fibrillation

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