Value of ischemia-modified albumin in the diagnosis of pulmonary embolism

Türedi, Süleyman; Gunduz, Abdülkadir; Menteşe, Ahmet; Karahan, Süleyman Caner; Yilmaz, Sennur Ekici; Eroğlu, Oğuz; Nuhoğlu, İrfan; Turan, İbrahim; Topbaş, Murat

doi:10.1016/j.ajem.2006.12.013

Cited by 117 publications

(79 citation statements)

References 14 publications

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“…These studies suggest that IMA can be an assistant marker in the exclusion of PE. The rise in IMA level was attributed to direct tissue hypoxia-induced ischemia, the formation of infarct tissue, and especially tissue hypoxia arising following massive embolism-associated hypotension (14). In another study, IMA levels in patients with mesenteric ischemia were significantly higher compared to those of the control group.…”

Section: Discussionmentioning

confidence: 84%

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The diagnostic value of ischemia-modified albumin in the diagnosis of aortic pathology

Eroğlu¹,

Turkmen²,

Menteşe³

et al. 2014

Turk J Med Sci

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This study was designed to synthesize and evaluate derivatives of scopolamine (1) as acetylcholine esterase and protease inhibitors. Scopolamine (1) was extracted from the aerial parts of Datura innoxia through bioassay guided fractionation. Five different derivatives of scopolamine (1) were synthesized, and identified through spectroscopic studies. Their acetylcholine esterase (AChE) and trypsin inhibitory potentials were determined through standard protocols and evaluated from the perspective of structure-activity relationship.The synthesized scopolamine derivatives (2-6) showed remarkable AChE inhibitory activity, except for scopoline (6). The results showed higher enzyme inhibition potential of the synthesized compounds (2-5) as compared to scopolamine (1). Maximum inhibition was exhibited by scopolamine N -oxide (89.9 ± 1.2%, IC 50 = 37.4 ± 1.1 μ M)), followed by scopolamine sulfonic acid (70.3 ± 0.8%, IC 50 = 46.9 ± 1.0 μ M) and O -methyl scopolamine (66.1 ± 1.2%, IC 50 = 94.7 ± 0.8 μ M). All derivatives showed moderate activity against trypsin; maximum activity was exhibited by 6 (54.0 ± 1.4%) with IC 50 = 621.2 ± 3.7 μ M.

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Section: Discussionmentioning

confidence: 84%

“…That study examined IMA levels in 30 subjects diagnosed with PE using spiral computerized tomographic angiography and 30 healthy volunteers. IMA levels were significantly higher in the PE group compared to the healthy group (14). In another study, D-dimer was compared with IMA.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic value of ischemia-modified albumin in the diagnosis of aortic pathology

Eroğlu¹,

Turkmen²,

Menteşe³

et al. 2014

Turk J Med Sci

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“…IMA, a Food and Drug Administration-approved serum biomarker of cardiac ischemia, appears to be an indicator of oxidative stress and may not be specific for cardiac ischemia [24].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oxidative stress balance in acute deep vein thrombosis

et al. 2015

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Objective: The purpose of this study was to show the association between oxidative stress and deep venous thrombosis (DVT) by determining total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) values in patients with DVT and to take precautionary measures to balance oxidative status. Methods: TOS, TAS and OSI levels in serum from 52 individuals with DVT and 45 without DVT were compared. Results: TOS and OSI levels were significantly higher in patients with DVT compared with the control group (p<0.0001), but no difference was observed in TAS levels (p=0.118). The patient group was divided into two subgroups, idiopathic and secondary DVT. TOS and OSI levels were significantly higher patients with both idiopathic DVT and secondary DVT compared to the control group (p<0.0001). TAS levels were significantly higher in patients with idiopathic DVT than in the control group, but no difference was observed in the patients with secondary DVT. Conclusion: Specificity and sensitivity values obtained from the receiver operating characteristic (ROC) curve show that TOS and OSI are both markers that can be used in the diagnosis of DVT. Also, determination of oxidative stress markers may guide clinicians to take necessary precautions to balance oxidative stress in the patients. Key Words: Deep vein thrombosis, oxidative stress, total oxidant status, total antioxidant status Conflict of Interest: The authors have no conflict of interest. ÖZETAmaç: Bu çalışmanın amacı akut derin ven trombozlu (DVT) hastalarda toplam oksidan durum (TOS), toplam antioksidan durum (TAS) ve oksidatif stres indeksi (OSI) düzeylerini ölçerek oksidatif stres ve DVT arasındaki ilişkiyi ortaya koymak ve klinisyenlerin bu hastalarda oksidatif stresi dengelemek üzere koruyucu önlemler almasına yardımcı olmaktır. Metod: Bu çalışmada 52 DVT'li ve 45 DVT olmayan bireylerden alınan serum örneklerinde TOS, TAS ve OSI seviyeleri belirlenerek karşılaştırıldı. Bulgular: TOS ve OSI seviyeleri DVT hastalarında kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı yüksek bulunurken (p<0.0001) TAS seviyelerinde fark görülmedi, p=0.118. Hasta grubu idiopatik ve sekonder DVT olarak iki gruba ayrıldı. TOS ve OSI seviyeleri hem idiyopatik DVT hem de sekonder DVT hastalarında kontrol grubu ile karşılaştırıldı-ğında istatistiksel olarak anlamlı yüksek bulundu (p<0.0001). İdiyopatik DVT hastalarında TAS seviyeleri kontrol grubundan anlamlı yüksek iken sekonder DVT hastalarında fark gözlenmedi. Sonuç: Sonuç olarak ROC eğrisine göre elde edilen spesifite ve sensitivite değerleri TOS ve OSI parametrelerinin DVT'nin tanısında kullanılabilecek birer belirteç olabileceğini göster-mektedir. Aynı zamanda oksidatif stres belirteçlerinin belirlenmesi hastalarda oksidatif stresin düzeltilmesi için klinisyenlere gerekli önlemleri alabilmeleri için yol gösterici olabilir. Anahtar Kelimeler: Derin ven trombozu, oksidatif stres, toplam antioksidan durum, toplam oksidan durum Çıkar Çatışması: Yazarların çıkar çatışması yoktur.

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“…An incre a sing num ber of stu di es ha ve shown that IMA le vels ri se in va ri o us acu te isc he mic con di ti ons, such as ce reb ral, myo car di al, pul mo nary and mesen te ric in farc ti on, so that IMA can be used as a diag nos tic mar ker. 4 …”

Section: Ischemia-modified Albumin As An Early Diagnostic Marker For mentioning

confidence: 99%

“…de ter mi ned ele va ted IMA le vels in pul mo nary em bo lism. 18,19 IMA is al so ele va ted in ot her isc he mic di se a ses such as limb isc he mi a and isc he mic ce reb ro vas cu lar ac ci dents. [20][21][22][23] The num ber of stu di es in ves ti ga ting the cor rela ti on bet we en IMA le vels and kid ney da ma ge or re nal in suf fi ci ency is li mi ted.…”

Section: His To Pat Ho Lo Gi Cal Exa MI Na Ti Onmentioning

confidence: 99%

Ischemia-Modified Albumin as an Early Diagnostic Marker for Acute Renal Ischemia and Infarction

Karahan¹,

Turkmen²,

Menteşe³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Acu te re nal in farc ti on is a con di ti on sel dom en co un te red in emer gency de part ments and it is ge ne rally di ag no sed by chan ce when con si de ring ot her di ag no ses. This study in ves ti ga tes whet her or not se rum isc he mi a-mo di fi ed al bu min (IMA) le vels ri se in rats sub jec ted to re nal isc he mi a and in farc ti on produced by clam ping of the re nal ar tery. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : In this ran do mi zed, con trol led and non-blin ded tri al, 24 ma tu re ma le Wis tar rats we re di vi ded in to fo ur, as two con trol gro ups (Gro ups I and II I) and two in ter ven ti on gro ups (Gro ups II and IV). In the con trol gro ups, blo od was samp led in Gro up I at the 30th mi nu te and in Gro up III at the sixth ho ur, fol lo wing a simp le la pa ro tomy. In in ter ven ti on gro ups II and IV, the re nal ar tery was li ga ted le a ding to isc he mi a, and blo od samp les we re ta ken at the 30th minu te and sixth ho ur, res pec ti vely. R Re e s su ul lt ts s: : No dif fe ren ce was de ter mi ned in terms of IMA le vels in blo od samp les ta ken from the con trol and isc he mi a gro ups at the 30th mi nu te (p= 0.12), altho ugh plas ma IMA le vels in the isc he mi a gro ups we re sig ni fi cantly hig her com pa red to tho se of the con trol gro ups in the 6th ho ur blo od samp les (p= 0.01). In ad di ti on, in the isc he mi a group, sixth ho ur blo od samp le le vels we re hig her than the 30th mi nu te samp le levels (p= 0.011). C Co on nc c l lu u s si i o on n: : Our pre li mi nary fin dings sug gest that the re is no sig ni fi cant ri se in IMA le vels in the hype ra cu te pe ri od (first 30 mi nu tes) of acu te re nal isc he mi a, ho we ver IMA le vels me a su red at the sixth ho ur may rep re sent a sig ni fi cant di ag nos tic pa ra me ter altough furt her stu di es are neces sary.K Ke ey y W Wo or rd ds s: : Isc he mi a; in farc ti on; se rum al bu min Ö ÖZ ZE ET T A Am ma aç ç: : Akut re nal infarktüs acil ser vis ler de na dir rast la nan bir du rum dur ve ge nel lik le diğer ta nı lar üze rin de dü şü nü lür ken şans ese ri ta nı ko yu lur. Bu ça lış ma re nal ar te rin klemp lenme si yo luy la re nal is ke mi ve infarktüse ma ruz bı ra kıl mış sı çan lar da se rum da ki is ke miy le de ğiş miş al bu min (İDA) dü zey le ri nin yük se lip yük sel me di ği ni araş tır mak ta dır. G Ge e r re eç ç v ve e Y Yö ön n --t te em m l le er r: : Bu ran do mi ze, kon trol lü, kör ol ma yan ça lış ma da 24 er gin er kek Wis tar sı ça nı iki kontrol (Grup I ve II I) ve iki gi ri şim (Grup II ve IV) gru bu ol mak üze re dört gru ba ay rıl dı. Kon trol grup la rın dan Grup I' de ba sit la pa ra to mi yi ta ki ben 30. da ki ka da, Grup II I' de ise altıncı sa at te kan ör nek le ri alın dı. Gi ri şim grup la rı olan II ve IV' te re nal ar ter is ke mi ye yol aça cak şekil de bağ landı ve sı ra sıy la 30. da ki ka ve altıncı sa at ler de kan ör nek le ri alın dı. B Bu ul l g gu u l la ar r: : A...

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Value of ischemia-modified albumin in the diagnosis of pulmonary embolism

Cited by 117 publications

References 14 publications

The diagnostic value of ischemia-modified albumin in the diagnosis of aortic pathology

The diagnostic value of ischemia-modified albumin in the diagnosis of aortic pathology

Evaluation of oxidative stress balance in acute deep vein thrombosis

Ischemia-Modified Albumin as an Early Diagnostic Marker for Acute Renal Ischemia and Infarction

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